Genetic Markers as Instrumental Variables
The use of genetic markers as instrumental variables (IV) is receiving increasing attention from epidemiologists, economists, statisticians and social scientists. This paper examines the conditions that need to be met for genetic variants to be used as instruments. Although these have been discussed in the epidemiological, medical and statistical literature, they have not been well-defined in the economics and social science literature. The increasing availability of biomedical data however, makes understanding of these conditions crucial to the successful use of genotypes as instruments for modifiable risk factors. We combine the econometric IV literature with that from genetic epidemiology using a potential outcomes framework and review the IV conditions in the context of a social science application, examining the effect of child fat mass on academic performance.
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- von Hinke Kessler Scholder, S & Davey Smith, G & Lawlor, DA & Propper, C & Windmeijer, F, 2010.
"Child height, health and human capital: evidence using genetic markers,"
5947, Imperial College, London, Imperial College Business School.
- von Hinke Kessler Scholder, Stephanie & Davey Smith, George & Lawlor, Debbie A. & Propper, Carol & Windmeijer, Frank, 2013. "Child height, health and human capital: Evidence using genetic markers," European Economic Review, Elsevier, vol. 57(C), pages 1-22.
- Stephanie von Hinke Kessler Scholder & George Davey Smith & Debbie A. Lawlor & Carol Propper & Frank Windmeijer, 2010. "Child height, health and human capital: evidence using genetic markers," The Centre for Market and Public Organisation 10/245, Department of Economics, University of Bristol, UK.
- Barnard J. & Frangakis C.E. & Hill J.L. & Rubin D.B., 2003. "Principal Stratification Approach to Broken Randomized Experiments: A Case Study of School Choice Vouchers in New York City," Journal of the American Statistical Association, American Statistical Association, vol. 98, pages 299-323, January.
- Stephanie von Hinke Kessler Scholder & George Davey Smith & Debbie A. Lawlor & Carol Propper & Frank Windmeijer, 2011. "Mendelian randomization: the use of genes in instrumental variable analyses," Health Economics, John Wiley & Sons, Ltd., vol. 20(8), pages 893-896, 08.
- Frölich, Markus, 2002.
"Nonparametric IV Estimation of Local Average Treatment Effects with Covariates,"
IZA Discussion Papers
588, Institute for the Study of Labor (IZA).
- Frolich, Markus, 2007. "Nonparametric IV estimation of local average treatment effects with covariates," Journal of Econometrics, Elsevier, vol. 139(1), pages 35-75, July.
- Markus Froelich, 2002. "Nonparametric IV estimation of local average treatment effects with covariates," University of St. Gallen Department of Economics working paper series 2002 2002-19, Department of Economics, University of St. Gallen.
- Angrist, Joshua D & Graddy, Kathryn & Imbens, Guido W, 2000. "The Interpretation of Instrumental Variables Estimators in Simultaneous Equations Models with an Application to the Demand for Fish," Review of Economic Studies, Wiley Blackwell, vol. 67(3), pages 499-527, July.
- Imbens, Guido W & Angrist, Joshua D, 1994.
"Identification and Estimation of Local Average Treatment Effects,"
Econometric Society, vol. 62(2), pages 467-75, March.
- Joshua D. Angrist & Guido W. Imbens, 1995. "Identification and Estimation of Local Average Treatment Effects," NBER Technical Working Papers 0118, National Bureau of Economic Research, Inc.
- Edward C. Norton & Euna Han, 2008.
"Genetic information, obesity, and labor market outcomes,"
John Wiley & Sons, Ltd., vol. 17(9), pages 1089-1104.
- Edward C Norton & Euna Han, 2007. "Genetic Information, Obesity, and Labor Market Outcomes," Health, Econometrics and Data Group (HEDG) Working Papers 07/15, HEDG, c/o Department of Economics, University of York.
- John Cawley & Euna Han & Edward C. Norton, 2011. "The validity of genes related to neurotransmitters as instrumental variables," Health Economics, John Wiley & Sons, Ltd., vol. 20(8), pages 884-888, 08.
- Ding, Weili & Lehrer, Steven F. & Rosenquist, J.Niels & Audrain-McGovern, Janet, 2009. "The impact of poor health on academic performance: New evidence using genetic markers," Journal of Health Economics, Elsevier, vol. 28(3), pages 578-597, May.
- Fletcher, Jason M. & Lehrer, Steven F., 2011. "Genetic lotteries within families," Journal of Health Economics, Elsevier, vol. 30(4), pages 647-659, July.
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