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Growing fast or slow?: Understanding the variety of paths and the speed of early growth of entrepreneurial science-based firms

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  • Miozzo, Marcela
  • DiVito, Lori

Abstract

The paper explores the process of early growth of entrepreneurial science-based firms. Drawing on case studies of British and Dutch biopharmaceutical R&D firms, we conceptualize the speed of early growth of science-based firms as the time it takes for the assembly (or combined development) of three types of critical resources—a functionally-diverse management team, early fundraising and development of technology. The development of these resources is an unfolding and interrelated process, the causal direction of which is highly ambiguous. We show the variety of paths used by science-based firms to access and develop these critical resources. The picture that emerges is that the various combinations of what we call “assisted” and “unassisted” paths combine to influence the speed of firm growth. We show how a wide range of manifestations of technology development act as signaling devices to attract funding and management, affecting the speed of firm development. We also show how the variety of paths and the speed of development are influenced by the national institutional setting.

Suggested Citation

  • Miozzo, Marcela & DiVito, Lori, 2016. "Growing fast or slow?: Understanding the variety of paths and the speed of early growth of entrepreneurial science-based firms," Research Policy, Elsevier, vol. 45(5), pages 964-986.
    • Handle: RePEc:eee:respol:v:45:y:2016:i:5:p:964-986
    DOI: 10.1016/j.respol.2016.01.011
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    1. Einar Rasmussen & Simon Mosey & Mike Wright, 2011. "The Evolution of Entrepreneurial Competencies: A Longitudinal Study of University Spin‐Off Venture Emergence," Journal of Management Studies, Wiley Blackwell, vol. 48, pages 1314-1345, September.
    2. Gaston Heimeriks & Ron Boschma, 2014. "The path- and place-dependent nature of scientific knowledge production in biotech 1986–2008," Journal of Economic Geography, Oxford University Press, vol. 14(2), pages 339-364.
    3. Garnsey, Elizabeth, 1998. "A Theory of the Early Growth of the Firm," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 7(3), pages 523-556, September.
    4. Paul Almeida & Bruce Kogut, 1999. "Localization of Knowledge and the Mobility of Engineers in Regional Networks," Management Science, INFORMS, vol. 45(7), pages 905-917, July.
    5. Céline Druilhe & Elizabeth Garnsey, 2004. "Do Academic Spin-Outs Differ and Does it Matter?," The Journal of Technology Transfer, Springer, vol. 29(3_4), pages 269-285, August.
    6. Gry Agnete Alsos & Lars Kolvereid, 1998. "The Business Gestation Process of Novice, Serial, and Parallel Business Founders," Entrepreneurship Theory and Practice, , vol. 22(4), pages 101-114, July.
    7. Mangematin, Vincent & Lemarie, Stephane & Boissin, Jean-Pierre & Catherine, David & Corolleur, Frederic & Coronini, Roger & Trommetter, Michel, 2003. "Development of SMEs and heterogeneity of trajectories: the case of biotechnology in France," Research Policy, Elsevier, vol. 32(4), pages 621-638, April.
    8. DiVito, Lori, 2012. "Institutional entrepreneurship in constructing alternative paths: A comparison of biotech hybrids," Research Policy, Elsevier, vol. 41(5), pages 884-896.
    9. Murray, Fiona, 2004. "The role of academic inventors in entrepreneurial firms: sharing the laboratory life," Research Policy, Elsevier, vol. 33(4), pages 643-659, May.
    10. Sternitzke, Christian, 2010. "Knowledge sources, patent protection, and commercialization of pharmaceutical innovations," Research Policy, Elsevier, vol. 39(6), pages 810-821, July.
    11. Kolympiris, Christos & Kalaitzandonakes, Nicholas & Miller, Douglas, 2014. "Public funds and local biotechnology firm creation," Research Policy, Elsevier, vol. 43(1), pages 121-137.
    12. Müller, Kathrin, 2010. "Academic spin-off's transfer speed--Analyzing the time from leaving university to venture," Research Policy, Elsevier, vol. 39(2), pages 189-199, March.
    13. Annamaria Conti & Marie Thursby & Frank T. Rothaermel, 2013. "Show Me the Right Stuff: Signals for High‐Tech Startups," Journal of Economics & Management Strategy, Wiley Blackwell, vol. 22(2), pages 341-364, June.
    14. Yasemin Y. Kor & Joseph T. Mahoney, 2004. "Edith Penrose's (1959) Contributions to the Resource‐based View of Strategic Management," Journal of Management Studies, Wiley Blackwell, vol. 41(1), pages 183-191, January.
    15. Di Gregorio, Dante & Shane, Scott, 2003. "Why do some universities generate more start-ups than others?," Research Policy, Elsevier, vol. 32(2), pages 209-227, February.
    16. Casper, Steven & Matraves, Catherine, 2003. "Institutional frameworks and innovation in the German and UK pharmaceutical industry," Research Policy, Elsevier, vol. 32(10), pages 1865-1879, December.
    17. Haridimos Tsoukas & Robert Chia, 2002. "On Organizational Becoming: Rethinking Organizational Change," Organization Science, INFORMS, vol. 13(5), pages 567-582, October.
    18. Mustar, Philippe & Renault, Marie & Colombo, Massimo G. & Piva, Evila & Fontes, Margarida & Lockett, Andy & Wright, Mike & Clarysse, Bart & Moray, Nathalie, 2006. "Conceptualising the heterogeneity of research-based spin-offs: A multi-dimensional taxonomy," Research Policy, Elsevier, vol. 35(2), pages 289-308, March.
    19. Markman, Gideon D. & Gianiodis, Peter T. & Phan, Phillip H. & Balkin, David B., 2005. "Innovation speed: Transferring university technology to market," Research Policy, Elsevier, vol. 34(7), pages 1058-1075, September.
    20. Mirjam Knockaert & Deniz Ucbasaran & Mike Wright & Bart Clarysse, 2011. "The Relationship Between Knowledge Transfer, Top Management Team Composition, and Performance: The Case of Science–Based Entrepreneurial Firms," Entrepreneurship Theory and Practice, , vol. 35(4), pages 777-803, July.
    21. Michael M. Hopkins & Philippa A. Crane & Paul Nightingale & Charles Baden-Fuller, 2013. "Buying big into biotech: scale, financing, and the industrial dynamics of UK biotech, 1980--2009," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 22(4), pages 903-952, August.
    22. Hoenen, Sebastian & Kolympiris, Christos & Schoenmakers, Wilfred & Kalaitzandonakes, Nicholas, 2014. "The diminishing signaling value of patents between early rounds of venture capital financing," Research Policy, Elsevier, vol. 43(6), pages 956-989.
    23. Hoenig, Daniel & Henkel, Joachim, 2015. "Quality signals? The role of patents, alliances, and team experience in venture capital financing," Research Policy, Elsevier, vol. 44(5), pages 1049-1064.
    24. Luukkonen, Terttu, 2005. "Variability in organisational forms of biotechnology firms," Research Policy, Elsevier, vol. 34(4), pages 555-570, May.
    25. Marcela Miozzo & Lori DiVito & Panos Desyllas, 2011. "Cross-border acquisitions of science-based firms: Their effect on innovation in the acquired firm and the local science," DRUID Working Papers 11-17, DRUID, Copenhagen Business School, Department of Industrial Economics and Strategy/Aalborg University, Department of Business Studies.
    26. Hsu, David H., 2007. "Experienced entrepreneurial founders, organizational capital, and venture capital funding," Research Policy, Elsevier, vol. 36(5), pages 722-741, June.
    27. Casper, Steven, 2007. "How do technology clusters emerge and become sustainable?: Social network formation and inter-firm mobility within the San Diego biotechnology cluster," Research Policy, Elsevier, vol. 36(4), pages 438-455, May.
    28. Audretsch, David B. & Bönte, Werner & Mahagaonkar, Prashanth, 2012. "Financial signaling by innovative nascent ventures: The relevance of patents and prototypes," Research Policy, Elsevier, vol. 41(8), pages 1407-1421.
    29. Malerba, Franco & Orsenigo, Luigi, 1996. "Schumpeterian patterns of innovation are technology-specific," Research Policy, Elsevier, vol. 25(3), pages 451-478, May.
    30. Vincent Mangematin & Stéphane Lemarié & Jean-Pierre Boissin & David Catherine & Frédéric Corolleur & Roger Coronini & Michel Trommetter, 2003. "Development of SMEs and heterogeneity of trajectories: the case of biotechnology in France," Post-Print hal-00422563, HAL.
    31. Julia Porter Liebeskind & Amalya Lumerman Oliver & Lynne Zucker & Marilynn Brewer, 1996. "Social networks, Learning, and Flexibility: Sourcing Scientific Knowledge in New Biotechnology Firms," Organization Science, INFORMS, vol. 7(4), pages 428-443, August.
    32. Beckman, Christine M. & Burton, M. Diane & O'Reilly, Charles, 2007. "Early teams: The impact of team demography on VC financing and going public," Journal of Business Venturing, Elsevier, vol. 22(2), pages 147-173, March.
    33. Massimo Colombo & Philippe Mustar & Mike Wright, 2010. "Dynamics of Science-based entrepreneurship," The Journal of Technology Transfer, Springer, vol. 35(1), pages 1-15, February.
    34. Best, Michael H & Garnsey, Elizabeth, 1999. "Edith Penrose, 1914-1996," Economic Journal, Royal Economic Society, vol. 109(453), pages 187-201, February.
    35. Haeussler, Carolin & Harhoff, Dietmar & Mueller, Elisabeth, 2014. "How patenting informs VC investors – The case of biotechnology," Research Policy, Elsevier, vol. 43(8), pages 1286-1298.
    36. Daniel P. Forbes, 2005. "Managerial determinants of decision speed in new ventures," Strategic Management Journal, Wiley Blackwell, vol. 26(4), pages 355-366, April.
    37. Colin Crouch & Wolfgang Streeck & Robert Boyer & Bruno Amable & Peter A. Hall & Grégory Jackson, 2005. "Dialogue on ‘Institutional complementarity and political economy'," Université Paris1 Panthéon-Sorbonne (Post-Print and Working Papers) halshs-00310485, HAL.
    38. Baum, Joel A. C. & Silverman, Brian S., 2004. "Picking winners or building them? Alliance, intellectual, and human capital as selection criteria in venture financing and performance of biotechnology startups," Journal of Business Venturing, Elsevier, vol. 19(3), pages 411-436, May.
    39. Pitelis, Christos (ed.), 2002. "The Growth of the Firm: The Legacy of Edith Penrose," OUP Catalogue, Oxford University Press, number 9780199248520.
    40. Elizabeth Garnsey & Yuen Yoong Leong, 2008. "Combining Resource-Based and Evolutionary Theory to Explain the Genesis of Bio-networks," Industry and Innovation, Taylor & Francis Journals, vol. 15(6), pages 669-686.
    41. Mukti Khaire, 2010. "Young and No Money? Never Mind: The Material Impact of Social Resources on New Venture Growth," Organization Science, INFORMS, vol. 21(1), pages 168-185, February.
    42. G. N. von Tunzelmann, 1995. "Technology and Industrial Progress," Books, Edward Elgar Publishing, number 437.
    43. Hellmann, Thomas & Puri, Manju, 2000. "The Interaction between Product Market and Financing Strategy: The Role of Venture Capital," The Review of Financial Studies, Society for Financial Studies, vol. 13(4), pages 959-984.
    44. Clarysse, Bart & Moray, Nathalie, 2004. "A process study of entrepreneurial team formation: the case of a research-based spin-off," Journal of Business Venturing, Elsevier, vol. 19(1), pages 55-79, January.
    45. Zucker, Lynne G & Darby, Michael R & Brewer, Marilynn B, 1998. "Intellectual Human Capital and the Birth of U.S. Biotechnology Enterprises," American Economic Review, American Economic Association, vol. 88(1), pages 290-306, March.
    46. Andy Lockett, 2005. "Edith Penrose's legacy to the resource-based view," Managerial and Decision Economics, John Wiley & Sons, Ltd., vol. 26(2), pages 83-98.
    47. Julie M. Hite & William S. Hesterly, 2001. "The evolution of firm networks: from emergence to early growth of the firm," Strategic Management Journal, Wiley Blackwell, vol. 22(3), pages 275-286, March.
    48. Elaine Mosakowski, 1998. "Entrepreneurial Resources, Organizational Choices, and Competitive Outcomes," Organization Science, INFORMS, vol. 9(6), pages 625-643, December.
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    9. Zabara, Tatiana, 2019. "Evolution of entrepreneurial teams in technology-based new ventures," Other publications TiSEM cc09d065-3811-47b6-9c93-8, Tilburg University, School of Economics and Management.
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