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What Drives Regional Cooperative Behavior in German Biotechnology? Embedding Social Network Analysis in a Regression Framework

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  • Timo Mitze
  • Falk Strotebeck

Abstract

We analyse the determinants of network formation in German’s biotechnology sector combining elements from social network analysis (SNA) and a regression framework for count data. For the latter we adopt a regional innovation system perspective, we estimate the number of total and interregional R&D collaborations of local biotech actors in the year 2005 as a function of region’s innovation and economic context as well as a set of policy related variables. The inclusion of policy instruments in the regression approach allows us to answer the question to what extent R&D-based cluster policies such as the well-known BioRegio contest (BRC) shape the formation of the German biotech network. We use the region’s degree centrality, a standard measure in SNA, as outcome variable. Our results show that policy indicators such as the volume of public funding for collaborative R&D are positively correlated with the region’s total and interregional number of R&D cooperations. However, besides this direct funding effect no further advantages such as image effects etc. are found. Regarding the role of factors defining the regional innovation system, we observe that the number of biotech patent applications, the share of regional hightech start-ups and the population density are positively linked to the region’s degree centrality.

Suggested Citation

  • Timo Mitze & Falk Strotebeck, 2012. "What Drives Regional Cooperative Behavior in German Biotechnology? Embedding Social Network Analysis in a Regression Framework," ERSA conference papers ersa12p629, European Regional Science Association.
    • Handle: RePEc:wiw:wiwrsa:ersa12p629
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    1. Joachim Henkel & Stephen M. Maurer, 2010. "Network Effects in Biology R&D," American Economic Review, American Economic Association, vol. 100(2), pages 159-164, May.
    2. repec:zbw:rwimat:021 is not listed on IDEAS
    3. Roberto Patuelli & Norbert Schanne & Daniel A. Griffith & Peter Nijkamp, 2012. "Persistence Of Regional Unemployment: Application Of A Spatial Filtering Approach To Local Labor Markets In Germany," Journal of Regional Science, Wiley Blackwell, vol. 52(2), pages 300-323, May.
    4. Christoph Grimpe & Roberto Patuelli, 2011. "Regional knowledge production in nanomaterials: a spatial filtering approach," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 46(3), pages 519-541, June.
    5. Anne L.J. Ter Wal, 2011. "The Dynamics of the Inventor Network in German Biotechnology: Geographical Proximity versus Triadic Closure," Papers in Evolutionary Economic Geography (PEEG) 1102, Utrecht University, Department of Human Geography and Spatial Planning, Group Economic Geography, revised Jan 2011.
    6. Philip Cooke & Carla De Laurentis & Franz Tödtling & Michaela Trippl, 2007. "Regional Knowledge Economies," Books, Edward Elgar Publishing, number 3957.
    7. Vuong, Quang H, 1989. "Likelihood Ratio Tests for Model Selection and Non-nested Hypotheses," Econometrica, Econometric Society, vol. 57(2), pages 307-333, March.
    8. Elsie L. Echeverri-Carroll & William Brennan, 1999. "Are Innovation Networks Bounded by Proximity?," Advances in Spatial Science, in: Manfred M. Fischer & Luis Suarez-Villa & Michael Steiner (ed.), Innovation, Networks and Localities, chapter 3, pages 28-49, Springer.
    9. Cassi, Lorenzo & Plunket, Anne, 2010. "The determinants of co-inventor tie formation: proximity and network dynamics," MPRA Paper 27303, University Library of Munich, Germany.
    10. Dirk Fornahl & Tom Broekel & Ron Boschma, 2011. "What drives patent performance of German biotech firms? The impact of R&D subsidies, knowledge networks and their location," Papers in Regional Science, Wiley Blackwell, vol. 90(2), pages 395-418, June.
    11. Manfred M. Fischer & Luis Suarez-Villa & Michael Steiner (ed.), 1999. "Innovation, Networks and Localities," Advances in Spatial Science, Springer, number 978-3-642-58524-1, Fall.
    12. Uwe Cantner & Holger Graf, 2004. "Cooperation and specialization in German technology regions," Journal of Evolutionary Economics, Springer, vol. 14(5), pages 543-562, December.
    13. M. S. Gertler & Y. M. Levitte, 2005. "Local Nodes in Global Networks: The Geography of Knowledge Flows in Biotechnology Innovation," Industry and Innovation, Taylor & Francis Journals, vol. 12(4), pages 487-507.
    14. Oliver Falck & Stephan Heblich, 2007. "Modern Location Factors in Dynamic Regions," European Planning Studies, Taylor & Francis Journals, vol. 16(10), pages 1385-1403, May.
    15. Wagner, Alfred, 1891. "Marshall's Principles of Economics," History of Economic Thought Articles, McMaster University Archive for the History of Economic Thought, vol. 5, pages 319-338.
    16. repec:rim:rimwps:29-08 is not listed on IDEAS
    17. Daniel A. Griffith, 2003. "Spatial Autocorrelation and Spatial Filtering," Advances in Spatial Science, Springer, number 978-3-540-24806-4, Fall.
    18. Mario A. Maggioni & Mario Nosvelli & Teodora Erika Uberti, 2007. "Space versus networks in the geography of innovation: A European analysis," Papers in Regional Science, Wiley Blackwell, vol. 86(3), pages 471-493, August.
    19. Ron Boschma, 2005. "Proximity and Innovation: A Critical Assessment," Regional Studies, Taylor & Francis Journals, vol. 39(1), pages 61-74.
    20. Dohse, Dirk, 2000. "Technology policy and the regions -- the case of the BioRegio contest," Research Policy, Elsevier, vol. 29(9), pages 1111-1133, December.
    21. Daniel A. Griffith, 2000. "A linear regression solution to the spatial autocorrelation problem," Journal of Geographical Systems, Springer, vol. 2(2), pages 141-156, July.
    22. Anne Ter Wal & Ron Boschma, 2009. "Applying social network analysis in economic geography: framing some key analytic issues," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 43(3), pages 739-756, September.
    23. Stanley Wasserman & Philippa Pattison, 1996. "Logit models and logistic regressions for social networks: I. An introduction to Markov graphs andp," Psychometrika, Springer;The Psychometric Society, vol. 61(3), pages 401-425, September.
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