IDEAS home Printed from https://ideas.repec.org/a/gam/jsusta/v12y2020i6p2456-d334992.html
   My bibliography  Save this article

Evolution of Guangzhou Biomedical Industry Innovation Network Structure and Its Proximity Mechanism

Author

Listed:
  • Kaihuang Zhang

    (School of Geographical Sciences, Guangzhou University, Guangzhou 510006 China)

  • Qinglan Qian

    (School of Geographical Sciences, Guangzhou University, Guangzhou 510006 China)

  • Yijing Zhao

    (Guangzhou Lingnan Architecture Research Center, Guangzhou 510030, China)

Abstract

The topological structure and multidimensional proximity evolution mechanism of Guangzhou biomedical industry innovation network are studied by using cooperative patents and cooperative papers from 1998 to 2018 with Ucinet and PLS-SEM. Research shows: ① The evolution of the Guangzhou Biomedical Industry Innovation Network can be divided into three stages, which are the primary budding stage of 1998–2005, the steady development stage of 2006–2012, and the rapid development stage of 2013–2018; ② the number of subjects in the innovation network is increasing, and the types of subjects are constantly increasing. The innovation network has gone from small to large, from closed to open, and from simple to complex. Patents and papers cooperation networks show different characteristics at various stages; ③ the relationship between geographical proximity, cognitive proximity, organizational proximity, and innovation network differs in stages. The interaction of proximity varies with the content of innovation cooperation. Based on this result, we have put forward policy recommendations for different innovative content.

Suggested Citation

  • Kaihuang Zhang & Qinglan Qian & Yijing Zhao, 2020. "Evolution of Guangzhou Biomedical Industry Innovation Network Structure and Its Proximity Mechanism," Sustainability, MDPI, vol. 12(6), pages 1-20, March.
    • Handle: RePEc:gam:jsusta:v:12:y:2020:i:6:p:2456-:d:334992
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/2071-1050/12/6/2456/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/2071-1050/12/6/2456/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Bjørn Asheim, 2012. "The Changing Role of Learning Regions in the Globalizing Knowledge Economy: A Theoretical Re-examination," Regional Studies, Taylor & Francis Journals, vol. 46(8), pages 993-1004, June.
    2. Jason Owen‐Smith & Christopher Thomas Scott & Jennifer B. McCormick, 2012. "Expand and Regularize Federal Funding for Human Pluripotent Stem Cell Research," Journal of Policy Analysis and Management, John Wiley & Sons, Ltd., vol. 31(3), pages 714-722, June.
    3. Elfring, Tom & Hulsink, Willem, 2003. "Networks in Entrepreneurship: The Case of High-Technology Firms," Small Business Economics, Springer, vol. 21(4), pages 409-422, December.
    4. Jensen, Morten Berg & Johnson, Bjorn & Lorenz, Edward & Lundvall, Bengt Ake, 2007. "Forms of knowledge and modes of innovation," Research Policy, Elsevier, vol. 36(5), pages 680-693, June.
    5. Anne L.J. Ter Wal, 2013. "Cluster Emergence and Network Evolution: A Longitudinal Analysis of the Inventor Network in Sophia-Antipolis," Regional Studies, Taylor & Francis Journals, vol. 47(5), pages 651-668, May.
    6. Holger Graf & Jens Kruger, 2011. "The Performance of Gatekeepers in Innovator Networks," Industry and Innovation, Taylor & Francis Journals, vol. 18(1), pages 69-88.
    7. Peter Maskell, 2001. "The Firm in Economic Geography," Economic Geography, Taylor & Francis Journals, vol. 77(4), pages 329-344, October.
    8. Paul Almeida & Bruce Kogut, 1999. "Localization of Knowledge and the Mobility of Engineers in Regional Networks," Management Science, INFORMS, vol. 45(7), pages 905-917, July.
    9. Basberg, Bjorn L., 1987. "Patents and the measurement of technological change: A survey of the literature," Research Policy, Elsevier, vol. 16(2-4), pages 131-141, August.
    10. Ron A. Boschma & Jan G. Lambooy, 2002. "Knowledge, Market Structure, and Economic Coordination: Dynamics of Industrial Districts," Growth and Change, Wiley Blackwell, vol. 33(3), pages 291-311.
    11. Ekaterina Turkina & Ari Van Assche & Raja Kali, 2016. "Structure and evolution of global cluster networks: evidence from the aerospace industry," Journal of Economic Geography, Oxford University Press, vol. 16(6), pages 1211-1234.
    12. Johannes Glückler & Patrick Doreian, 2016. "Editorial: social network analysis and economic geography—positional, evolutionary and multi-level approaches," Journal of Economic Geography, Oxford University Press, vol. 16(6), pages 1123-1134.
    13. Yingcheng Li & Xingping Wang, 2019. "Innovation in suburban development zones: Evidence from Nanjing, China," Growth and Change, Wiley Blackwell, vol. 50(1), pages 114-129, March.
    14. Thomas Scherngell & Yuanjia Hu, 2011. "Collaborative Knowledge Production in China: Regional Evidence from a Gravity Model Approach," Regional Studies, Taylor & Francis Journals, vol. 45(6), pages 755-772.
    15. Holger Graf & Tobias Henning, 2010. "Public Research in Regional Networks of Innovators: A Comparative Study of Four East-German Regions," Springer Books, in: Andreas Freytag & Roy Thurik (ed.), Entrepreneurship and Culture, chapter 0, pages 97-128, Springer.
    16. Nooteboom, Bart & Van Haverbeke, Wim & Duysters, Geert & Gilsing, Victor & van den Oord, Ad, 2007. "Optimal cognitive distance and absorptive capacity," Research Policy, Elsevier, vol. 36(7), pages 1016-1034, September.
    17. Adam B. Jaffe & Manuel Trajtenberg & Rebecca Henderson, 1993. "Geographic Localization of Knowledge Spillovers as Evidenced by Patent Citations," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 108(3), pages 577-598.
    18. Asheim, Bjorn T & Isaksen, Arne, 2002. "Regional Innovation Systems: The Integration of Local 'Sticky' and Global 'Ubiquitous' Knowledge," The Journal of Technology Transfer, Springer, vol. 27(1), pages 77-86, January.
    19. Nina Liu & Jiwu Wang & Yan Song, 2019. "Organization Mechanisms and Spatial Characteristics of Urban Collaborative Innovation Networks: A Case Study in Hangzhou, China," Sustainability, MDPI, vol. 11(21), pages 1-18, October.
    20. Binz, Christian & Truffer, Bernhard, 2017. "Global Innovation Systems—A conceptual framework for innovation dynamics in transnational contexts," Research Policy, Elsevier, vol. 46(7), pages 1284-1298.
    21. Jarno Hoekman & Koen Frenken & Frank Oort, 2009. "The geography of collaborative knowledge production in Europe," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 43(3), pages 721-738, September.
    22. Tom Broekel & Wladimir Mueller, 2018. "Critical links in knowledge networks – What about proximities and gatekeeper organisations?," Industry and Innovation, Taylor & Francis Journals, vol. 25(10), pages 919-939, November.
    23. Jili Xu & Fiona Fan Yang & Desheng Xue, 2019. "The Geography of Knowledge Sourcing, Personal Networks, and Innovation Effects: Evidence from the Biomedical Firms in Guangzhou, China," Sustainability, MDPI, vol. 11(12), pages 1-18, June.
    24. Graf, Holger & Kalthaus, Martin, 2018. "International research networks: Determinants of country embeddedness," Research Policy, Elsevier, vol. 47(7), pages 1198-1214.
    25. Pablo D'Este & Frederick Guy & Simona Iammarino, 2013. "Shaping the formation of university--industry research collaborations: what type of proximity does really matter?," Journal of Economic Geography, Oxford University Press, vol. 13(4), pages 537-558, July.
    26. Ron Martin & Peter Sunley, 2003. "Deconstructing clusters: chaotic concept or policy panacea?," Journal of Economic Geography, Oxford University Press, vol. 3(1), pages 5-35, January.
    27. Johan Miörner & Elena Zukauskaite & Michaela Trippl & Jerker Moodysson, 2018. "Creating institutional preconditions for knowledge flows in cross-border regions," Environment and Planning C, , vol. 36(2), pages 201-218, March.
    28. Pierre-Alexandre Balland & Mathijs De Vaan & Ron Boschma, 2013. "The dynamics of interfirm networks along the industry life cycle: The case of the global video game industry, 1987--2007," Journal of Economic Geography, Oxford University Press, vol. 13(5), pages 741-765, September.
    29. Yan Wang & Yishan Wu & Yuntao Pan & Zheng Ma & Ronald Rousseau, 2005. "Scientific collaboration in China as reflected in co-authorship," Scientometrics, Springer;Akadémiai Kiadó, vol. 62(2), pages 183-198, January.
    30. Pierre-Alexandre Balland & José Antonio Belso-Martínez & Andrea Morrison, 2016. "The Dynamics of Technical and Business Knowledge Networks in Industrial Clusters: Embeddedness, Status, or Proximity?," Economic Geography, Taylor & Francis Journals, vol. 92(1), pages 35-60, January.
    31. Ron Boschma & Anne L. J. ter Wal, 2007. "Knowledge Networks and Innovative Performance in an Industrial District: The Case of a Footwear District in the South of Italy," Industry and Innovation, Taylor & Francis Journals, vol. 14(2), pages 177-199.
    32. Giuliani, Elisa & Bell, Martin, 2005. "The micro-determinants of meso-level learning and innovation: evidence from a Chilean wine cluster," Research Policy, Elsevier, vol. 34(1), pages 47-68, February.
    33. Pierre-Alexandre Balland, 2012. "Proximity and the Evolution of Collaboration Networks: Evidence from Research and Development Projects within the Global Navigation Satellite System (GNSS) Industry," Regional Studies, Taylor & Francis Journals, vol. 46(6), pages 741-756, September.
    34. Hoekman, Jarno & Frenken, Koen & Tijssen, Robert J.W., 2010. "Research collaboration at a distance: Changing spatial patterns of scientific collaboration within Europe," Research Policy, Elsevier, vol. 39(5), pages 662-673, June.
    35. Ron Boschma, 2005. "Proximity and Innovation: A Critical Assessment," Regional Studies, Taylor & Francis Journals, vol. 39(1), pages 61-74.
    36. Bart Nooteboom, 2000. "Learning by Interaction: Absorptive Capacity, Cognitive Distance and Governance," Journal of Management & Governance, Springer;Accademia Italiana di Economia Aziendale (AIDEA), vol. 4(1), pages 69-92, March.
    37. Jason Owen-Smith & Walter W. Powell, 2004. "Knowledge Networks as Channels and Conduits: The Effects of Spillovers in the Boston Biotechnology Community," Organization Science, INFORMS, vol. 15(1), pages 5-21, February.
    38. Liang, Xinning & Liu, Anita M.M., 2018. "The evolution of government sponsored collaboration network and its impact on innovation: A bibliometric analysis in the Chinese solar PV sector," Research Policy, Elsevier, vol. 47(7), pages 1295-1308.
    39. Freeman, C., 1991. "Networks of innovators: A synthesis of research issues," Research Policy, Elsevier, vol. 20(5), pages 499-514, October.
    40. Andrea Caragliu & Peter Nijkamp, 2016. "Space and knowledge spillovers in European regions: the impact of different forms of proximity on spatial knowledge diffusion," Journal of Economic Geography, Oxford University Press, vol. 16(3), pages 749-774.
    41. Roderik Ponds & Frank Van Oort & Koen Frenken, 2007. "The geographical and institutional proximity of research collaboration," Papers in Regional Science, Wiley Blackwell, vol. 86(3), pages 423-443, August.
    42. Anne L. J. Ter Wal, 2014. "The dynamics of the inventor network in German biotechnology: geographic proximity versus triadic closure," Journal of Economic Geography, Oxford University Press, vol. 14(3), pages 589-620.
    43. Liming Liang & Ling Zhu, 2002. "Major factors affecting China's inter-regional research collaboration: Regional scientific productivity and geographical proximity," Scientometrics, Springer;Akadémiai Kiadó, vol. 55(2), pages 287-316, August.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Shu Yu & Takaya Yuizono, 2021. "A Proximity Approach to Understanding University-Industry Collaborations for Innovation in Non-Local Context: Exploring the Catch-Up Role of Regional Absorptive Capacity," Sustainability, MDPI, vol. 13(6), pages 1-19, March.
    2. Mingrui He & Min Mei & Handan Zhang, 2024. "Evolutionary Stages and Paths of Innovation Networks in Industrial Clusters: Case Study of Nanchong Silk-Spinning Garment Industry Cluster (SSGIC)," Journal of the Knowledge Economy, Springer;Portland International Center for Management of Engineering and Technology (PICMET), vol. 15(1), pages 1703-1735, March.
    3. Dongsheng Yan & Wei Sun, 2022. "Study on the Evolution, Driving Factors, and Regional Comparison of Innovation Patterns in the Yangtze River Delta," Land, MDPI, vol. 11(6), pages 1-21, June.
    4. Mingbo Sun & Xueqing Zhang & Xiaoxiao Zhang, 2022. "The Impact of a Multilevel Innovation Network and Government Support on Innovation Performance—An Empirical Study of the Chengdu–Chongqing City Cluster," Sustainability, MDPI, vol. 14(12), pages 1-17, June.
    5. Shin, Hyunjin & Woo, Hyun Goo & Sohn, Kyung-Ah & Lee, Sungjoo, 2023. "Comparing research trends with patenting activities in the biomedical sector: The case of dementia," Technological Forecasting and Social Change, Elsevier, vol. 195(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Pierre-Alexandre Balland & Ron Boschma & Koen Frenken, 2020. "Proximity, Innovation and Networks: A Concise Review and Some Next Steps," Papers in Evolutionary Economic Geography (PEEG) 2019, Utrecht University, Department of Human Geography and Spatial Planning, Group Economic Geography, revised Mar 2020.
    2. Pierre-Alexandre Balland & Ron Boschma & Koen Frenken, 2015. "Proximity and Innovation: From Statics to Dynamics," Regional Studies, Taylor & Francis Journals, vol. 49(6), pages 907-920, June.
    3. Tsouri, Maria & Hansen, Teis & Hanson, Jens & Steen, Markus, 2022. "Knowledge recombination for emerging technological innovations: The case of green shipping," Technovation, Elsevier, vol. 114(C).
    4. Koen Frenken & Roderik Ponds & Frank Van Oort, 2010. "The citation impact of research collaboration in science‐based industries: A spatial‐institutional analysis," Papers in Regional Science, Wiley Blackwell, vol. 89(2), pages 351-271, June.
    5. Maria Tsouri, 2022. "Knowledge networks and strong tie creation: the role of relative network position," Journal of Geographical Systems, Springer, vol. 24(1), pages 95-114, January.
    6. Uwe Cantner & Holger Graf, 2011. "Innovation Networks: Formation, Performance and Dynamics," Chapters, in: Cristiano Antonelli (ed.), Handbook on the Economic Complexity of Technological Change, chapter 15, Edward Elgar Publishing.
    7. Ron Boschma & Pierre-Alexandre Balland & Mathijs de Vaan, 2014. "The formation of economic networks: a proximity approach," Chapters, in: André Torre & Frédéric Wallet (ed.), Regional Development and Proximity Relations, chapter 7, pages 243-266, Edward Elgar Publishing.
    8. Morescalchi, Andrea & Pammolli, Fabio & Penner, Orion & Petersen, Alexander M. & Riccaboni, Massimo, 2015. "The evolution of networks of innovators within and across borders: Evidence from patent data," Research Policy, Elsevier, vol. 44(3), pages 651-668.
    9. Gallo, Julie Le & Plunket, Anne, 2020. "Regional gatekeepers, inventor networks and inventive performance: Spatial and organizational channels," Research Policy, Elsevier, vol. 49(5).
    10. Ana Fernández & Esther Ferrándiz & M. Dolores León, 2021. "Are organizational and economic proximity driving factors of scientific collaboration? Evidence from Spanish universities, 2001–2010," Scientometrics, Springer;Akadémiai Kiadó, vol. 126(1), pages 579-602, January.
    11. Tom Broekel & Marcel Bednarz, 2018. "Disentangling link formation and dissolution in spatial networks: An Application of a Two-Mode STERGM to a Project-Based R&D Network in the German Biotechnology Industry," Networks and Spatial Economics, Springer, vol. 18(3), pages 677-704, September.
    12. Pierre-Alexandre Balland & José Antonio Belso-Martínez & Andrea Morrison, 2014. "The Dynamics of Technical and Business Networks in Industrial Clusters: Embeddedness, status or proximity?," Papers in Evolutionary Economic Geography (PEEG) 1412, Utrecht University, Department of Human Geography and Spatial Planning, Group Economic Geography, revised Apr 2014.
    13. Grzegorz Micek, 2019. "Geographical Proximity Paradox Revisited: The Case of IT Service SMEs in Poland," Sustainability, MDPI, vol. 11(20), pages 1-18, October.
    14. Marie Ferru & Alain Rallet, 2016. "Proximity dynamics and the geography of innovation: diminishing returns or renewal?," Post-Print hal-02025328, HAL.
    15. Maria Tsouri, 2020. "Knowledge Networks and Strong Tie Creation: the Role of Relative Network Position," Papers in Evolutionary Economic Geography (PEEG) 2039, Utrecht University, Department of Human Geography and Spatial Planning, Group Economic Geography, revised Sep 2020.
    16. Der-Shiuan Lee, 2018. "Towards Urban Resilience through Inter-City Networks of Co-Invention: A Case Study of U.S. Cities," Sustainability, MDPI, vol. 10(2), pages 1-23, January.
    17. Matthias Firgo & Peter Mayerhofer, 2015. "Wissens-Spillovers und regionale Entwicklung - welche strukturpolitische Ausrichtung optimiert des Wachstum?," Working Paper Reihe der AK Wien - Materialien zu Wirtschaft und Gesellschaft 144, Kammer für Arbeiter und Angestellte für Wien, Abteilung Wirtschaftswissenschaft und Statistik.
    18. Laurent R. Bergé, 2017. "Network proximity in the geography of research collaboration," Papers in Regional Science, Wiley Blackwell, vol. 96(4), pages 785-815, November.
    19. Ferretti, Marco & Guerini, Massimiliano & Panetti, Eva & Parmentola, Adele, 2022. "The partner next door? The effect of micro-geographical proximity on intra-cluster inter-organizational relationships," Technovation, Elsevier, vol. 111(C).
    20. Tom Broekel & Wladimir Mueller, 2018. "Critical links in knowledge networks – What about proximities and gatekeeper organisations?," Industry and Innovation, Taylor & Francis Journals, vol. 25(10), pages 919-939, November.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jsusta:v:12:y:2020:i:6:p:2456-:d:334992. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.