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Network failure: Biotechnology firms, clusters and collaborations far from the world superclusters

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  • Gilding, Michael
  • Brennecke, Julia
  • Bunton, Vikki
  • Lusher, Dean
  • Molloy, Peter L.
  • Codoreanu, Alex

Abstract

This article traces the trajectory of biotechnology firms, clusters and collaborations in Australia between 2003 and 2014. Combining descriptive analyses, network visualizations and statistical modelling of longitudinal data collected from multiple sources, we investigate Australian firms’ ability to overcome the three challenges characterizing biotechnology: first, accessing new knowledge and intellectual property; second, raising early-stage funding for timely product development; and third, bringing products to market. Like biotechnology firms worldwide, Australian firms adopt a network approach to success, relying on different types of collaborative ties with diverse partners to access complementary resources and facilitate learning and innovation. The aspiration here is a virtuous cycle, where networks promote innovation and innovation promotes networks, as occurs in the world superclusters. In contrast, our analyses show that the collaborations of Australian biotechnology firms produce not so much a virtuous cycle, as a dead end. Specifically, local collaborations with public research organizations generate network effects in meeting the challenges of new knowledge and early-stage funding, but do not extend to the challenge of bringing products to market. We link this 'network failure' to the limitations of public research organizations as anchor tenants with the capability to catalyze collaborations with distant partner organizations directed towards commercialization, in particular giant multinational pharmaceutical corporations. Our study enriches the substantial literature on networked innovation, which is biased towards celebrating the benefits of networks and collaborations for innovation and performance, particularly in biotechnology.

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  • Gilding, Michael & Brennecke, Julia & Bunton, Vikki & Lusher, Dean & Molloy, Peter L. & Codoreanu, Alex, 2020. "Network failure: Biotechnology firms, clusters and collaborations far from the world superclusters," Research Policy, Elsevier, vol. 49(2).
  • Handle: RePEc:eee:respol:v:49:y:2020:i:2:s0048733319302203
    DOI: 10.1016/j.respol.2019.103902
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    as
    1. Guan, Jiancheng & Liu, Na, 2016. "Exploitative and exploratory innovations in knowledge network and collaboration network: A patent analysis in the technological field of nano-energy," Research Policy, Elsevier, vol. 45(1), pages 97-112.
    2. Joel A. C. Baum & Tony Calabrese & Brian S. Silverman, 2000. "Don't go it alone: alliance network composition and startups' performance in Canadian biotechnology," Strategic Management Journal, Wiley Blackwell, vol. 21(3), pages 267-294, March.
    3. Jeff S. Armstrong & Michael R. Darby & Lynne G. Zucker, 2003. "Commercializing knowledge: university science, knowledge capture and firm performance in biotechnology," Proceedings, Federal Reserve Bank of Dallas, issue Sep, pages 149-170.
    4. Manuel Trajtenberg, 1990. "A Penny for Your Quotes: Patent Citations and the Value of Innovations," RAND Journal of Economics, The RAND Corporation, vol. 21(1), pages 172-187, Spring.
    5. Clark, Tom S. & Linzer, Drew A., 2015. "Should I Use Fixed or Random Effects?," Political Science Research and Methods, Cambridge University Press, vol. 3(02), pages 399-408, May.
    6. Walter Powell & Kenneth Koput & James Bowie & Laurel Smith-Doerr, 2002. "The Spatial Clustering of Science and Capital: Accounting for Biotech Firm-Venture Capital Relationships," Regional Studies, Taylor & Francis Journals, vol. 36(3), pages 291-305.
    7. Productivity Commission, 2007. "Public Support for Science and Innovation," Research Reports, Productivity Commission, Government of Australia, number 24.
    8. Swann, Peter & Prevezer, Martha, 1996. "A comparison of the dynamics of industrial clustering in computing and biotechnology," Research Policy, Elsevier, vol. 25(7), pages 1139-1157, October.
    9. Gilsing, Victor & Nooteboom, Bart & Vanhaverbeke, Wim & Duysters, Geert & van den Oord, Ad, 2008. "Network embeddedness and the exploration of novel technologies: Technological distance, betweenness centrality and density," Research Policy, Elsevier, vol. 37(10), pages 1717-1731, December.
    10. repec:nct:journl:v:17:y:2009:i:8:p:1223-1241 is not listed on IDEAS
    11. Olivier Crevoisier & Hugues Jeannerat, "undated". "Territorial Knowledge Dynamics: From the Proximity Paradigm to Multi-location Milieus," GRET Journal Papers 08-09, GRET Group of Research in Territorial Economy, University of Neuchâtel.
    12. Julia Porter Liebeskind & Amalya Lumerman Oliver & Lynne Zucker & Marilynn Brewer, 1996. "Social networks, Learning, and Flexibility: Sourcing Scientific Knowledge in New Biotechnology Firms," Organization Science, INFORMS, vol. 7(4), pages 428-443, August.
    13. Michaela Trippl & Franz Todtling, 2007. "Developing Biotechnology Clusters in Non-high Technology Regions—The Case of Austria," Industry and Innovation, Taylor & Francis Journals, vol. 14(1), pages 47-67.
    14. M. S. Gertler & Y. M. Levitte, 2005. "Local Nodes in Global Networks: The Geography of Knowledge Flows in Biotechnology Innovation," Industry and Innovation, Taylor & Francis Journals, vol. 12(4), pages 487-507.
    15. Kevin Rees, 2005. "Interregional Collaboration And Innovation In Vancouver'S Emerging High‐Tech Cluster," Tijdschrift voor Economische en Sociale Geografie, Royal Dutch Geographical Society KNAG, vol. 96(3), pages 298-312, July.
    16. Al-Laham, Andreas & Souitaris, Vangelis, 2008. "Network embeddedness and new-venture internationalization: Analyzing international linkages in the German biotech industry," Journal of Business Venturing, Elsevier, vol. 23(5), pages 567-586, September.
    17. Jong, Simcha & Slavova, Kremena, 2014. "When publications lead to products: The open science conundrum in new product development," Research Policy, Elsevier, vol. 43(4), pages 645-654.
    18. Bell, Andrew & Jones, Kelvyn, 2015. "Explaining Fixed Effects: Random Effects Modeling of Time-Series Cross-Sectional and Panel Data," Political Science Research and Methods, Cambridge University Press, vol. 3(1), pages 133-153, January.
    19. Markus Simeth & Michele Cincera, 2016. "Corporate Science, Innovation, and Firm Value," Management Science, INFORMS, vol. 62(7), pages 1970-1981, July.
    20. Anna Butzin & Brigitta Widmaier, 2016. "Exploring Territorial Knowledge Dynamics through Innovation Biographies," Regional Studies, Taylor & Francis Journals, vol. 50(2), pages 220-232, February.
    21. Hopkins, Michael M. & Crane, Philippa & Nightingale, Paul & Baden-Fuller, Charles, 2019. "Moving from non-interventionism to industrial strategy: The roles of tentative and definitive governance in support of the UK biotech sector," Research Policy, Elsevier, vol. 48(5), pages 1113-1127.
    22. Miozzo, Marcela & DiVito, Lori, 2016. "Growing fast or slow?: Understanding the variety of paths and the speed of early growth of entrepreneurial science-based firms," Research Policy, Elsevier, vol. 45(5), pages 964-986.
    23. Margarida Fontes, 2005. "Distant networking: The knowledge acquisition strategies of 'out-cluster' biotechnology firms," European Planning Studies, Taylor & Francis Journals, vol. 13(6), pages 899-920, September.
    24. Olivier Crevoisier & Hugues Jeannerat, 2009. "Territorial Knowledge Dynamics: From the Proximity Paradigm to Multi-location Milieus," European Planning Studies, Taylor & Francis Journals, vol. 17(8), pages 1223-1241, August.
    25. Higgins, Matthew J. & Stephan, Paula E. & Thursby, Jerry G., 2011. "Conveying quality and value in emerging industries: Star scientists and the role of signals in biotechnology," Research Policy, Elsevier, vol. 40(4), pages 605-617, May.
    26. Dan Kaufmann & Dafna Schwartz & Amnon Frenkel & Daniel Shefer, 2003. "The Role of Location and Regional Networks for Biotechnology Firms in Israel," European Planning Studies, Taylor & Francis Journals, vol. 11(7), pages 823-840, October.
    27. Casper, Steven, 2007. "How do technology clusters emerge and become sustainable?: Social network formation and inter-firm mobility within the San Diego biotechnology cluster," Research Policy, Elsevier, vol. 36(4), pages 438-455, May.
    28. Philip Cooke, 2005. "Rational drug design, the knowledge value chain and bioscience megacentres," Cambridge Journal of Economics, Oxford University Press, vol. 29(3), pages 325-341, May.
    29. M�rio Vale & Lu�s Carvalho, 2013. "Knowledge Networks and Processes of Anchoring in Portuguese Biotechnology," Regional Studies, Taylor & Francis Journals, vol. 47(7), pages 1018-1033, July.
    30. Andrew A. Toole & Dirk Czarnitzki, 2010. "Commercializing Science: Is There a University "Brain Drain" from Academic Entrepreneurship?," Management Science, INFORMS, vol. 56(9), pages 1599-1614, September.
    31. McKelvey, Maureen & Alm, Hakan & Riccaboni, Massimo, 2003. "Does co-location matter for formal knowledge collaboration in the Swedish biotechnology-pharmaceutical sector?," Research Policy, Elsevier, vol. 32(3), pages 483-501, March.
    32. Bixia Xu, 2009. "Investment success and the value of investment opportunities: evidence from the biotech industry," Applied Financial Economics, Taylor & Francis Journals, vol. 19(7), pages 527-537.
    33. Francisco Polidoro & Matt Theeke, 2012. "Getting Competition Down to a Science: The Effects of Technological Competition on Firms' Scientific Publications," Organization Science, INFORMS, vol. 23(4), pages 1135-1153, August.
    34. Bertoni, Fabio & Tykvová, Tereza, 2015. "Does governmental venture capital spur invention and innovation? Evidence from young European biotech companies," Research Policy, Elsevier, vol. 44(4), pages 925-935.
    35. Clark, Tom S. & Linzer, Drew A., 2015. "Should I Use Fixed or Random Effects?," Political Science Research and Methods, Cambridge University Press, vol. 3(2), pages 399-408, May.
    36. Guido Capaldo & Margarida Fontes & Lorella Cannavacciuolo & Pierluigi Rippa & Cristina Sousa, 2015. "Networks Mobilized to Access Key Resources at Early Stages of Biotech Firms: A Comparative Analysis in Two Moderately Innovative Countries," European Planning Studies, Taylor & Francis Journals, vol. 23(7), pages 1381-1400, July.
    37. Sean Nicholson, 2005. "Biotech-Pharmaceutical Alliances as a Signal of Asset and Firm Quality," The Journal of Business, University of Chicago Press, vol. 78(4), pages 1433-1464, July.
    38. Michael M. Hopkins & Philippa A. Crane & Paul Nightingale & Charles Baden-Fuller, 2013. "Buying big into biotech: scale, financing, and the industrial dynamics of UK biotech, 1980--2009," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 22(4), pages 903-952, August.
    39. Douglas Cumming & Sofia Johan, 2009. "Pre-seed government venture capital funds," Journal of International Entrepreneurship, Springer, vol. 7(1), pages 26-56, March.
    40. Anna, Petrenko, 2016. "Мaркування готової продукції як складова частина інформаційного забезпечення маркетингової діяльності підприємств овочепродуктового підкомплексу," Agricultural and Resource Economics: International Scientific E-Journal, Agricultural and Resource Economics: International Scientific E-Journal, vol. 2(1), March.
    41. Douglas Cumming & Sofia Johan, 2016. "Venture’s economic impact in Australia," The Journal of Technology Transfer, Springer, vol. 41(1), pages 25-59, February.
    42. Dodgson, Mark & Hughes, Alan & Foster, John & Metcalfe, Stan, 2011. "Systems thinking, market failure, and the development of innovation policy: The case of Australia," Research Policy, Elsevier, vol. 40(9), pages 1145-1156.
    43. Aharonson, Barak S. & Baum, Joel A.C. & Plunket, Anne, 2008. "Inventive and uninventive clusters: The case of Canadian biotechnology," Research Policy, Elsevier, vol. 37(6-7), pages 1108-1131, July.
    44. Hopkins, Michael M. & Martin, Paul A. & Nightingale, Paul & Kraft, Alison & Mahdi, Surya, 2007. "The myth of the biotech revolution: An assessment of technological, clinical and organisational change," Research Policy, Elsevier, vol. 36(4), pages 566-589, May.
    45. Donna Marie DeCarolis & David L. Deeds, 1999. "The impact of stocks and flows of organizational knowledge on firm performance: an empirical investigation of the biotechnology industry," Strategic Management Journal, Wiley Blackwell, vol. 20(10), pages 953-968, October.
    46. Pavitt, Keith, 1998. "The social shaping of the national science base," Research Policy, Elsevier, vol. 27(8), pages 793-805, December.
    47. Ron Boschma, 2005. "Proximity and Innovation: A Critical Assessment," Regional Studies, Taylor & Francis Journals, vol. 39(1), pages 61-74.
    48. Stuart, Toby E. & Ozdemir, Salih Zeki & Ding, Waverly W., 2007. "Vertical alliance networks: The case of university-biotechnology-pharmaceutical alliance chains," Research Policy, Elsevier, vol. 36(4), pages 477-498, May.
    49. Gay, Brigitte & Dousset, Bernard, 2005. "Innovation and network structural dynamics: Study of the alliance network of a major sector of the biotechnology industry," Research Policy, Elsevier, vol. 34(10), pages 1457-1475, December.
    50. Alnuaimi, Tufool & Opsahl, Tore & George, Gerard, 2012. "Innovating in the periphery: The impact of local and foreign inventor mobility on the value of Indian patents," Research Policy, Elsevier, vol. 41(9), pages 1534-1543.
    51. Jason Owen-Smith & Walter W. Powell, 2004. "Knowledge Networks as Channels and Conduits: The Effects of Spillovers in the Boston Biotechnology Community," Organization Science, INFORMS, vol. 15(1), pages 5-21, February.
    52. Liang, Xinning & Liu, Anita M.M., 2018. "The evolution of government sponsored collaboration network and its impact on innovation: A bibliometric analysis in the Chinese solar PV sector," Research Policy, Elsevier, vol. 47(7), pages 1295-1308.
    53. Jane Marceau, 2007. "Bringing science to life in Australia: the need for a new approach in human health biotechnology policy," The Journal of Technology Transfer, Springer, vol. 32(4), pages 303-327, August.
    54. Li, Quan & Reuveny, Rafael, 2003. "Economic Globalization and Democracy: An Empirical Analysis," British Journal of Political Science, Cambridge University Press, vol. 33(1), pages 29-54, January.
    55. Sai Yayavaram & Manish K. Srivastava & MB Sarkar, 2018. "Role of search for domain knowledge and architectural knowledge in alliance partner selection," Strategic Management Journal, Wiley Blackwell, vol. 39(8), pages 2277-2302, August.
    56. Frank T. Rothaermel & Andrew M. Hess, 2007. "Building Dynamic Capabilities: Innovation Driven by Individual-, Firm-, and Network-Level Effects," Organization Science, INFORMS, vol. 18(6), pages 898-921, December.
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