IDEAS home Printed from https://ideas.repec.org/a/eee/respol/v54y2025i2s0048733324002129.html

Medical research and health care finance: Evidence from Academic Medical Centers

Author

Listed:
  • Azoulay, Pierre
  • Heggeness, Misty
  • Kao, Jennifer

Abstract

Academic Medical Centers (AMCs) — comprising medical schools, teaching hospitals, and research laboratories — play an important role in US biomedical innovation. The Balanced Budget Act of 1997 changed reimbursements for Medicare inpatient claims and subsidies for medical residents. We compare AMCs’ relative exposure to the reform, how these differences affect their researchers’ ability to attract NIH grant funding, and the quantity, impact, and content of their publications. We find that in response to the reform, research activity increased by approximately 6%. Changes in research composition suggest that hospitals responded to Medicare funding cuts by encouraging incumbent investigators to increase their research activities and by redirecting hiring efforts towards individuals attracted to AMCs (e.g., translational researchers). We find little effect on clinical outcomes.

Suggested Citation

  • Azoulay, Pierre & Heggeness, Misty & Kao, Jennifer, 2025. "Medical research and health care finance: Evidence from Academic Medical Centers," Research Policy, Elsevier, vol. 54(2).
  • Handle: RePEc:eee:respol:v:54:y:2025:i:2:s0048733324002129
    DOI: 10.1016/j.respol.2024.105163
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0048733324002129
    Download Restriction: Full text for ScienceDirect subscribers only

    File URL: https://libkey.io/10.1016/j.respol.2024.105163?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to

    for a different version of it.

    References listed on IDEAS

    as
    1. Ina Ganguli, 2017. "Saving Soviet Science: The Impact of Grants When Government R&D Funding Disappears," American Economic Journal: Applied Economics, American Economic Association, vol. 9(2), pages 165-201, April.
    2. Daron Acemoglu & Amy Finkelstein, 2008. "Input and Technology Choices in Regulated Industries: Evidence from the Health Care Sector," Journal of Political Economy, University of Chicago Press, vol. 116(5), pages 837-880, October.
    3. Hans K. Hvide & Benjamin F. Jones, 2018. "University Innovation and the Professor's Privilege," American Economic Review, American Economic Association, vol. 108(7), pages 1860-1898, July.
    4. Tania Babina & Alex Xi He & Sabrina T Howell & Elisabeth Ruth Perlman & Joseph Staudt, 2023. "Cutting the Innovation Engine: How Federal Funding Shocks Affect University Patenting, Entrepreneurship, and Publications," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 138(2), pages 895-954.
    5. Richard Freeman & John Van Reenen, 2009. "What If Congress Doubled R&D Spending on the Physical Sciences?," Innovation Policy and the Economy, University of Chicago Press, vol. 9(1), pages 1-38.
    6. Robert M. Solow, 1956. "A Contribution to the Theory of Economic Growth," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 70(1), pages 65-94.
    7. Henderson, Rebecca., 1994. "The evolution of integrative capability : innovation in cardiovascular drug discovery," Working papers 3711-94., Massachusetts Institute of Technology (MIT), Sloan School of Management.
    8. Bronwyn H. Hall & Adam Jaffe & Manuel Trajtenberg, 2005. "Market Value and Patent Citations," RAND Journal of Economics, The RAND Corporation, vol. 36(1), pages 16-38, Spring.
    9. Murray, Fiona, 2002. "Innovation as co-evolution of scientific and technological networks: exploring tissue engineering," Research Policy, Elsevier, vol. 31(8-9), pages 1389-1403, December.
    10. Sharon Belenzon & Mark Schankerman, 2013. "Spreading the Word: Geography, Policy, and Knowledge Spillovers," The Review of Economics and Statistics, MIT Press, vol. 95(3), pages 884-903, July.
    11. Thomas G. McGuire & Mark V. Pauly, 1991. "Physician Response to Fee Changes with Multiple Payers," Papers 0015, Boston University - Industry Studies Programme.
    12. Ali, Ayfer & Gittelman, Michelle, 2016. "Research paradigms and useful inventions in medicine: Patents and licensing by teams of clinical and basic scientists in Academic Medical Centers," Research Policy, Elsevier, vol. 45(8), pages 1499-1511.
    13. Tabakovic, Haris & Wollmann, Thomas G., 2019. "The impact of money on science: Evidence from unexpected NCAA football outcomes," Journal of Public Economics, Elsevier, vol. 178(C).
    14. Jaffe, Adam B, 1989. "Real Effects of Academic Research," American Economic Review, American Economic Association, vol. 79(5), pages 957-970, December.
    15. Blume-Kohout, Margaret E. & Sood, Neeraj, 2013. "Market size and innovation: Effects of Medicare Part D on pharmaceutical research and development," Journal of Public Economics, Elsevier, vol. 97(C), pages 327-336.
    16. Russell J. Funk & Jason Owen-Smith, 2017. "A Dynamic Network Measure of Technological Change," Management Science, INFORMS, vol. 63(3), pages 791-817, March.
    17. Jeffrey L. Furman & Fiona Murray & Scott Stern, 2012. "Growing Stem Cells: The Impact of Federal Funding Policy on the U.S. Scientific Frontier," Journal of Policy Analysis and Management, John Wiley & Sons, Ltd., vol. 31(3), pages 661-705, June.
    18. Jaffe, Adam B & Lerner, Josh, 2001. "Reinventing Public R&D: Patent Policy and the Commercialization of National Laboratory Technologies," RAND Journal of Economics, The RAND Corporation, vol. 32(1), pages 167-198, Spring.
    19. Vivian Wu, 2010. "Hospital cost shifting revisited: new evidence from the balanced budget act of 1997," International Journal of Health Economics and Management, Springer, vol. 10(1), pages 61-83, March.
    20. Hall, Bronwyn H. & Lerner, Josh, 2010. "The Financing of R&D and Innovation," Handbook of the Economics of Innovation, in: Bronwyn H. Hall & Nathan Rosenberg (ed.), Handbook of the Economics of Innovation, edition 1, volume 1, chapter 0, pages 609-639, Elsevier.
    21. Shen, Yu-Chu, 2003. "The effect of financial pressure on the quality of care in hospitals," Journal of Health Economics, Elsevier, vol. 22(2), pages 243-269, March.
    22. Matt Marx & Aaron Fuegi, 2020. "Reliance on science: Worldwide front‐page patent citations to scientific articles," Strategic Management Journal, Wiley Blackwell, vol. 41(9), pages 1572-1594, September.
    23. Wei Yang Tham & Joseph Staudt & Elisabeth Ruth Perlman & Stephanie D. Cheng, 2024. "Scientific Talent Leaks Out of Funding Gaps," Papers 2402.07235, arXiv.org.
    24. Rosenberg, Nathan, 1963. "Technological Change in the Machine Tool Industry, 1840–1910," The Journal of Economic History, Cambridge University Press, vol. 23(4), pages 414-443, December.
    25. Catherine Bobtcheff & Jérôme Bolte & Thomas Mariotti, 2017. "Researcher’s Dilemma," The Review of Economic Studies, Review of Economic Studies Ltd, vol. 84(3), pages 969-1014.
    26. Sabrina T. Howell, 2017. "Financing Innovation: Evidence from R&D Grants," American Economic Review, American Economic Association, vol. 107(4), pages 1136-1164, April.
    27. Jeffrey L. Furman & Megan MacGarvie, 2007. "Academic Science and the Birth of Industrial Research Laboratories in the U.S. Pharmaceutical Industry," NBER Chapters, in: Academic Science and Entrepreneurship: Dual Engines of Growth, National Bureau of Economic Research, Inc.
    28. Partha, Dasgupta & David, Paul A., 1994. "Toward a new economics of science," Research Policy, Elsevier, vol. 23(5), pages 487-521, September.
    29. Bronwyn H. Hall, 2010. "The Financing of Innovative Firms," Review of Economics and Institutions, Università di Perugia, vol. 1(1).
    30. Josh Lerner, 2010. "The Litigation of Financial Innovations," Journal of Law and Economics, University of Chicago Press, vol. 53(4), pages 807-831.
    31. Richard C. Lindrooth & Gloria J. Bazzoli & Jan Clement, 2007. "The Effect of Reimbursement on the Intensity of Hospital Services," Southern Economic Journal, John Wiley & Sons, vol. 73(3), pages 575-587, January.
    32. Kaestner, Robert & Guardado, Jose, 2008. "Medicare reimbursement, nurse staffing, and patient outcomes," Journal of Health Economics, Elsevier, vol. 27(2), pages 339-361, March.
    33. Jacob, Brian A. & Lefgren, Lars, 2011. "The impact of research grant funding on scientific productivity," Journal of Public Economics, Elsevier, vol. 95(9), pages 1168-1177.
    34. Jeffrey R. Brown & Stephen G. Dimmock & Jun-Koo Kang & Scott J. Weisbenner, 2014. "How University Endowments Respond to Financial Market Shocks: Evidence and Implications," American Economic Review, American Economic Association, vol. 104(3), pages 931-962, March.
    35. Bronwyn H. Hall, 2009. "Business And Financial Method Patents, Innovation, And Policy," Scottish Journal of Political Economy, Scottish Economic Society, vol. 56(4), pages 443-473, September.
    36. Pierre Azoulay & Joshua S Graff Zivin & Danielle Li & Bhaven N Sampat, 2019. "Public R&D Investments and Private-sector Patenting: Evidence from NIH Funding Rules," The Review of Economic Studies, Review of Economic Studies Ltd, vol. 86(1), pages 117-152.
    37. James D. Adams & Eric P. Chiang & Jeffrey L. Jensen, 2003. "The Influence of Federal Laboratory R&D on Industrial Research," The Review of Economics and Statistics, MIT Press, vol. 85(4), pages 1003-1020, November.
    38. Valentina Tartari & Scott Stern, 2021. "More than an Ivory Tower: The Impact of Research Institutions on the Quantity and Quality of Entrepreneurship," NBER Working Papers 28846, National Bureau of Economic Research, Inc.
    39. Nathan Rosenberg, 2009. "Some Critical Episodes in the Progress of Medical Innovation: An Anglo-American Perspective," World Scientific Book Chapters, in: Nathan Rosenberg (ed.), Studies On Science And The Innovation Process Selected Works of Nathan Rosenberg, chapter 14, pages 275-301, World Scientific Publishing Co. Pte. Ltd..
    40. Mark Duggan & Fiona Scott Morton, 2010. "The Effect of Medicare Part D on Pharmaceutical Prices and Utilization," American Economic Review, American Economic Association, vol. 100(1), pages 590-607, March.
    41. Declan Butler, 2008. "Translational research: Crossing the valley of death," Nature, Nature, vol. 453(7197), pages 840-842, June.
    42. Pierre Azoulay & Joshua S. Graff Zivin & Gustavo Manso, 2011. "Incentives and creativity: evidence from the academic life sciences," RAND Journal of Economics, RAND Corporation, vol. 42(3), pages 527-554, September.
    43. Keeler, Emmett B. & Carter, Grace M. & Trude, Sally, 1988. "Insurance aspects of DRG outlier payments," Journal of Health Economics, Elsevier, vol. 7(3), pages 193-214, September.
    44. Josh Lerner, 2010. "Innovation, Entrepreneurship and Financial Market Cycles," OECD Science, Technology and Industry Working Papers 2010/3, OECD Publishing.
    45. Saul Lach & Mark Schankerman, 2008. "Incentives and invention in universities," RAND Journal of Economics, RAND Corporation, vol. 39(2), pages 403-433, June.
    46. Nathan Rosenberg, 2009. "Critical Episodes in the Progress of Medical Innovation," Chapters, in: Dominique Foray (ed.), The New Economics of Technology Policy, chapter 7, Edward Elgar Publishing.
    47. Brooks, Harvey, 1994. "The relationship between science and technology," Research Policy, Elsevier, vol. 23(5), pages 477-486, September.
    48. Balconi, Margherita & Brusoni, Stefano & Orsenigo, Luigi, 2010. "In defence of the linear model: An essay," Research Policy, Elsevier, vol. 39(1), pages 1-13, February.
    49. Marc F. Bellemare & Casey J. Wichman, 2020. "Elasticities and the Inverse Hyperbolic Sine Transformation," Oxford Bulletin of Economics and Statistics, Department of Economics, University of Oxford, vol. 82(1), pages 50-61, February.
    50. David M. Cutler, 1998. "Cost Shifting or Cost Cutting? The Incidence of Reductions in Medicare Payments," NBER Chapters, in: Tax Policy and the Economy, Volume 12, pages 1-28, National Bureau of Economic Research, Inc.
    51. Mark Duggan & Fiona M. Scott Morton, 2006. "The Distortionary Effects of Government Procurement: Evidence from Medicaid Prescription Drug Purchasing," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 121(1), pages 1-30.
    52. Yip, Winnie C., 1998. "Physician response to Medicare fee reductions: changes in the volume of coronary artery bypass graft (CABG) surgeries in the Medicare and private sectors," Journal of Health Economics, Elsevier, vol. 17(6), pages 675-699, December.
    53. Richard C. Lindrooth & Gloria J. Bazzoli & Jan Clement, 2007. "The Effect of Reimbursement on the Intensity of Hospital Services," Southern Economic Journal, Southern Economic Association, vol. 73(3), pages 575-587, January.
    54. Amitabh Chandra & Amy Finkelstein & Adam Sacarny & Chad Syverson, 2016. "Health Care Exceptionalism? Performance and Allocation in the US Health Care Sector," American Economic Review, American Economic Association, vol. 106(8), pages 2110-2144, August.
    55. Rosenberg,Nathan, 1994. "Exploring the Black Box," Cambridge Books, Cambridge University Press, number 9780521459556, January.
    56. Liu, Weishu & Hu, Guangyuan & Tang, Li, 2018. "Missing author address information in Web of Science—An explorative study," Journal of Informetrics, Elsevier, vol. 12(3), pages 985-997.
    57. Nicholson, Sean & Song, David, 2001. "The incentive effects of the Medicare indirect medical education policy," Journal of Health Economics, Elsevier, vol. 20(6), pages 909-933, November.
    58. Alice Chen & Dana Goldman, 2016. "Health Care Spending: Historical Trends and New Directions," Annual Review of Economics, Annual Reviews, vol. 8(1), pages 291-319, October.
    59. David Dranove & Craig Garthwaite & Christopher Ody, 2017. "How do nonprofits respond to negative wealth shocks? The impact of the 2008 stock market collapse on hospitals," RAND Journal of Economics, RAND Corporation, vol. 48(2), pages 485-525, May.
    60. He, Daifeng & Mellor, Jennifer M., 2012. "Hospital volume responses to Medicare's Outpatient Prospective Payment System: Evidence from Florida," Journal of Health Economics, Elsevier, vol. 31(5), pages 730-743.
    61. David, Guy & Lindrooth, Richard C. & Helmchen, Lorens A. & Burns, Lawton R., 2014. "Do hospitals cross-subsidize?," Journal of Health Economics, Elsevier, vol. 37(C), pages 198-218.
    62. Pierre Azoulay & Joshua S. Graff Zivin & Gustavo Manso, 2013. "National Institutes of Health Peer Review: Challenges and Avenues for Reform," Innovation Policy and the Economy, University of Chicago Press, vol. 13(1), pages 1-22.
    63. McGuire, Thomas G. & Pauly, Mark V., 1991. "Physician response to fee changes with multiple payers," Journal of Health Economics, Elsevier, vol. 10(4), pages 385-410.
    64. Felix Poege & Dietmar Harhoff & Fabian Gaessler & Stefano Baruffaldi, 2019. "Science Quality and the Value of Inventions," Papers 1903.05020, arXiv.org, revised Apr 2019.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yi, Guanting, 2025. "Health insurance expansion and academic production: The case of Medicare Part D legislation," Social Science & Medicine, Elsevier, vol. 367(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Anckaert, Paul-Emmanuel, 2025. "When the drugs (don’t) work: The role of science in product commercialization," Research Policy, Elsevier, vol. 54(5).
    2. Heller, David, 2024. "Financial market integration and the effects of financing constraints on innovation," Research Policy, Elsevier, vol. 53(4).
    3. Hu, Yefei & Liu, Dayong, 2022. "Government as a non-financial participant in innovation: How standardization led by government promotes regional innovation performance in China," Technovation, Elsevier, vol. 114(C).
    4. Deng, Yumiao & Ding, Yongling & Li, Chen & Ma, Sichao, 2025. "Shareholding by industry peers, firm size, and innovation quality," Finance Research Letters, Elsevier, vol. 80(C).
    5. Li, Meiling & Wang, Yang & Du, Haifeng & Bai, Aruhan, 2024. "Motivating innovation: The impact of prestigious talent funding on junior scientists," Research Policy, Elsevier, vol. 53(9).
    6. Choi, Jin-Uk & Lee, Chang-Yang, 2022. "The differential effects of basic research on firm R&D productivity: The conditioning role of technological diversification," Technovation, Elsevier, vol. 118(C).
    7. Jeffrey Clemens & Joshua D. Gottlieb, 2017. "In the Shadow of a Giant: Medicare’s Influence on Private Physician Payments," Journal of Political Economy, University of Chicago Press, vol. 125(1), pages 1-39.
    8. René Belderbos & Nazareno Braito & Jian Wang, 2024. "Heterogeneous university research and firm R&D location decisions: research orientation, academic quality, and investment type," The Journal of Technology Transfer, Springer, vol. 49(5), pages 1959-1989, October.
    9. Tania Babina & Alex Xi He & Sabrina T. Howell & Elisabeth Ruth Perlman & Joseph Staudt, 2020. "The Color of Money: Federal vs. Industry Funding of University Research," NBER Working Papers 28160, National Bureau of Economic Research, Inc.
    10. Nemlioglu, Ilayda & Mallick, Sushanta K., 2020. "Do innovation-intensive firms mitigate their valuation uncertainty during bad times?," Journal of Economic Behavior & Organization, Elsevier, vol. 177(C), pages 913-940.
    11. Lu Liu & Benjamin F. Jones & Brian Uzzi & Dashun Wang, 2023. "Data, measurement and empirical methods in the science of science," Nature Human Behaviour, Nature, vol. 7(7), pages 1046-1058, July.
    12. Shigeoka, Hitoshi & Fushimi, Kiyohide, 2014. "Supplier-induced demand for newborn treatment: Evidence from Japan," Journal of Health Economics, Elsevier, vol. 35(C), pages 162-178.
    13. Santos, Anabela M. & Cincera, Michele & Cerulli, Giovanni, 2024. "Sources of financing: Which ones are more effective in innovation–growth linkage?," Economic Systems, Elsevier, vol. 48(2).
    14. Liu, Yu-Chen & Li, Yiting, 2024. "Corporate finance, collateralized borrowing, and monetary policy," European Economic Review, Elsevier, vol. 170(C).
    15. Fehder, Daniel C. & Hausman, Naomi & Hochberg, Yael V., 2025. "Innovation and capital," Journal of Financial Economics, Elsevier, vol. 169(C).
    16. Zhang, Ping & Wang, Yiru & Gao, Jieying, 2023. "Going public and innovation: Evidence from the ChiNext stock market," Economic Analysis and Policy, Elsevier, vol. 80(C), pages 586-613.
    17. Goldman, Jim & Peress, Joel, 2023. "Firm R&D and financial analysis: How do they interact?," Journal of Financial Intermediation, Elsevier, vol. 53(C).
    18. Fan, Weina & Anser, Muhammad Khalid & Nasir, Muhammad Hamid & Nazar, Raima, 2023. "Uncertainty in firm innovation scheme and impact of green fiscal policy; Economic recovery of Chinese firms in the post-Covid-19 era," Economic Analysis and Policy, Elsevier, vol. 78(C), pages 1424-1439.
    19. Bravo-Ortega, Claudio & Egana-delSol, Pablo & Winkler-Sotomayor, Nicole, 2023. "Does the lack of resources matter in a dual economy: Decoding MSMEs productivity and growth," Economic Analysis and Policy, Elsevier, vol. 80(C), pages 716-739.
    20. Perlin, Marcelo & Borenstein, Denis & Imasato, Takeyoshi & Reichert, Marcos, 2024. "The determinants and impact of research grants: The case of Brazilian productivity scholarships," Journal of Informetrics, Elsevier, vol. 18(4).

    More about this item

    Keywords

    ;
    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:respol:v:54:y:2025:i:2:s0048733324002129. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/locate/respol .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.