IDEAS home Printed from https://ideas.repec.org/a/eee/techno/v80-81y2019ip40-53.html
   My bibliography  Save this article

Determining factors of interregional research collaboration in Germany's biotech network: Capacity, proximity, policy?

Author

Listed:
  • Mitze, Timo
  • Strotebeck, Falk

Abstract

This paper analyses the determinants of link formation in Germany's biotech research network. Given the significance of regional clusters in the national biotech landscape, the modeling framework adopts a regional perspective and uses small-scale NUTS3 regions as nodes of the national biotech network. Linkages between nodes are measured by the number of active research collaborations between biotech actors located in these regions. The degree of the interregional collaboration activity between regional nodes is modeled as a function of the regions’ research and economic capabilities, the geographical distance between regions, and a set of policy variables. The empirical results from count data regressions show that link formation is significantly related to both node properties and the relationship between nodes. While locational factors such as regional high-tech start-up rates, the endowment with MINT employees and the population density as a broad measure for agglomeration economies are positively correlated with the extent of interregional research collaboration, distance acts an impediment to interregional collaboration. The results further show that the pursuit of network and cluster policies in the biotech sector, particularly through collaborative R&D funding, positively affects the strength of interregional collaboration activities.

Suggested Citation

  • Mitze, Timo & Strotebeck, Falk, 2019. "Determining factors of interregional research collaboration in Germany's biotech network: Capacity, proximity, policy?," Technovation, Elsevier, vol. 80, pages 40-53.
  • Handle: RePEc:eee:techno:v:80-81:y:2019:i::p:40-53
    DOI: 10.1016/j.technovation.2018.11.001
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0166497216301419
    Download Restriction: Full text for ScienceDirect subscribers only

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Broekel, Tom & Fornahl, Dirk & Morrison, Andrea, 2015. "Another cluster premium: Innovation subsidies and R&D collaboration networks," Research Policy, Elsevier, vol. 44(8), pages 1431-1444.
    2. repec:zbw:rwimat:021 is not listed on IDEAS
    3. repec:spo:wpecon:info:hdl:2441/c8dmi8nm4pdjkuc9g8mc0ghsn is not listed on IDEAS
    4. Tom Broekel, 2015. "Do Cooperative Research and Development (R&D) Subsidies Stimulate Regional Innovation Efficiency? Evidence from Germany," Regional Studies, Taylor & Francis Journals, vol. 49(7), pages 1087-1110, July.
    5. Roberto Patuelli & Norbert Schanne & Daniel A. Griffith & Peter Nijkamp, 2012. "Persistence Of Regional Unemployment: Application Of A Spatial Filtering Approach To Local Labor Markets In Germany," Journal of Regional Science, Wiley Blackwell, vol. 52(2), pages 300-323, May.
    6. Stefano Breschi & Francesco Lissoni, 2004. "Knowledge networks from patent data: Methodological issues and research targets," KITeS Working Papers 150, KITeS, Centre for Knowledge, Internationalization and Technology Studies, Universita' Bocconi, Milano, Italy, revised Jan 2004.
    7. Christoph Grimpe & Roberto Patuelli, 2011. "Regional knowledge production in nanomaterials: a spatial filtering approach," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 46(3), pages 519-541, June.
    8. Andrew K. Rose, 2004. "Do We Really Know That the WTO Increases Trade?," American Economic Review, American Economic Association, vol. 94(1), pages 98-114, March.
    9. Björn Alecke & Christoph Alsleben & Frank Scharr & Gerhard Untiedt, 2006. "Are there really high-tech clusters? The geographic concentration of German manufacturing industries and its determinants," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 40(1), pages 19-42, March.
    10. Adam B. Jaffe & Manuel Trajtenberg & Rebecca Henderson, 1993. "Geographic Localization of Knowledge Spillovers as Evidenced by Patent Citations," The Quarterly Journal of Economics, Oxford University Press, vol. 108(3), pages 577-598.
    11. Falck, Oliver & Heblich, Stephan & Kipar, Stefan, 2010. "Industrial innovation: Direct evidence from a cluster-oriented policy," Regional Science and Urban Economics, Elsevier, vol. 40(6), pages 574-582, November.
    12. Vuong, Quang H, 1989. "Likelihood Ratio Tests for Model Selection and Non-nested Hypotheses," Econometrica, Econometric Society, vol. 57(2), pages 307-333, March.
    13. Dirk Engel & Timo Mitze & Roberto Patuelli & Janina Reinkowski, 2013. "Does Cluster Policy Trigger R&D Activity? Evidence from German Biotech Contests," European Planning Studies, Taylor & Francis Journals, vol. 21(11), pages 1735-1759, November.
    14. Dirk Fornahl & Tom Broekel & Ron Boschma, 2011. "What drives patent performance of German biotech firms? The impact of R&D subsidies, knowledge networks and their location," Papers in Regional Science, Wiley Blackwell, vol. 90(2), pages 395-418, June.
    15. Ben R. Martin, 2016. "R&D policy instruments -- a critical review of what we do and don’t know," Industry and Innovation, Taylor & Francis Journals, vol. 23(2), pages 157-176, February.
    16. Uwe Cantner & Holger Graf, 2004. "Cooperation and specialization in German technology regions," Journal of Evolutionary Economics, Springer, vol. 14(5), pages 543-562, December.
    17. Baptista, Rui & Swann, Peter, 1998. "Do firms in clusters innovate more?," Research Policy, Elsevier, vol. 27(5), pages 525-540, September.
    18. Martin, Philippe & Mayer, Thierry & Mayneris, Florian, 2011. "Public support to clusters: A firm level study of French "Local Productive Systems"," Regional Science and Urban Economics, Elsevier, vol. 41(2), pages 108-123, March.
    19. M. S. Gertler & Y. M. Levitte, 2005. "Local Nodes in Global Networks: The Geography of Knowledge Flows in Biotechnology Innovation," Industry and Innovation, Taylor & Francis Journals, vol. 12(4), pages 487-507.
    20. Mitze, Timo & Strotebeck, Falk, 2017. "Modeling interregional research collaborations in German biotechnology using industry directory data: A quantitative social network analysis," MPRA Paper 83392, University Library of Munich, Germany.
    21. Tamás Krisztin & Manfred M. Fischer, 2015. "The Gravity Model for International Trade: Specification and Estimation Issues," Spatial Economic Analysis, Taylor & Francis Journals, vol. 10(4), pages 451-470, December.
    22. Escribano, Alvaro & Fosfuri, Andrea & Tribó, Josep A., 2009. "Managing external knowledge flows: The moderating role of absorptive capacity," Research Policy, Elsevier, vol. 38(1), pages 96-105, February.
    23. Engel, Dirk & Heneric, Oliver, 2005. "Biotechnologie-Gründungen im Ruhrgebiet: Eine vergleichende Analyse," RWI Materialien 21, RWI - Leibniz-Institut für Wirtschaftsforschung.
    24. Tom Broekel & Thomas Brenner, 2011. "Regional factors and innovativeness: an empirical analysis of four German industries," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 47(1), pages 169-194, August.
    25. Cilem Hazir & Corinne Autant-Bernard, 2014. "Determinants of cross-regional R&D collaboration: some empirical evidence from Europe in biotechnology," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 53(2), pages 369-393, September.
    26. Thomas Scherngell & Michael J. Barber, 2009. "Spatial interaction modelling of cross‐region R&D collaborations: empirical evidence from the 5th EU framework programme," Papers in Regional Science, Wiley Blackwell, vol. 88(3), pages 531-546, August.
    27. Stefan Töpfer & Uwe Cantner & Holger Graf, 2019. "Structural dynamics of innovation networks in German Leading-Edge Clusters," The Journal of Technology Transfer, Springer, vol. 44(6), pages 1816-1839, December.
    28. Breandán hUallacháin & Der-Shiuan Lee, 2014. "Urban centers and networks of co-invention in American biotechnology," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 52(3), pages 799-823, May.
    29. Stefano Breschi & Francesco Lissoni, 2009. "Mobility of skilled workers and co-invention networks: an anatomy of localized knowledge flows," Journal of Economic Geography, Oxford University Press, vol. 9(4), pages 439-468, July.
    30. Mario A. Maggioni & Mario Nosvelli & Teodora Erika Uberti, 2007. "Space versus networks in the geography of innovation: A European analysis," Papers in Regional Science, Wiley Blackwell, vol. 86(3), pages 471-493, August.
    31. Stéphane Maraut & Hélène Dernis & Colin Webb & Vincenzo Spiezia & Dominique Guellec, 2008. "The OECD REGPAT Database: A Presentation," OECD Science, Technology and Industry Working Papers 2008/2, OECD Publishing.
    32. Iris Wanzenb�ck & Thomas Scherngell & Rafael Lata, 2015. "Embeddedness of European Regions in European Union-Funded Research and Development (R&D) Networks: A Spatial Econometric Perspective," Regional Studies, Taylor & Francis Journals, vol. 49(10), pages 1685-1705, October.
    33. Ron Boschma, 2005. "Proximity and Innovation: A Critical Assessment," Regional Studies, Taylor & Francis Journals, vol. 39(1), pages 61-74.
    34. Iris Wanzenböck & Thomas Scherngell & Thomas Brenner, 2014. "Embeddedness of regions in European knowledge networks: a comparative analysis of inter-regional R&D collaborations, co-patents and co-publications," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 53(2), pages 337-368, September.
    35. Dohse, Dirk, 2000. "Technology policy and the regions -- the case of the BioRegio contest," Research Policy, Elsevier, vol. 29(9), pages 1111-1133, December.
    36. Dirk Dohse, 2007. "Cluster-Based Technology Policy—The German Experience," Industry and Innovation, Taylor & Francis Journals, vol. 14(1), pages 69-94.
    37. Michael Fritsch & Muhamed Kudic, 2016. "Preferential Attachment and Pattern Formation in R&D Networks - Plausible explanation or just a widespread myth?," Jena Economic Research Papers 2016-005, Friedrich-Schiller-University Jena.
    38. Balconi, Margherita & Breschi, Stefano & Lissoni, Francesco, 2004. "Networks of inventors and the role of academia: an exploration of Italian patent data," Research Policy, Elsevier, vol. 33(1), pages 127-145, January.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yindan Ye & Kevin De Moortel & Thomas Crispeels, 2020. "Network dynamics of Chinese university knowledge transfer," The Journal of Technology Transfer, Springer, vol. 45(4), pages 1228-1254, August.

    More about this item

    Keywords

    Biotechnology; Research network; Interregional collaboration; Regional innovation system; Network and cluster policy; Social network analysis;

    JEL classification:

    • C21 - Mathematical and Quantitative Methods - - Single Equation Models; Single Variables - - - Cross-Sectional Models; Spatial Models; Treatment Effect Models
    • L65 - Industrial Organization - - Industry Studies: Manufacturing - - - Chemicals; Rubber; Drugs; Biotechnology; Plastics
    • O38 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - Government Policy
    • R38 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - Real Estate Markets, Spatial Production Analysis, and Firm Location - - - Government Policy

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:techno:v:80-81:y:2019:i::p:40-53. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Haili He). General contact details of provider: http://www.sciencedirect.com/science/journal/01664972 .

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service hosted by the Research Division of the Federal Reserve Bank of St. Louis . RePEc uses bibliographic data supplied by the respective publishers.