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Milestone payments in alliances: The moderating effect of equity ownership and network centrality

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  • Hou, Wanrong
  • Levitas, Edward
  • Su, Taoyong
  • Wu, Sibin

Abstract

Previous research has produced ambiguous and incomplete conclusions on how milestone payments influence alliance performance. By integrating the contractual governance framework with insights from behavioral economics on intrinsic motivation, this research investigates how the structure of cash payments between research and development partners impacts alliance performance. Analyzing a dataset of 140 pharmaceutical and biopharmaceutical New Molecular Entities approved by the FDA from 1993 to 2016, we first demonstrate that increased milestone payments reduce alliance performance. We then show that this adverse effect is attenuated when the complement supplier holds equity in the technology producer. Lastly, we provide evidence that the network centrality of the complement supplier offsets the negative impact of milestone payments on performance. These findings bridge the gap between behavioral and contractual views, underscoring the importance of incorporating both perspectives in studying alliance outcomes.

Suggested Citation

  • Hou, Wanrong & Levitas, Edward & Su, Taoyong & Wu, Sibin, 2025. "Milestone payments in alliances: The moderating effect of equity ownership and network centrality," Technovation, Elsevier, vol. 142(C).
  • Handle: RePEc:eee:techno:v:142:y:2025:i:c:s0166497225000240
    DOI: 10.1016/j.technovation.2025.103192
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    as
    1. Holmstrom, Bengt, 1989. "Agency costs and innovation," Journal of Economic Behavior & Organization, Elsevier, vol. 12(3), pages 305-327, December.
    2. Bajari, Patrick & Tadelis, Steven, 2001. "Incentives versus Transaction Costs: A Theory of Procurement Contracts," RAND Journal of Economics, The RAND Corporation, vol. 32(3), pages 387-407, Autumn.
    3. repec:bla:jindec:v:46:y:1998:i:2:p:125-56 is not listed on IDEAS
    4. Thomas H. Noe & Michael J. Rebello & Milind M. Shrikhande, 2002. "Structuring International Cooperative Ventures," The Review of Financial Studies, Society for Financial Studies, vol. 15(4), pages 1251-1282.
    5. Samant, Shantala & Kim, Jongwook, 2023. "Best foot forward? The importance of contractual governance mechanisms for innovation from alliances," Technovation, Elsevier, vol. 127(C).
    6. Lerner, Josh & Shane, Hilary & Tsai, Alexander, 2003. "Do equity financing cycles matter? evidence from biotechnology alliances," Journal of Financial Economics, Elsevier, vol. 67(3), pages 411-446, March.
    7. Josh Lerner & Robert P. Merges, 1998. "The Control of Technology Alliances: An Empirical Analysis of the Biotechnology Industry," Journal of Industrial Economics, Wiley Blackwell, vol. 46(2), pages 125-156, June.
    8. Josh Lerner & Ulrike Malmendier, 2010. "Contractibility and the Design of Research Agreements," American Economic Review, American Economic Association, vol. 100(1), pages 214-246, March.
    9. Haim Faridian, Parisa, 2023. "Leading open innovation: The role of strategic entrepreneurial leadership in orchestration of value creation and capture in GitHub open source communities," Technovation, Elsevier, vol. 119(C).
    10. S. Trevis Certo & John R. Busenbark & Hyun‐soo Woo & Matthew Semadeni, 2016. "Sample selection bias and Heckman models in strategic management research," Strategic Management Journal, Wiley Blackwell, vol. 37(13), pages 2639-2657, December.
    11. Hall, Bronwyn H. & Lerner, Josh, 2010. "The Financing of R&D and Innovation," Handbook of the Economics of Innovation, in: Bronwyn H. Hall & Nathan Rosenberg (ed.), Handbook of the Economics of Innovation, edition 1, volume 1, chapter 0, pages 609-639, Elsevier.
    12. Oxley, Joanne E, 1997. "Appropriability Hazards and Governance in Strategic Alliances: A Transaction Cost Approach," The Journal of Law, Economics, and Organization, Oxford University Press, vol. 13(2), pages 387-409, October.
    13. Luis Diestre & Nandini Rajagopalan & Shantanu Dutta, 2015. "Constraints in acquiring and utilizing directors' experience: An empirical study of new-market entry in the pharmaceutical industry," Strategic Management Journal, Wiley Blackwell, vol. 36(3), pages 339-359, March.
    14. Rekha Krishnan & Inge Geyskens & Jan-Benedict E. M. Steenkamp, 2016. "The effectiveness of contractual and trust-based governance in strategic alliances under behavioral and environmental uncertainty," Strategic Management Journal, Wiley Blackwell, vol. 37(12), pages 2521-2542, December.
    15. Kreps, David M, 1997. "Intrinsic Motivation and Extrinsic Incentives," American Economic Review, American Economic Association, vol. 87(2), pages 359-364, May.
    16. Chen, Wenrui & Liu, Xinghe & Hong, Yun, 2023. "Two heads better than one? Strategic alliance and firms excess cash holdings," Finance Research Letters, Elsevier, vol. 52(C).
    17. Higgins, Matthew J., 2007. "The allocation of control rights in pharmaceutical alliances," Journal of Corporate Finance, Elsevier, vol. 13(1), pages 58-75, March.
    18. Bohnet, Iris & Frey, Bruno S. & Huck, Steffen, 2001. "More Order with Less Law: On Contract Enforcement, Trust, and Crowding," American Political Science Review, Cambridge University Press, vol. 95(1), pages 131-144, March.
    19. Luis Diestre & Nandini Rajagopalan, 2012. "Are all ‘sharks’ dangerous? new biotechnology ventures and partner selection in R&D alliances," Strategic Management Journal, Wiley Blackwell, vol. 33(10), pages 1115-1134, October.
    20. Joanne E. Oxley & Rachelle C. Sampson, 2004. "The scope and governance of international R&D alliances," Strategic Management Journal, Wiley Blackwell, vol. 25(8‐9), pages 723-749, August.
    21. Barrie R. Nault & Rajeev K. Tyagi, 2001. "Implementable Mechanisms to Coordinate Horizontal Alliances," Management Science, INFORMS, vol. 47(6), pages 787-799, June.
    22. Rebecca Henderson & Iain Cockburn, 1994. "Measuring Competence? Exploring Firm Effects in Pharmaceutical Research," Strategic Management Journal, Wiley Blackwell, vol. 15(S1), pages 63-84, December.
    23. Roland Bénabou & Jean Tirole, 2003. "Intrinsic and Extrinsic Motivation," The Review of Economic Studies, Review of Economic Studies Ltd, vol. 70(3), pages 489-520.
    24. Kloyer, Martin & Scholderer, Joachim, 2012. "Effective incomplete contracts and milestones in market-distant R&D collaboration," Research Policy, Elsevier, vol. 41(2), pages 346-357.
    25. Benjamin Barber & Luis Diestre, 2019. "Pushing for speed or scope? Pharmaceutical lobbying and Food and Drug Administration drug review," Strategic Management Journal, Wiley Blackwell, vol. 40(8), pages 1194-1218, August.
    26. Pisano, Gary P, 1989. "Using Equity Participation to Support Exchange: Evidence from the Biotechnology Industry," The Journal of Law, Economics, and Organization, Oxford University Press, vol. 5(1), pages 109-126, Spring.
    27. Dechenaux, Emmanuel & Thursby, Jerry & Thursby, Marie, 2011. "Inventor moral hazard in university licensing: The role of contracts," Research Policy, Elsevier, vol. 40(1), pages 94-104, February.
    28. Peter W. Roberts, 1999. "Product innovation, product–market competition and persistent profitability in the U.S. pharmaceutical industry," Strategic Management Journal, Wiley Blackwell, vol. 20(7), pages 655-670, July.
    29. Frank T. Rothaermel, 2001. "Incumbent's advantage through exploiting complementary assets via interfirm cooperation," Strategic Management Journal, Wiley Blackwell, vol. 22(6‐7), pages 687-699, June.
    30. David Dranove & David Meltzer, 1994. "Do Important Drugs Reach the Market Sooner?," RAND Journal of Economics, The RAND Corporation, vol. 25(3), pages 402-423, Autumn.
    31. Edward P. Lazear, 2000. "Economic Imperialism," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 115(1), pages 99-146.
    32. James Heckman, 2013. "Sample selection bias as a specification error," Applied Econometrics, Russian Presidential Academy of National Economy and Public Administration (RANEPA), vol. 31(3), pages 129-137.
    33. Frey, Bruno S., 1997. "On the relationship between intrinsic and extrinsic work motivation1," International Journal of Industrial Organization, Elsevier, vol. 15(4), pages 427-439, July.
    34. Jaffe, Adam B, 1986. "Technological Opportunity and Spillovers of R&D: Evidence from Firms' Patents, Profits, and Market Value," American Economic Review, American Economic Association, vol. 76(5), pages 984-1001, December.
    35. Barrie R. Nault & Rajeev K. Tyagi, 2001. "Erratum: Implementable Mechanisms to Coordinate Horizontal Alliances," Management Science, INFORMS, vol. 47(10), pages 1440-1440, October.
    36. Danzon, Patricia M. & Nicholson, Sean & Pereira, Nuno Sousa, 2005. "Productivity in pharmaceutical-biotechnology R&D: the role of experience and alliances," Journal of Health Economics, Elsevier, vol. 24(2), pages 317-339, March.
    37. Janet E. L. Bercovitz & Beverly B. Tyler, 2014. "Who I Am and How I Contract: The Effect of Contractors’ Roles on the Evolution of Contract Structure in University–Industry Research Agreements," Organization Science, INFORMS, vol. 25(6), pages 1840-1859, December.
    38. Jeffrey T. Macher & Christopher Boerner, 2012. "Technological development at the boundaries of the firm: a knowledge‐based examination in drug development," Strategic Management Journal, Wiley Blackwell, vol. 33(9), pages 1016-1036, September.
    39. Bart S. Vanneste & Phanish Puranam, 2010. "Repeated Interactions and Contractual Detail: Identifying the Learning Effect," Organization Science, INFORMS, vol. 21(1), pages 186-201, February.
    40. Sarah Kaplan, 2008. "Framing Contests: Strategy Making Under Uncertainty," Organization Science, INFORMS, vol. 19(5), pages 729-752, October.
    41. Williamson, Oliver E, 1993. "Calculativeness, Trust, and Economic Organization," Journal of Law and Economics, University of Chicago Press, vol. 36(1), pages 453-486, April.
    42. Mani, Sudha & Luo, Xueming, 2015. "Product alliances, alliance networks, and shareholder value: Evidence from the biopharmaceutical industry," International Journal of Research in Marketing, Elsevier, vol. 32(1), pages 9-22.
    43. David T. Robinson & Toby E. Stuart, 2007. "Network Effects in the Governance of Strategic Alliances," The Journal of Law, Economics, and Organization, Oxford University Press, vol. 23(1), pages 242-273, April.
    44. Joel S. Demski & David E.M. Sappington, 1991. "Resolving Double Moral Hazard Problems with Buyout Agreements," RAND Journal of Economics, The RAND Corporation, vol. 22(2), pages 232-240, Summer.
    45. Xu, Shichun & Fenik, Anton P. & Shaner, Matthew B., 2014. "Multilateral alliances and innovation output: The importance of equity and technological scope," Journal of Business Research, Elsevier, vol. 67(11), pages 2403-2410.
    46. Jongwook Kim, 2011. "Alliance governance and technological performance: some evidence from biotechnology alliances," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 20(4), pages 969-990, August.
    47. Lars Bo Jeppesen & Lars Frederiksen, 2006. "Why Do Users Contribute to Firm-Hosted User Communities? The Case of Computer-Controlled Music Instruments," Organization Science, INFORMS, vol. 17(1), pages 45-63, February.
    48. Ha Hoang & Frank T. Rothaermel, 2010. "Leveraging internal and external experience: exploration, exploitation, and R&D project performance," Strategic Management Journal, Wiley Blackwell, vol. 31(7), pages 734-758, July.
    49. Richard H. Thaler, 2016. "Behavioral Economics: Past, Present, and Future," American Economic Review, American Economic Association, vol. 106(7), pages 1577-1600, July.
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