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Application-Specific R& D Capabilities and the Advantage of Incumbents: Evidence from the Anticancer Drug Market

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  • M. Lourdes Sosa

    () (Strategic and International Management Group, London Business School, London NW1 4SA, United Kingdom)

Abstract

This paper examines the proposition that during competence-destroying technological changes, incumbents are incompetent in researching in house a radically new technology. They only retain market leadership if their undestroyed, proprietary complementary assets compensate for their research incompetence. In contrast to prior research, I propose that there is not one but two sets of capabilities necessary to execute research and development (R& D), sets that differ in their market specificity: a technology-specific set (i.e., technological platforms that are non-market specific) and an application-specific set (i.e., knowledge of the application that is therefore market specific). Although all markets require both sets of capabilities to execute R& D, prior research has analyzed cases where the application was not as complex, and therefore application-specific capabilities did not represent strategic factors. Because at the start of a technological discontinuity application-specific capabilities are undestroyed and have accrued only to incumbents, when complex enough, these capabilities can represent a source of competitive advantage for these firms, even in the face of competition from diversifying entrants reusing previously acquired technological platforms. I find evidence consistent with my proposition based on data on outcomes from drug discovery (as estimated through clinical endpoints in phase I trials) for firms competing in the anticancer drug market, one of the most complex markets within pharmaceuticals, as the market transitions into the biotechnology revolution. The proposition in this paper implies that although technological platforms can help firms move across markets, application-specific R& D capabilities can help firms retain leadership within a market across technological discontinuities.

Suggested Citation

  • M. Lourdes Sosa, 2009. "Application-Specific R& D Capabilities and the Advantage of Incumbents: Evidence from the Anticancer Drug Market," Management Science, INFORMS, vol. 55(8), pages 1409-1422, August.
  • Handle: RePEc:inm:ormnsc:v:55:y:2009:i:8:p:1409-1422
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    File URL: http://dx.doi.org/10.1287/mnsc.1090.1027
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    1. David J. TEECE, 2008. "Profiting from technological innovation: Implications for integration, collaboration, licensing and public policy," World Scientific Book Chapters,in: The Transfer And Licensing Of Know-How And Intellectual Property Understanding the Multinational Enterprise in the Modern World, chapter 5, pages 67-87 World Scientific Publishing Co. Pte. Ltd..
    2. Pierre Azoulay, 2004. "Capturing Knowledge within and across Firm Boundaries: Evidence from Clinical Development," American Economic Review, American Economic Association, vol. 94(5), pages 1591-1612, December.
    3. Z. John Lu & William S. Comanor, 1998. "Strategic Pricing Of New Pharmaceuticals," The Review of Economics and Statistics, MIT Press, vol. 80(1), pages 108-118, February.
    4. Stuart, Graham & Higgins, Matthew, 2007. "The Impact of Patenting on New Product Introductions in the Pharmaceutical Industry," MPRA Paper 4574, University Library of Munich, Germany.
    5. Rebecca Henderson, 1993. "Underinvestment and Incompetence as Responses to Radical Innovation: Evidence from the Photolithographic Alignment Equipment Industry," RAND Journal of Economics, The RAND Corporation, vol. 24(2), pages 248-270, Summer.
    6. Cooper, Arnold C. & Schendel, Dan, 1976. "Strategic responses to technological threats," Business Horizons, Elsevier, vol. 19(1), pages 61-69, February.
    7. Sigelman, Lee & Zeng, Langche, 1999. "Analyzing Censored and Sample-Selected Data with Tobit and Heckit Models," Political Analysis, Cambridge University Press, vol. 8(02), pages 167-182, December.
    8. Papke, Leslie E & Wooldridge, Jeffrey M, 1996. "Econometric Methods for Fractional Response Variables with an Application to 401(K) Plan Participation Rates," Journal of Applied Econometrics, John Wiley & Sons, Ltd., vol. 11(6), pages 619-632, Nov.-Dec..
    9. Montgomery, Cynthia A. & Hariharan, S., 1991. "Diversified expansion by large established firms," Journal of Economic Behavior & Organization, Elsevier, vol. 15(1), pages 71-89, January.
    10. Brian S. Silverman, 1999. "Technological Resources and the Direction of Corporate Diversification: Toward an Integration of the Resource-Based View and Transaction Cost Economics," Management Science, INFORMS, vol. 45(8), pages 1109-1124, August.
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    1. repec:eee:tefoso:v:120:y:2017:i:c:p:130-143 is not listed on IDEAS
    2. repec:bla:stratm:v:38:y:2017:i:9:p:1791-1811 is not listed on IDEAS
    3. Peeters, T.J.G., 2013. "External knowledge search and use in new product development," Other publications TiSEM 300ebb34-b090-4210-b95e-f, Tilburg University, School of Economics and Management.
    4. Yang, Chia-Hsuan & Nugent, Rebecca & Fuchs, Erica R.H., 2016. "Gains from others’ losses: Technology trajectories and the global division of firms," Research Policy, Elsevier, vol. 45(3), pages 724-745.
    5. Martzoukos, Spiros H. & Zacharias, Eleftherios, 2013. "Real option games with R&D and learning spillovers," Omega, Elsevier, vol. 41(2), pages 236-249.
    6. repec:oup:indcch:v:26:y:2017:i:4:p:709-726. is not listed on IDEAS

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