IDEAS home Printed from https://ideas.repec.org/a/eee/jeborg/v86y2013icp148-168.html
   My bibliography  Save this article

Drug withdrawals and the utilization of therapeutic substitutes: The case of Vioxx

Author

Listed:
  • Collins, J. Michael
  • Simon, Kosali I.
  • Tennyson, Sharon

Abstract

The lack of research on how the 2004 safety-related withdrawal of the drug Vioxx affected consumer drug utilization or outcomes for competitors is a missed opportunity to learn from the largest drug withdrawal event in history. Our study fills this void using state-level repeated cross section data from the Medicaid State Drug Utilization (SDU) database of fee-for-service Medicaid claims for prescription drugs, and individual-level panel data from the Medical Expenditure Panel Survey (MEPS) which is a nationally representative survey that contains information on medication use across two years. We find that the withdrawal of Vioxx had both positive and negative effects for specific substitute drugs in its own class (COX-2s), and that it led to an overall increase in the usage of both its most direct competitor class (NSAIDs) and in a class of older similar therapy (Analgesics). We argue these shifts in drug usage represent what could be viewed as an appropriate response to the events. However, aggregate use of drugs in the COX-2 and related classes declined overall, suggesting that some consumers may have over-reacted to the withdrawal events in ways that lessened the health benefits they could receive from this family of drugs. These findings about medication utilization changes in response to negative information are highly relevant for policy design and for determining thresholds for regulatory interventions.

Suggested Citation

  • Collins, J. Michael & Simon, Kosali I. & Tennyson, Sharon, 2013. "Drug withdrawals and the utilization of therapeutic substitutes: The case of Vioxx," Journal of Economic Behavior & Organization, Elsevier, vol. 86(C), pages 148-168.
  • Handle: RePEc:eee:jeborg:v:86:y:2013:i:c:p:148-168
    DOI: 10.1016/j.jebo.2012.12.006
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S016726811200265X
    Download Restriction: Full text for ScienceDirect subscribers only

    File URL: https://libkey.io/10.1016/j.jebo.2012.12.006?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Crafton, Steven M & Hoffer, George E & Reilly, Robert J, 1981. "Testing the Impact of Recalls on the Demand for Automobiles," Economic Inquiry, Western Economic Association International, vol. 19(4), pages 694-703, October.
    2. Olson, Mary K., 2008. "The risk we bear: The effects of review speed and industry user fees on new drug safety," Journal of Health Economics, Elsevier, vol. 27(2), pages 175-200, March.
    3. Craig L. Garthwaite, 2012. "The Economic Benefits of Pharmaceutical Innovations: The Case of Cox-2 Inhibitors," American Economic Journal: Applied Economics, American Economic Association, vol. 4(3), pages 116-137, July.
    4. Wesley A. Magat & W. Kip Viscusi, 1992. "Informational Approaches to Regulation," MIT Press Books, The MIT Press, edition 1, volume 1, number 026213277x.
    5. Pauline M. Ippolito & Alan D. Mathios, 1990. "Information, Advertising and Health Choices: A Study of the Cereal Market," RAND Journal of Economics, The RAND Corporation, vol. 21(3), pages 459-480, Autumn.
    6. Mathios, Alan D, 2000. "The Impact of Mandatory Disclosure Laws on Product Choices: An Analysis of the Salad Dressing Market," Journal of Law and Economics, University of Chicago Press, vol. 43(2), pages 651-677, October.
    7. V. Kerry Smith & William H. Desvousges & F. Reed Johnson & Ann Fisher, 1990. "Can public information programs affect risk perceptions?," Journal of Policy Analysis and Management, John Wiley & Sons, Ltd., vol. 9(1), pages 41-59.
    8. Keller, Kevin Lane & Staelin, Richard, 1987. "Effects of Quality and Quantity of Information on Decision Effectiveness," Journal of Consumer Research, Oxford University Press, vol. 14(2), pages 200-213, September.
    9. Soumerai, S.B. & Avorn, J. & Gortmaker, S. & Hawley, S., 1987. "Effect of government and commercial warnings on reducing prescription misuse: The case of propoxyphene," American Journal of Public Health, American Public Health Association, vol. 77(12), pages 1518-1523.
    10. Seth Freedman & Melissa Kearney & Mara Lederman, 2012. "Product Recalls, Imperfect Information, and Spillover Effects: Lessons from the Consumer Response to the 2007 Toy Recalls," The Review of Economics and Statistics, MIT Press, vol. 94(2), pages 499-516, May.
    11. Hoffer, George E & Pruitt, Stephen W & Reilly, Robert J, 1988. "The Impact of Product Recalls on the Wealth of Sellers: A Reexamination," Journal of Political Economy, University of Chicago Press, vol. 96(3), pages 663-670, June.
    12. Mitchell, Mark L, 1989. "The Impact of External Parties on Brand-Name Capital: The 1982 Tylenol Poisonings and Subsequent Cases," Economic Inquiry, Western Economic Association International, vol. 27(4), pages 601-618, October.
    13. Smith, V Kerry & Johnson, F Reed, 1988. "How Do Risk Perceptions Respond to Information? The Case of Radon," The Review of Economics and Statistics, MIT Press, vol. 70(1), pages 1-8, February.
    14. Steven T. Berry, 1994. "Estimating Discrete-Choice Models of Product Differentiation," RAND Journal of Economics, The RAND Corporation, vol. 25(2), pages 242-262, Summer.
    15. Sophie Hieke & Charles R. Taylor, 2012. "A Critical Review of the Literature on Nutritional Labeling," Journal of Consumer Affairs, Wiley Blackwell, vol. 46(1), pages 120-156, March.
    16. Russo, J. Edward & Medvec, Victoria Husted & Meloy, Margaret G., 1996. "The Distortion of Information during Decisions," Organizational Behavior and Human Decision Processes, Elsevier, vol. 66(1), pages 102-110, April.
    17. Jarrell, Gregg & Peltzman, Sam, 1985. "The Impact of Product Recalls on the Wealth of Sellers," Journal of Political Economy, University of Chicago Press, vol. 93(3), pages 512-536, June.
    18. Malhotra, Naresh K, 1982. "Information Load and Consumer Decision Making," Journal of Consumer Research, Oxford University Press, vol. 8(4), pages 419-430, March.
    19. Dranove, David & Olsen, Chris, 1994. "The Economic Side Effects of Dangerous Drug Announcements," Journal of Law and Economics, University of Chicago Press, vol. 37(2), pages 323-348, October.
    20. Suresh Govindaraj & Bikki Jaggi & Beixin Lin, 2004. "Market Overreaction to Product Recall Revisited--The Case of Firestone Tires and the Ford Explorer," Review of Quantitative Finance and Accounting, Springer, vol. 23(1), pages 31-54, July.
    21. Pierre Azoulay, 2002. "Do Pharmaceutical Sales Respond to Scientific Evidence?," Journal of Economics & Management Strategy, Wiley Blackwell, vol. 11(4), pages 551-594, December.
    22. W. Kip Viscusi & Wesley A. Magat & Joel Huber, 1986. "Informational Regulation of Consumer Health Risks: An Empirical Evaluation of Hazard Warnings," RAND Journal of Economics, The RAND Corporation, vol. 17(3), pages 351-365, Autumn.
    23. Hartman, Raymond S, 1987. "Product Quality and Market Efficiency: The Effect of Product Recalls on Resale Prices and Firm Valuation," The Review of Economics and Statistics, MIT Press, vol. 69(2), pages 367-372, May.
    24. Heiman, Amir & Lowengart, Oded, 2008. "The effect of information about health hazards on demand for frequently purchased commodities," International Journal of Research in Marketing, Elsevier, vol. 25(4), pages 310-318.
    25. Magat, Wesley A & Viscusi, W Kip & Huber, Joel, 1988. "Consumer Processing of Hazard Warning Information," Journal of Risk and Uncertainty, Springer, vol. 1(2), pages 201-232, June.
    26. Kosali Simon & Sharon Tennyson & Julie Hudman, 2009. "Do State Cost Control Policies Reduce Medicaid Prescription Drug Spending?," Risk Management and Insurance Review, American Risk and Insurance Association, vol. 12(1), pages 39-66, March.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Aline Bütikofer & Meghan M. Skira, 2018. "Missing Work Is a Pain: The Effect of Cox-2 Inhibitors on Sickness Absence and Disability Pension Receipt," Journal of Human Resources, University of Wisconsin Press, vol. 53(1), pages 71-122.
    2. Bütikofer, Aline & Cronin, Christopher J. & Skira, Meghan M., 2020. "Employment effects of healthcare policy: Evidence from the 2007 FDA black box warning on antidepressants," Journal of Health Economics, Elsevier, vol. 73(C).
    3. Zec, Dejan & Rüling, Charles-Clemens & Wang, Tao, 2020. "Parliament in action: Drug withdrawals and policy changes in the U.K," Health Policy, Elsevier, vol. 124(9), pages 984-990.
    4. Dubois, Pierre & Tuncel, Tuba, 2020. "Identifying the Effects of Scientific Information and Recommendations on Physicians’ Prescribing Behavior," TSE Working Papers 20-1114, Toulouse School of Economics (TSE).
    5. John Romley & Tiffany Shih, 2017. "Product safety spillovers and market viability for biologic drugs," International Journal of Health Economics and Management, Springer, vol. 17(2), pages 135-158, June.
    6. Sumedha Gupta & Thuy D. Nguyen & Patricia R. Freeman & Kosali I. Simon, 2020. "Competitive Effects of Federal and State Opioid Restrictions: Evidence from the Controlled Substance Laws," NBER Working Papers 27520, National Bureau of Economic Research, Inc.
    7. Ram Bala & Pradeep Bhardwaj & Pradeep K. Chintagunta, 2017. "Pharmaceutical Product Recalls: Category Effects and Competitor Response," Marketing Science, INFORMS, vol. 36(6), pages 931-943, November.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Gokhale, Jayendra & Brooks, Raymond M. & Tremblay, Victor J., 2014. "The effect on stockholder wealth of product recalls and government action: The case of Toyota's accelerator pedal recall," The Quarterly Review of Economics and Finance, Elsevier, vol. 54(4), pages 521-528.
    2. Seth Freedman & Melissa Kearney & Mara Lederman, 2012. "Product Recalls, Imperfect Information, and Spillover Effects: Lessons from the Consumer Response to the 2007 Toy Recalls," The Review of Economics and Statistics, MIT Press, vol. 94(2), pages 499-516, May.
    3. Eng Cheah & Wen Chan & Corinne Chieng, 2007. "The Corporate Social Responsibility of Pharmaceutical Product Recalls: An Empirical Examination of U.S. and U.K. Markets," Journal of Business Ethics, Springer, vol. 76(4), pages 427-449, December.
    4. Unsal, Omer & Hassan, M. Kabir & Zirek, Duygu, 2017. "Product recalls and security prices: New evidence from the US market," Journal of Economics and Business, Elsevier, vol. 93(C), pages 62-79.
    5. Bates, Hilary & Holweg, Matthias & Lewis, Michael & Oliver, Nick, 2007. "Motor vehicle recalls: Trends, patterns and emerging issues," Omega, Elsevier, vol. 35(2), pages 202-210, April.
    6. Ater, Itai & Yosef, Nir, 2018. "The Impact of Product Recalls on the Secondary Market:Evidence from Dieselgate," CEPR Discussion Papers 12899, C.E.P.R. Discussion Papers.
    7. Allais, Olivier & Etilé, Fabrice & Lecocq, Sébastien, 2015. "Mandatory labels, taxes and market forces: An empirical evaluation of fat policies," Journal of Health Economics, Elsevier, vol. 43(C), pages 27-44.
    8. Graham Beattie & Ruben Durante & Brian Knight & Ananya Sen, 2021. "Advertising Spending and Media Bias: Evidence from News Coverage of Car Safety Recalls," Management Science, INFORMS, vol. 67(2), pages 698-719, February.
    9. Kathleen Cleeren & Marnik G. Dekimpe & Harald J. Heerde, 2017. "Marketing research on product-harm crises: a review, managerial implications, and an agenda for future research," Journal of the Academy of Marketing Science, Springer, vol. 45(5), pages 593-615, September.
    10. Rosa Ferrer Zarzuela & Helena Perrone, 2017. "Consumers’ costly responses to product-harm crises," Economics Working Papers 1571, Department of Economics and Business, Universitat Pompeu Fabra.
    11. Shimshack, Jay P. & Ward, Michael B. & Beatty, Timothy K.M., 2007. "Mercury advisories: Information, education, and fish consumption," Journal of Environmental Economics and Management, Elsevier, vol. 53(2), pages 158-179, March.
    12. Yongmin Chen & Xinyu Hua, 2012. "Ex Ante Investment, Ex Post Remedies, And Product Liability," International Economic Review, Department of Economics, University of Pennsylvania and Osaka University Institute of Social and Economic Research Association, vol. 53(3), pages 845-866, August.
    13. Hoehn, John P. & Randall, Alan, 2002. "The effect of resource quality information on resource injury perceptions and contingent values," Resource and Energy Economics, Elsevier, vol. 24(1-2), pages 13-31, February.
    14. Andrew Cooke & Wendy Chapple, 1998. "Guilty by Association? The Case of The Karin B Scare," European Journal of Law and Economics, Springer, vol. 5(1), pages 5-12, January.
    15. W. Kip Viscusi & Richard J. Zeckhauser, 2015. "The Relative Weights of Direct and Indirect Experiences in the Formation of Environmental Risk Beliefs," Risk Analysis, John Wiley & Sons, vol. 35(2), pages 318-331, February.
    16. Kong, Dongmin & Shi, Lu & Yang, Zhiqing, 2019. "Product recalls, corporate social responsibility, and firm value: Evidence from the Chinese food industry," Food Policy, Elsevier, vol. 83(C), pages 60-69.
    17. Hugo Benitez-Silva & Yong-Kyun Bae, 2013. "Information Transmission and Vehicle Recalls: The Role and Regulation of Recall Notification Letter," Department of Economics Working Papers 13-02, Stony Brook University, Department of Economics.
    18. Pozo, Veronica F. & Schroeder, Ted C., 2016. "Evaluating the costs of meat and poultry recalls to food firms using stock returns," Food Policy, Elsevier, vol. 59(C), pages 66-77.
    19. Higgins, Matthew J. & Yan, Xin & Chatterjee, Chirantan, 2021. "Unpacking the effects of adverse regulatory events: Evidence from pharmaceutical relabeling," Research Policy, Elsevier, vol. 50(1).
    20. Kristy Parkinson & Joseph Price & Kosali Simon & Sharon Tennyson, 2014. "The influence of FDA advisory information and black box warnings on individual use of prescription antidepressants," Review of Economics of the Household, Springer, vol. 12(4), pages 771-790, December.

    More about this item

    Keywords

    Drug withdrawals; Vioxx;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:jeborg:v:86:y:2013:i:c:p:148-168. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: . General contact details of provider: http://www.elsevier.com/locate/jebo .

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/locate/jebo .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service hosted by the Research Division of the Federal Reserve Bank of St. Louis . RePEc uses bibliographic data supplied by the respective publishers.