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Knowledge sources, patent protection, and commercialization of pharmaceutical innovations

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  • Sternitzke, Christian

Abstract

This paper investigates different types of innovations (from radical to incremental) in the pharmaceutical industry by studying bibliometric data of drugs approved by the United States Food and Drug Administration (FDA), looking at time-to-market aspects, knowledge sources of these innovations, and protection strategies. Scientific knowledge stemming from the public sector is found to be important for all innovations. Nevertheless, radical innovations build on a higher degree on basic research, and they build on a significantly higher share of own prior scientific research than do incremental innovations. Furthermore, each drug is shown to be accompanied by, on average, about 19 journal publications and 23 additional patents. Additional patent filings peak when the commercialization of the drug is in reach. Firms do not differ among the various types of innovations regarding the amount of additional patent filings, but rather with the speed of filing these patents. Finally, this work contributes to the improvement of future econometric analyses that aim to link bibliometric indicators such as patent or publication counts to firm success.

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  • Sternitzke, Christian, 2010. "Knowledge sources, patent protection, and commercialization of pharmaceutical innovations," Research Policy, Elsevier, vol. 39(6), pages 810-821, July.
    • Handle: RePEc:eee:respol:v:39:y:2010:i:6:p:810-821
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    1. Jie Wu & Kathryn Rudie Harrigan & Siah Hwee Ang & Zefu Wu, 2019. "The impact of imitation strategy and R&D resources on incremental and radical innovation: evidence from Chinese manufacturing firms," The Journal of Technology Transfer, Springer, vol. 44(1), pages 210-230, February.
    2. Ugo Finardi, 2013. "The technological paradigm of Nanosciences and Technologies: a study of science-technology time and space relations," Economía: teoría y práctica, Universidad Autónoma Metropolitana, México, vol. 39(2), pages 11-29, Julio-Dic.
    3. Eleonora Pierucci, 2015. "University-industry linkages. Among italian regions: a supply-demand analysis," RIVISTA DI ECONOMIA E STATISTICA DEL TERRITORIO, FrancoAngeli Editore, vol. 2015(2), pages 5-33.
    4. Wagner, Stefan & Wakeman, Simon, 2016. "What do patent-based measures tell us about product commercialization? Evidence from the pharmaceutical industry," Research Policy, Elsevier, vol. 45(5), pages 1091-1102.
    5. Sampat, Bhaven N. & Shadlen, Kenneth C., 2017. "Secondary pharmaceutical patenting: A global perspective," Research Policy, Elsevier, vol. 46(3), pages 693-707.
    6. Gianluca Fabiano & Andrea Marcellusi & Giampiero Favato, 2020. "Public–private contribution to biopharmaceutical discoveries: a bibliometric analysis of biomedical research in UK," Scientometrics, Springer;Akadémiai Kiadó, vol. 124(1), pages 153-168, July.
    7. Rahul RK Kapoor & Nicolas van Zeebroeck, 2016. "The laws of action and reaction: on determinants of patent disputes in European chemical and drug industries," iCite Working Papers WP 2016-019, ULB -- Universite Libre de Bruxelles.
    8. Shang, Qingyan & Poon, Jessie P.H. & Yue, Qingtang, 2012. "The role of regional knowledge spillovers on China's innovation," China Economic Review, Elsevier, vol. 23(4), pages 1164-1175.
    9. Darlenis Herrera-Vallejera & Salvador Gorbea-Portal, 0. "Pharmacology and Pharmacy: research and innovation analysis," Scientometrics, Springer;Akadémiai Kiadó, vol. 0, pages 1-10.
    10. Chang, Ching-Wen & Yamanaka, Takayuki & Kano, Shingo, 2019. "An enforced loop-out knowledge flow facilitates industry competition: Learning from the pharmaceutical and genetically modified seed industries," Technovation, Elsevier, vol. 79(C), pages 11-24.
    11. Andrea Bastianin & Paolo Castelnovo & Massimo Florio & Anna Giunta, 2019. "Technological Learning and Innovation Gestation Lags at the Frontier of Science: from CERN Procurement to Patent," Papers 1905.09552, arXiv.org.
    12. Salandra, Rossella, 2018. "Knowledge dissemination in clinical trials: Exploring influences of institutional support and type of innovation on selective reporting," Research Policy, Elsevier, vol. 47(7), pages 1215-1228.
    13. Sternitzke, Christian, 2013. "An exploratory analysis of patent fencing in pharmaceuticals: The case of PDE5 inhibitors," Research Policy, Elsevier, vol. 42(2), pages 542-551.
    14. Natália Barbosa & Ana Paula Faria & Vasco Eiriz, 2014. "Industry- and firm-specific factors of innovation novelty," Industrial and Corporate Change, Oxford University Press, vol. 23(3), pages 865-902.
    15. Claudimar Pereira da Veiga & Cassia Rita Pereira da Veiga & Mônica Maier Giacomini & Heitor Takashi Kato & Jansen Maia Del Corso, 2015. "Evolution of Capabilities in the Discovery Cycle of an Innovation in the Pharmaceutical Market," International Review of Management and Marketing, Econjournals, vol. 5(3), pages 141-153.
    16. Miozzo, Marcela & DiVito, Lori, 2016. "Growing fast or slow?: Understanding the variety of paths and the speed of early growth of entrepreneurial science-based firms," Research Policy, Elsevier, vol. 45(5), pages 964-986.
    17. Roberto Camerani & Daniele Rotolo & Nicola Grassano, 2018. "Do firms publish? A multi-sectoral analysis," JRC Working Papers on Corporate R&D and Innovation 2018-05, Joint Research Centre (Seville site).
    18. Igor Rosa Dias Jesus & Helder Gomes Costa, 2015. "Interfaces between production engineering and the public affairs: evidences from bibliometric analysis," Scientometrics, Springer;Akadémiai Kiadó, vol. 105(2), pages 1183-1193, November.
    19. Anna Giunta & Filippo M. Pericoli & Eleonora Pierucci, 2016. "University–Industry collaboration in the biopharmaceuticals: the Italian case," The Journal of Technology Transfer, Springer, vol. 41(4), pages 818-840, August.
    20. Qingjun Zhao & Jiancheng Guan, 2013. "Love dynamics between science and technology: some evidences in nanoscience and nanotechnology," Scientometrics, Springer;Akadémiai Kiadó, vol. 94(1), pages 113-132, January.
    21. Du, Jian & Li, Peixin & Guo, Qianying & Tang, Xiaoli, 2019. "Measuring the knowledge translation and convergence in pharmaceutical innovation by funding-science-technology-innovation linkages analysis," Journal of Informetrics, Elsevier, vol. 13(1), pages 132-148.
    22. Guijie Zhang & Yuqiang Feng & Guang Yu & Luning Liu & Yanqiqi Hao, 2017. "Analyzing the time delay between scientific research and technology patents based on the citation distribution model," Scientometrics, Springer;Akadémiai Kiadó, vol. 111(3), pages 1287-1306, June.

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