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Knowledge sources, patent protection, and commercialization of pharmaceutical innovations

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  • Sternitzke, Christian

Abstract

This paper investigates different types of innovations (from radical to incremental) in the pharmaceutical industry by studying bibliometric data of drugs approved by the United States Food and Drug Administration (FDA), looking at time-to-market aspects, knowledge sources of these innovations, and protection strategies. Scientific knowledge stemming from the public sector is found to be important for all innovations. Nevertheless, radical innovations build on a higher degree on basic research, and they build on a significantly higher share of own prior scientific research than do incremental innovations. Furthermore, each drug is shown to be accompanied by, on average, about 19 journal publications and 23 additional patents. Additional patent filings peak when the commercialization of the drug is in reach. Firms do not differ among the various types of innovations regarding the amount of additional patent filings, but rather with the speed of filing these patents. Finally, this work contributes to the improvement of future econometric analyses that aim to link bibliometric indicators such as patent or publication counts to firm success.

Suggested Citation

  • Sternitzke, Christian, 2010. "Knowledge sources, patent protection, and commercialization of pharmaceutical innovations," Research Policy, Elsevier, vol. 39(6), pages 810-821, July.
  • Handle: RePEc:eee:respol:v:39:y:2010:i:6:p:810-821
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    References listed on IDEAS

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    1. Lang, Larry H P & Stulz, Rene M, 1994. "Tobin's q, Corporate Diversification, and Firm Performance," Journal of Political Economy, University of Chicago Press, vol. 102(6), pages 1248-1280, December.
    2. Rosenberg, Nathan & Nelson, Richard R., 1994. "American universities and technical advance in industry," Research Policy, Elsevier, vol. 23(3), pages 323-348, May.
    3. Mansfield, Edwin, 1998. "Academic research and industrial innovation: An update of empirical findings1," Research Policy, Elsevier, vol. 26(7-8), pages 773-776, April.
    4. Mansfield, Edwin, 1991. "Academic research and industrial innovation," Research Policy, Elsevier, vol. 20(1), pages 1-12, February.
    5. Dosi, Giovanni, 1988. "Sources, Procedures, and Microeconomic Effects of Innovation," Journal of Economic Literature, American Economic Association, vol. 26(3), pages 1120-1171, September.
    6. Dosi, Giovanni, 1993. "Technological paradigms and technological trajectories : A suggested interpretation of the determinants and directions of technical change," Research Policy, Elsevier, vol. 22(2), pages 102-103, April.
    7. Comanor, William S & Scherer, Frederic M, 1969. "Patent Statistics as a Measure of Technical Change," Journal of Political Economy, University of Chicago Press, vol. 77(3), pages 392-398, May/June.
    8. Zucker, Lynne G. & Darby, Michael R., 1997. "Present at the biotechnological revolution: transformation of technological identity for a large incumbent pharmaceutical firm," Research Policy, Elsevier, vol. 26(4-5), pages 429-446, December.
    9. Hirschey, Mark & Richardson, Vernon J., 2004. "Are scientific indicators of patent quality useful to investors?," Journal of Empirical Finance, Elsevier, vol. 11(1), pages 91-107, January.
    10. Hicks, Diana M. & Isard, Phoebe A. & Martin, Ben R., 1996. "A morphology of Japanese and European corporate research networks," Research Policy, Elsevier, vol. 25(3), pages 359-378, May.
    11. Nathan ROSENBERG, 2009. "Why do firms do basic research (with their own money)?," World Scientific Book Chapters,in: Studies On Science And The Innovation Process Selected Works of Nathan Rosenberg, chapter 11, pages 225-234 World Scientific Publishing Co. Pte. Ltd..
    12. Narin, Francis & Rozek, Richard P., 1988. "Bibliometric analysis of U.S. pharmaceutical industry research performance," Research Policy, Elsevier, vol. 17(3), pages 139-154, June.
    13. Henderson, Rebecca. & Cockburn, Iain., 1994. "Measuring competence? : exploring firm effects in pharmaceutical research," Working papers 3712-94., Massachusetts Institute of Technology (MIT), Sloan School of Management.
    14. Fama, Eugene F, 1970. "Efficient Capital Markets: A Review of Theory and Empirical Work," Journal of Finance, American Finance Association, vol. 25(2), pages 383-417, May.
    15. Achilladelis, Basil, 1993. "The dynamics of technological innovation: The sector of antibacterial medicines," Research Policy, Elsevier, vol. 22(4), pages 279-308, August.
    16. Adam B. Jaffe & Manuel Trajtenberg & Michael S. Fogarty, 2000. "The Meaning of Patent Citations: Report on the NBER/Case-Western Reserve Survey of Patentees," NBER Working Papers 7631, National Bureau of Economic Research, Inc.
    17. Wernerfelt, Birger & Montgomery, Cynthia A, 1988. "Tobin's q and the Importance of Focus in Firm Performance," American Economic Review, American Economic Association, vol. 78(1), pages 246-250, March.
    18. Gambardella, Alfonso, 1992. "Competitive advantages from in-house scientific research: The US pharmaceutical industry in the 1980s," Research Policy, Elsevier, vol. 21(5), pages 391-407, October.
    19. Chris Freeman & Luc Soete, 1997. "The Economics of Industrial Innovation, 3rd Edition," MIT Press Books, The MIT Press, edition 3, volume 1, number 0262061953, January.
    20. Tijssen, Robert J. W., 2004. "Is the commercialisation of scientific research affecting the production of public knowledge?: Global trends in the output of corporate research articles," Research Policy, Elsevier, vol. 33(5), pages 709-733, July.
    21. Birgitte Andersen, 1999. "The hunt for S-shaped growth paths in technological innovation: a patent study," Journal of Evolutionary Economics, Springer, vol. 9(4), pages 487-526.
    22. Cockburn, Iain M & Henderson, Rebecca M, 1998. "Absorptive Capacity, Coauthoring Behavior, and the Organization of Research in Drug Discovery," Journal of Industrial Economics, Wiley Blackwell, vol. 46(2), pages 157-182, June.
    23. Richard C. Levin & Alvin K. Klevorick & Richard R. Nelson & Sidney G. Winter, 1987. "Appropriating the Returns from Industrial Research and Development," Brookings Papers on Economic Activity, Economic Studies Program, The Brookings Institution, vol. 18(3, Specia), pages 783-832.
    24. Chaney, Paul K & Devinney, Timothy M & Winer, Russell S, 1991. "The Impact of New Product Introductions on the Market Value of Firms," The Journal of Business, University of Chicago Press, vol. 64(4), pages 573-610, October.
    25. Arundel, Anthony & Kabla, Isabelle, 1998. "What percentage of innovations are patented? empirical estimates for European firms," Research Policy, Elsevier, vol. 27(2), pages 127-141, June.
    26. Achilladelis, Basil & Schwarzkopf, Albert & Cines, Martin, 1990. "The dynamics of technological innovation: The case of the chemical industry," Research Policy, Elsevier, vol. 19(1), pages 1-34, February.
    27. Narin, Francis & Hamilton, Kimberly S. & Olivastro, Dominic, 1997. "The increasing linkage between U.S. technology and public science," Research Policy, Elsevier, vol. 26(3), pages 317-330, October.
    28. Fama, Eugene F, 1991. " Efficient Capital Markets: II," Journal of Finance, American Finance Association, vol. 46(5), pages 1575-1617, December.
    29. Achilladelis, Basil & Antonakis, Nicholas, 2001. "The dynamics of technological innovation: the case of the pharmaceutical industry," Research Policy, Elsevier, vol. 30(4), pages 535-588, April.
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    Cited by:

    1. Ugo Finardi, 2013. "The technological paradigm of Nanosciences and Technologies: a study of science-technology time and space relations," Economía: teoría y práctica, Universidad Autónoma Metropolitana, México, vol. 39(2), pages 11-29, Julio-Dic.
    2. Bhaven N. Sampat & Kenneth C. Shadlen, 2017. "Secondary Pharmaceutical Patenting: A Global Perspective," NBER Working Papers 23114, National Bureau of Economic Research, Inc.
    3. Shang, Qingyan & Poon, Jessie P.H. & Yue, Qingtang, 2012. "The role of regional knowledge spillovers on China's innovation," China Economic Review, Elsevier, vol. 23(4), pages 1164-1175.
    4. Sternitzke, Christian, 2013. "An exploratory analysis of patent fencing in pharmaceuticals: The case of PDE5 inhibitors," Research Policy, Elsevier, vol. 42(2), pages 542-551.
    5. Natália Barbosa & Ana Paula Faria & Vasco Eiriz, 2014. "Industry- and firm-specific factors of innovation novelty," Industrial and Corporate Change, Oxford University Press, vol. 23(3), pages 865-902.
    6. Miozzo, Marcela & DiVito, Lori, 2016. "Growing fast or slow?: Understanding the variety of paths and the speed of early growth of entrepreneurial science-based firms," Research Policy, Elsevier, vol. 45(5), pages 964-986.
    7. repec:spr:scient:v:105:y:2015:i:2:d:10.1007_s11192-015-1724-1 is not listed on IDEAS
    8. Anna Giunta & Filippo M. Pericoli & Eleonora Pierucci, 2016. "University–Industry collaboration in the biopharmaceuticals: the Italian case," The Journal of Technology Transfer, Springer, vol. 41(4), pages 818-840, August.
    9. repec:spr:scient:v:94:y:2013:i:1:d:10.1007_s11192-012-0785-7 is not listed on IDEAS
    10. repec:spr:scient:v:111:y:2017:i:3:d:10.1007_s11192-017-2357-3 is not listed on IDEAS
    11. Eleonora Pierucci, 2015. "University-industry linkages. Among italian regions: a supply-demand analysis," RIVISTA DI ECONOMIA E STATISTICA DEL TERRITORIO, FrancoAngeli Editore, vol. 2015(2), pages 5-33.
    12. Wagner, Stefan & Wakeman, Simon, 2016. "What do patent-based measures tell us about product commercialization? Evidence from the pharmaceutical industry," Research Policy, Elsevier, vol. 45(5), pages 1091-1102.
    13. Rahul RK Kapoor & Nicolas van Zeebroeck, 2016. "The laws of action and reaction: on determinants of patent disputes in European chemical and drug industries," iCite Working Papers WP 2016-019, ULB -- Universite Libre de Bruxelles.
    14. Sampat, Bhaven N. & Shadlen, Kenneth C., 2017. "Secondary pharmaceutical patenting: A global perspective," Research Policy, Elsevier, vol. 46(3), pages 693-707.
    15. Claudimar Pereira da Veiga & Cassia Rita Pereira da Veiga & Mônica Maier Giacomini & Heitor Takashi Kato & Jansen Maia Del Corso, 2015. "Evolution of Capabilities in the Discovery Cycle of an Innovation in the Pharmaceutical Market," International Review of Management and Marketing, Econjournals, vol. 5(3), pages 141-153.

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