IDEAS home Printed from https://ideas.repec.org/p/pra/mprapa/83392.html
   My bibliography  Save this paper

Modeling interregional research collaborations in German biotechnology using industry directory data: A quantitative social network analysis

Author

Listed:
  • Mitze, Timo
  • Strotebeck, Falk

Abstract

We use industry directory data as a novel source of information to model the strength of interregional research collaboration in German biotechnology. Specifically, we gather data on the number of research collaborations for biotech actors listed in the BIOCOM Year and Address book and aggregate this information to the level of German NUTS3 regions. This allows us to set up a modeling framework that treats individual regions as nodes of the biotech research network. We then specify the collaboration activity between regional nodes as a function of research and economic capacities at the regional level, the geographical proximity between regions, and policy variables. Our results show that the strength of interregional research collaboration can be related to both node properties and the relationship between nodes. As such, we find that modern locational factors are positively correlated with the extent of interregional research collaboration, while geographical distance is found to be an impediment to collaboration. The results further show that the pursuit of network and cluster policies in the biotech sector, particularly through collaborative R&D funding, is positively related to the strength of the interregional collaboration activity.

Suggested Citation

  • Mitze, Timo & Strotebeck, Falk, 2017. "Modeling interregional research collaborations in German biotechnology using industry directory data: A quantitative social network analysis," MPRA Paper 83392, University Library of Munich, Germany.
  • Handle: RePEc:pra:mprapa:83392
    as

    Download full text from publisher

    File URL: https://mpra.ub.uni-muenchen.de/83392/1/MPRA_paper_83392.pdf
    File Function: original version
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Broekel, Tom & Fornahl, Dirk & Morrison, Andrea, 2015. "Another cluster premium: Innovation subsidies and R&D collaboration networks," Research Policy, Elsevier, vol. 44(8), pages 1431-1444.
    2. Roberto Patuelli & Norbert Schanne & Daniel A. Griffith & Peter Nijkamp, 2012. "Persistence Of Regional Unemployment: Application Of A Spatial Filtering Approach To Local Labor Markets In Germany," Journal of Regional Science, Wiley Blackwell, vol. 52(2), pages 300-323, May.
    3. Christoph Grimpe & Roberto Patuelli, 2011. "Regional knowledge production in nanomaterials: a spatial filtering approach," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 46(3), pages 519-541, June.
    4. Adam B. Jaffe & Manuel Trajtenberg & Rebecca Henderson, 1993. "Geographic Localization of Knowledge Spillovers as Evidenced by Patent Citations," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 108(3), pages 577-598.
    5. Philip Cooke & Carla De Laurentis & Franz Tödtling & Michaela Trippl, 2007. "Regional Knowledge Economies," Books, Edward Elgar Publishing, number 3957.
    6. Dirk Engel & Timo Mitze & Roberto Patuelli & Janina Reinkowski, 2013. "Does Cluster Policy Trigger R&D Activity? Evidence from German Biotech Contests," European Planning Studies, Taylor & Francis Journals, vol. 21(11), pages 1735-1759, November.
    7. Raffaele Paci & Emanuela Marrocu & Stefano Usai, 2014. "The Complementary Effects of Proximity Dimensions on Knowledge Spillovers," Spatial Economic Analysis, Taylor & Francis Journals, vol. 9(1), pages 9-30, March.
    8. Martin, Philippe & Mayer, Thierry & Mayneris, Florian, 2011. "Public support to clusters: A firm level study of French "Local Productive Systems"," Regional Science and Urban Economics, Elsevier, vol. 41(2), pages 108-123, March.
    9. M. S. Gertler & Y. M. Levitte, 2005. "Local Nodes in Global Networks: The Geography of Knowledge Flows in Biotechnology Innovation," Industry and Innovation, Taylor & Francis Journals, vol. 12(4), pages 487-507.
    10. Falck, Oliver & Heblich, Stephan & Kipar, Stefan, 2010. "Industrial innovation: Direct evidence from a cluster-oriented policy," Regional Science and Urban Economics, Elsevier, vol. 40(6), pages 574-582, November.
    11. Breandán hUallacháin & Der-Shiuan Lee, 2014. "Urban centers and networks of co-invention in American biotechnology," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 52(3), pages 799-823, May.
    12. McCann, Philip, 2013. "Modern Urban and Regional Economics," OUP Catalogue, Oxford University Press, edition 2, number 9780199582006.
    13. Mario A. Maggioni & Mario Nosvelli & Teodora Erika Uberti, 2007. "Space versus networks in the geography of innovation: A European analysis," Papers in Regional Science, Wiley Blackwell, vol. 86(3), pages 471-493, August.
    14. Cilem Hazir & Corinne Autant-Bernard, 2014. "Determinants of cross-regional R&D collaboration: some empirical evidence from Europe in biotechnology," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 53(2), pages 369-393, September.
    15. Andrew K. Rose, 2004. "Do We Really Know That the WTO Increases Trade?," American Economic Review, American Economic Association, vol. 94(1), pages 98-114, March.
    16. Tom Broekel, 2015. "Do Cooperative Research and Development (R&D) Subsidies Stimulate Regional Innovation Efficiency? Evidence from Germany," Regional Studies, Taylor & Francis Journals, vol. 49(7), pages 1087-1110, July.
    17. repec:hal:wpspec:info:hdl:2441/c8dmi8nm4pdjkuc9g8mc0ghsn is not listed on IDEAS
    18. Björn Alecke & Christoph Alsleben & Frank Scharr & Gerhard Untiedt, 2006. "Are there really high-tech clusters? The geographic concentration of German manufacturing industries and its determinants," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 40(1), pages 19-42, March.
    19. Vuong, Quang H, 1989. "Likelihood Ratio Tests for Model Selection and Non-nested Hypotheses," Econometrica, Econometric Society, vol. 57(2), pages 307-333, March.
    20. Dirk Fornahl & Tom Broekel & Ron Boschma, 2011. "What drives patent performance of German biotech firms? The impact of R&D subsidies, knowledge networks and their location," Papers in Regional Science, Wiley Blackwell, vol. 90(2), pages 395-418, June.
    21. Uwe Cantner & Holger Graf, 2004. "Cooperation and specialization in German technology regions," Journal of Evolutionary Economics, Springer, vol. 14(5), pages 543-562, December.
    22. Baptista, Rui & Swann, Peter, 1998. "Do firms in clusters innovate more?," Research Policy, Elsevier, vol. 27(5), pages 525-540, September.
    23. Anne L. J. Ter Wal, 2014. "The dynamics of the inventor network in German biotechnology: geographic proximity versus triadic closure," Journal of Economic Geography, Oxford University Press, vol. 14(3), pages 589-620.
    24. Tom Broekel & Thomas Brenner, 2011. "Regional factors and innovativeness: an empirical analysis of four German industries," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 47(1), pages 169-194, August.
    25. repec:hal:spmain:info:hdl:2441/c8dmi8nm4pdjkuc9g8mc0ghsn is not listed on IDEAS
    26. Thomas Scherngell & Michael J. Barber, 2009. "Spatial interaction modelling of cross‐region R&D collaborations: empirical evidence from the 5th EU framework programme," Papers in Regional Science, Wiley Blackwell, vol. 88(3), pages 531-546, August.
    27. Daniel A. Griffith, 2003. "Spatial Autocorrelation and Spatial Filtering," Advances in Spatial Science, Springer, number 978-3-540-24806-4, Fall.
    28. Stefan Töpfer & Uwe Cantner & Holger Graf, 2019. "Structural dynamics of innovation networks in German Leading-Edge Clusters," The Journal of Technology Transfer, Springer, vol. 44(6), pages 1816-1839, December.
    29. Stefano Breschi & Francesco Lissoni, 2009. "Mobility of skilled workers and co-invention networks: an anatomy of localized knowledge flows," Journal of Economic Geography, Oxford University Press, vol. 9(4), pages 439-468, July.
    30. Iris Wanzenb�ck & Thomas Scherngell & Rafael Lata, 2015. "Embeddedness of European Regions in European Union-Funded Research and Development (R&D) Networks: A Spatial Econometric Perspective," Regional Studies, Taylor & Francis Journals, vol. 49(10), pages 1685-1705, October.
    31. Ron Boschma, 2005. "Proximity and Innovation: A Critical Assessment," Regional Studies, Taylor & Francis Journals, vol. 39(1), pages 61-74.
    32. Iris Wanzenböck & Thomas Scherngell & Thomas Brenner, 2014. "Embeddedness of regions in European knowledge networks: a comparative analysis of inter-regional R&D collaborations, co-patents and co-publications," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 53(2), pages 337-368, September.
    33. Michael Fritsch & Muhamed Kudic, 2016. "Preferential Attachment and Pattern Formation in R&D Networks - Plausible explanation or just a widespread myth?," Jena Economics Research Papers 2016-005, Friedrich-Schiller-University Jena.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mitze, Timo & Strotebeck, Falk, 2019. "Determining factors of interregional research collaboration in Germany's biotech network: Capacity, proximity, policy?," Technovation, Elsevier, vol. 80, pages 40-53.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Mitze, Timo & Strotebeck, Falk, 2019. "Determining factors of interregional research collaboration in Germany's biotech network: Capacity, proximity, policy?," Technovation, Elsevier, vol. 80, pages 40-53.
    2. Timo Mitze & Falk Strotebeck, 2012. "What Drives Regional Cooperative Behavior in German Biotechnology? Embedding Social Network Analysis in a Regression Framework," ERSA conference papers ersa12p629, European Regional Science Association.
    3. Graf, Holger & Broekel, Tom, 2020. "A shot in the dark? Policy influence on cluster networks," Research Policy, Elsevier, vol. 49(3).
    4. Marcel Bednarz & Tom Broekel, 2019. "The relationship of policy induced R&D networks and inter-regional knowledge diffusion," Journal of Evolutionary Economics, Springer, vol. 29(5), pages 1459-1481, November.
    5. Janina Reinkowski, 2014. "Empirical Essays in the Economics of Ageing and the Economics of Innovation," ifo Beiträge zur Wirtschaftsforschung, ifo Institute - Leibniz Institute for Economic Research at the University of Munich, number 53.
    6. Dirk Engel & Timo Mitze & Roberto Patuelli & Janina Reinkowski, 2013. "Does Cluster Policy Trigger R&D Activity? Evidence from German Biotech Contests," European Planning Studies, Taylor & Francis Journals, vol. 21(11), pages 1735-1759, November.
    7. Gergő Tóth & Sándor Juhász & Zoltán Elekes & Balázs Lengyel, 2021. "Repeated collaboration of inventors across European regions," European Planning Studies, Taylor & Francis Journals, vol. 29(12), pages 2252-2272, December.
    8. Dirk Engel & Timo Mitze & Roberto Patuelli & Janina Reinkowski, 2013. "Does Cluster Policy Trigger R&D Activity? Evidence from German Biotech Contests," European Planning Studies, Taylor & Francis Journals, vol. 21(11), pages 1735-1759, November.
    9. repec:zbw:rwirep:0311 is not listed on IDEAS
    10. Ernest Miguélez & Rosina Moreno, 2013. "Do Labour Mobility and Technological Collaborations Foster Geographical Knowledge Diffusion? The Case of European Regions," Growth and Change, Wiley Blackwell, vol. 44(2), pages 321-354, June.
    11. Ernest Miguele & Rosina Moreno, 2012. "Do labour mobility and networks foster geographical knowledge diffusion? The case of European regions," Working Papers XREAP2012-14, Xarxa de Referència en Economia Aplicada (XREAP), revised Jul 2012.
    12. Pierre-Alexandre Balland & Ron Boschma & Julien Ravet, 2019. "Network dynamics in collaborative research in the EU, 2003–2017," European Planning Studies, Taylor & Francis Journals, vol. 27(9), pages 1811-1837, September.
    13. Stefano Basilico & Uwe Cantner & Holger Graf, 2023. "Policy influence in the knowledge space: a regional application," The Journal of Technology Transfer, Springer, vol. 48(2), pages 591-622, April.
    14. Mario Maggioni & Teodora Uberti & Mario Nosvelli, 2014. "Does intentional mean hierarchical? Knowledge flows and innovative performance of European regions," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 53(2), pages 453-485, September.
    15. Iris Wanzenböck, 2016. "Measuring network proximity of regions in R&D networks," Innovation Studies Utrecht (ISU) working paper series 16-03, Utrecht University, Department of Innovation Studies, revised Nov 2016.
    16. Lorenzo Cassi & Anne Plunket, 2014. "Proximity, network formation and inventive performance: in search of the proximity paradox," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 53(2), pages 395-422, September.
    17. Laurent R. Bergé, 2017. "Network proximity in the geography of research collaboration," Papers in Regional Science, Wiley Blackwell, vol. 96(4), pages 785-815, November.
    18. Stefano Usai & Emanuela Marrocu & Raffaele Paci, 2017. "Networks, Proximities, and Interfirm Knowledge Exchanges," International Regional Science Review, , vol. 40(4), pages 377-404, July.
    19. Mariia Shkolnykova & Muhamed Kudic, 2022. "Who benefits from SMEs’ radical innovations?—empirical evidence from German biotechnology," Small Business Economics, Springer, vol. 58(2), pages 1157-1185, February.
    20. Di Cagno, Daniela & Fabrizi, Andrea & Meliciani, Valentina & Wanzenböck, Iris, 2016. "The impact of relational spillovers from joint research projects on knowledge creation across European regions," Technological Forecasting and Social Change, Elsevier, vol. 108(C), pages 83-94.
    21. Lorenzo CASSI & Emilie-Pauline GALLIÉ & Agénor LAHATTE & Valérie MERINDOL, 2018. "Scientific network centrality of European regions: the role of territorial resources," Region et Developpement, Region et Developpement, LEAD, Universite du Sud - Toulon Var, vol. 47, pages 5-26.

    More about this item

    Keywords

    Biotechnology; research collaboration; cluster policy; social network analysis; count data;
    All these keywords.

    JEL classification:

    • C21 - Mathematical and Quantitative Methods - - Single Equation Models; Single Variables - - - Cross-Sectional Models; Spatial Models; Treatment Effect Models
    • L65 - Industrial Organization - - Industry Studies: Manufacturing - - - Chemicals; Rubber; Drugs; Biotechnology; Plastics
    • O38 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - Government Policy
    • R38 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - Real Estate Markets, Spatial Production Analysis, and Firm Location - - - Government Policy

    NEP fields

    This paper has been announced in the following NEP Reports:

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:pra:mprapa:83392. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Joachim Winter (email available below). General contact details of provider: https://edirc.repec.org/data/vfmunde.html .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.