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More than an Ivory Tower: The Impact of Research Institutions on the Quantity and Quality of Entrepreneurship

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  • Valentina Tartari
  • Scott Stern

Abstract

This paper provides systematic empirical evidence for the distinctive role of universities on local entrepreneurial ecosystems. Assessing the impact of research institutions on entrepreneurship is challenging, given that these institutions are often located in economic and innovation environments conducive to growth-oriented entrepreneurial activity, are themselves a source of local demand, and produce knowledge, which might serve as the foundation for new ventures. To overcome this inference challenge, we first combine comprehensive business registration records with a predictive analytics approach to measure both the quantity and quality-adjusted quantity of entrepreneurship at the zip-code level on an annual basis. We then link each location to the presence or absence of research-oriented universities or national laboratories. Finally, we exploit significant changes over time in Federal commitments to both universities and national laboratories. Our key finding is that changes in Federal research commitments to universities are uniquely linked to positively correlated changes in the quality-adjusted quantity of entrepreneurship. In contrast, increases in non-research funding to universities and funding to national laboratories is associated with either a neutral or negative impact on the quality-adjusted quantity of entrepreneurship. Research funding to universities seems to play a unique role in promoting the acceleration of local entrepreneurial ecosystems.

Suggested Citation

  • Valentina Tartari & Scott Stern, 2021. "More than an Ivory Tower: The Impact of Research Institutions on the Quantity and Quality of Entrepreneurship," NBER Working Papers 28846, National Bureau of Economic Research, Inc.
  • Handle: RePEc:nbr:nberwo:28846
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    2. Mercedes Gumbau-Albert, 2024. "Understanding the Impact of Intangible Capital on Entrepreneurship at the Regional Level," Journal of the Knowledge Economy, Springer;Portland International Center for Management of Engineering and Technology (PICMET), vol. 15(3), pages 11063-11089, September.
    3. Adam B. Jaffe & Laura B. Shupp & Valentina Tartari, 2026. "Real Effects of Academic Research Revisited," NBER Chapters, in: The Economics of Science: Taking Stock and Looking Ahead, National Bureau of Economic Research, Inc.
    4. Jorge Guzman & Fiona Murray & Scott Stern & Heidi Williams, 2024. "Accelerating Innovation Ecosystems: The Promise and Challenges of Regional Innovation Engines," Entrepreneurship and Innovation Policy and the Economy, University of Chicago Press, vol. 3(1), pages 9-75.
    5. Amornsiripanitch, Natee & Gompers, Paul A. & Hu, George & Vasudevan, Kaushik, 2023. "Getting schooled: Universities and VC-backed immigrant entrepreneurs," Research Policy, Elsevier, vol. 52(7).
    6. Azoulay, Pierre & Heggeness, Misty & Kao, Jennifer, 2025. "Medical research and health care finance: Evidence from Academic Medical Centers," Research Policy, Elsevier, vol. 54(2).
    7. Sabrina T. Howell, 2024. "Government Intervention in Innovation," Annual Review of Financial Economics, Annual Reviews, vol. 16(1), pages 367-390, November.
    8. Barbara Biasi & Song Ma, 2022. "The Education-Innovation Gap," CESifo Working Paper Series 9653, CESifo.
    9. Susan Helper & Resem Makan & Daniel Shoag, 2026. "Local Returns to Federal Innovation Investment: Evidence from the National Laboratories," NBER Chapters, in: Entrepreneurship and Innovation Policy and the Economy, volume 6, National Bureau of Economic Research, Inc.
    10. Nicolas Bunde & Nina Czernich & Oliver Falck & Gabriel J. Felbermayr, 2022. "What works? Regionale Auswirkungen von Hochschulgründungen und der Fall der neuen TU Oberösterreich," ifo Forschungsberichte, ifo Institute - Leibniz Institute for Economic Research at the University of Munich, number 134, February.
    11. Fan, Jianyong & Tang, Wei & Zhang, Feng, 2026. "Persistent effects of universities on local industrial growth: Evidence from China's policy-induced college relocation in the 1950s," Journal of Development Economics, Elsevier, vol. 179(C).

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    More about this item

    JEL classification:

    • L26 - Industrial Organization - - Firm Objectives, Organization, and Behavior - - - Entrepreneurship
    • O3 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights
    • R12 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General Regional Economics - - - Size and Spatial Distributions of Regional Economic Activity; Interregional Trade (economic geography)

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