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Accelerating Innovation Ecosystems: The Promise and Challenges of Regional Innovation Engines

Author

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  • Jorge Guzman
  • Fiona Murray
  • Scott Stern
  • Heidi Williams

Abstract

Motivated by the recent establishment of major US federal programs seeking to harness the potential of regional innovation ecosystems, we assess the promise and challenges of place-based innovation policy interventions. Relative to traditional research grants, place-based innovation policy interventions are not directed toward a specific research project but rather aim to reshape interactions among researchers and other stakeholders within a given geographic location. The most recent such policy—the National Science Foundation “Engines” program—is designed to enhance the productivity and impact of the investments made within a given regional innovation ecosystem. The impact of such an intervention depends on whether, in its implementation, it induces change in the behavior of individuals and the ways in which knowledge is distributed and translated within that ecosystem. Although this logic is straightforward, from it follows an important insight: innovation ecosystem interventions—engines—are more likely to succeed when they account for the current state of a given regional ecosystem (in terms of latent capacities, current bottlenecks, and economic and institutional constraints) and when they involve extended commitments by multiple stakeholders within that ecosystem. Beyond outlining the key dependencies for place-based innovation policy interventions, we also discuss opportunities for real-time assessment and course correction of such interventions.

Suggested Citation

  • Jorge Guzman & Fiona Murray & Scott Stern & Heidi Williams, 2024. "Accelerating Innovation Ecosystems: The Promise and Challenges of Regional Innovation Engines," Entrepreneurship and Innovation Policy and the Economy, University of Chicago Press, vol. 3(1), pages 9-75.
  • Handle: RePEc:ucp:eipoec:doi:10.1086/727744
    DOI: 10.1086/727744
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    Cited by:

    1. Lin, Zeyu & Dou, Hongtao & Lin, Shanlang, 2025. "Community-powered AI: Enhancing regional development through dataset diversity and ethical governance," Technovation, Elsevier, vol. 147(C).
    2. Moh Hosseinioun & Frank Neffke & Letian Zhang & Hyejin Youn, 2025. "Skill dependencies uncover nested human capital," Nature Human Behaviour, Nature, vol. 9(4), pages 673-687, April.
    3. Miao, Ruiqing & Ulucak, Recep & Zilberman, David, 2023. "The Political Economy of Agricultural Innovation: A Review," 2023 Annual Meeting, July 23-25, Washington D.C. 337401, Agricultural and Applied Economics Association.
    4. Fitjar, Rune Dahl, 2025. "Does public R&D funding reinforce regional disparities? Exploring the changing geography of public and business R&D expenditure in Europe," Research Policy, Elsevier, vol. 54(9).
    5. Pikkarainen, Minna & Hurmelinna-Laukkanen, Pia & Iivari, Marika & Jansson, Miia & Hong-Gu, He, 2025. "Overseas innovation ecosystem collaboration in the healthcare sector," Technovation, Elsevier, vol. 147(C).
    6. Eugenie Dugoua & Jacob Moscona, 2025. "The Economics of Climate Innovation: Technology, Climate Policy, and the Clean Energy Transition," CESifo Working Paper Series 12267, CESifo.
    7. Yang, Chao & Luo, Haoxiang & Yang, Siyi & Li, Longquan & Liu, Qi, 2025. "Digital platforms and smart city synergies: Unlocking cross-sector innovation and governance in urban transformation," Technovation, Elsevier, vol. 147(C).
    8. Eugenie Dugoua & Jacob Moscona, 2025. "The Economics of climate innovation: technology, climate policy, and the clean energy transition," CEP Discussion Papers dp2135, Centre for Economic Performance, LSE.

    More about this item

    JEL classification:

    • L26 - Industrial Organization - - Firm Objectives, Organization, and Behavior - - - Entrepreneurship
    • O00 - Economic Development, Innovation, Technological Change, and Growth - - General - - - General
    • O30 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - General
    • R19 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General Regional Economics - - - Other
    • R58 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - Regional Government Analysis - - - Regional Development Planning and Policy

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