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Bayesian econometric modelling of observational data for cost‐effectiveness analysis: establishing the value of negative pressure wound therapy in the healing of open surgical wounds

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  • Pedro Saramago
  • Karl Claxton
  • Nicky J. Welton
  • Marta Soares

Abstract

In the absence of evidence from randomized controlled trials on the relative effectiveness of treatments, cost‐effectiveness analyses increasingly use observational data instead. Treatment assignment is not, however, randomized, and naive estimates of the treatment effect may be biased. To deal with this bias, one may need to adjust for observed and unobserved confounders. In this work we explore and discuss the challenges of these adjustment strategies within a case‐study of negative pressure wound therapy (NPWT) for the treatment of surgical wounds healing by secondary intention. We could not demonstrate that existing uncontrolled confounding affects NPWT effectiveness, and thus there was no evidence that NPWT was cost effective compared with standard dressings for the treatment of surgical wounds healing by secondary intention.

Suggested Citation

  • Pedro Saramago & Karl Claxton & Nicky J. Welton & Marta Soares, 2020. "Bayesian econometric modelling of observational data for cost‐effectiveness analysis: establishing the value of negative pressure wound therapy in the healing of open surgical wounds," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 183(4), pages 1575-1593, October.
    • Handle: RePEc:bla:jorssa:v:183:y:2020:i:4:p:1575-1593
    DOI: 10.1111/rssa.12596
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    as
    1. Ryo Kato & Takahiro Hoshino, 2018. "Semiparametric Bayes Instrumental Variable Estimation with Many Weak Instruments," Discussion Paper Series DP2018-14, Research Institute for Economics & Business Administration, Kobe University.
    2. Kleibergen, Frank & Zivot, Eric, 2003. "Bayesian and classical approaches to instrumental variable regression," Journal of Econometrics, Elsevier, vol. 114(1), pages 29-72, May.
    3. Hansen, Lars Peter, 1982. "Large Sample Properties of Generalized Method of Moments Estimators," Econometrica, Econometric Society, vol. 50(4), pages 1029-1054, July.
    4. Chamberlain, Gary & Imbens, Guido, 1996. "Hierarchical Bayes Models with Many Instrumental Variables," Scholarly Articles 3221489, Harvard University Department of Economics.
    5. Manuel Wiesenfarth & Carlos Matías Hisgen & Thomas Kneib & Carmen Cadarso-Suarez, 2014. "Bayesian Nonparametric Instrumental Variables Regression Based on Penalized Splines and Dirichlet Process Mixtures," Journal of Business & Economic Statistics, Taylor & Francis Journals, vol. 32(3), pages 468-482, July.
    6. Theo S. Eicher & Alex Lenkoski & Adrian Raftery, 2009. "Bayesian Model Averaging and Endogeneity Under Model Uncertainty: An Application to Development Determinants," Working Papers UWEC-2009-19-FC, University of Washington, Department of Economics.
    7. David J. Spiegelhalter & Nicola G. Best & Bradley P. Carlin & Angelika Linde, 2014. "The deviance information criterion: 12 years on," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 76(3), pages 485-493, June.
    8. Maurice J. G. Bun & Teresa D. Harrison, 2019. "OLS and IV estimation of regression models including endogenous interaction terms," Econometric Reviews, Taylor & Francis Journals, vol. 38(7), pages 814-827, August.
    9. Chamberlain, Gary & Imbens, Guido W, 2003. "Nonparametric Applications of Bayesian Inference," Journal of Business & Economic Statistics, American Statistical Association, vol. 21(1), pages 12-18, January.
    10. Koop, Gary & Leon-Gonzalez, Roberto & Strachan, Rodney, 2012. "Bayesian model averaging in the instrumental variable regression model," Journal of Econometrics, Elsevier, vol. 171(2), pages 237-250.
    11. Hollenbach, Florian M. & Montgomery, Jacob M. & Crespo-Tenorio, Adriana, 2019. "Bayesian Versus Maximum Likelihood Estimation of Treatment Effects in Bivariate Probit Instrumental Variable Models," Political Science Research and Methods, Cambridge University Press, vol. 7(3), pages 651-659, July.
    12. M. Hashem Pesaran & Larry W. Taylor, 1999. "Diagnostics for IV Regressions," Oxford Bulletin of Economics and Statistics, Department of Economics, University of Oxford, vol. 61(2), pages 255-281, May.
    13. Hedibert F. Lopes & Nicholas G. Polson, 2014. "Bayesian Instrumental Variables: Priors and Likelihoods," Econometric Reviews, Taylor & Francis Journals, vol. 33(1-4), pages 100-121, June.
    14. Jack Hadley & Daniel Polsky & Jeanne S. Mandelblatt & Jean M. Mitchell & Jane C. Weeks & Qin Wang & Yi‐Ting Hwang & OPTIONS Research Team, 2003. "An exploratory instrumental variable analysis of the outcomes of localized breast cancer treatments in a medicare population," Health Economics, John Wiley & Sons, Ltd., vol. 12(3), pages 171-186, March.
    15. Aart Kraay, 2012. "Instrumental variables regressions with uncertain exclusion restrictions: a Bayesian approach," Journal of Applied Econometrics, John Wiley & Sons, Ltd., vol. 27(1), pages 108-128, January.
    16. Noémi Kreif & Richard Grieve & M. Zia Sadique, 2013. "Statistical Methods For Cost‐Effectiveness Analyses That Use Observational Data: A Critical Appraisal Tool And Review Of Current Practice," Health Economics, John Wiley & Sons, Ltd., vol. 22(4), pages 486-500, April.
    17. David J. Spiegelhalter & Nicola G. Best & Bradley P. Carlin & Angelika Van Der Linde, 2002. "Bayesian measures of model complexity and fit," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 64(4), pages 583-639, October.
    18. repec:bla:obuest:v:61:y:1999:i:2:p:255-81 is not listed on IDEAS
    19. Arnold Zellner & Tomohiro Ando & Nalan Baştük & Lennart Hoogerheide & Herman K. van Dijk, 2014. "Bayesian Analysis of Instrumental Variable Models: Acceptance-Rejection within Direct Monte Carlo," Econometric Reviews, Taylor & Francis Journals, vol. 33(1-4), pages 3-35, June.
    20. Imbens,Guido W. & Rubin,Donald B., 2015. "Causal Inference for Statistics, Social, and Biomedical Sciences," Cambridge Books, Cambridge University Press, number 9780521885881, June.
    21. Andrews,Donald W. K. & Stock,James H. (ed.), 2005. "Identification and Inference for Econometric Models," Cambridge Books, Cambridge University Press, number 9780521844413, June.
    22. John Mullahy, 1997. "Instrumental-Variable Estimation Of Count Data Models: Applications To Models Of Cigarette Smoking Behavior," The Review of Economics and Statistics, MIT Press, vol. 79(4), pages 586-593, November.
    23. Alex Lenkoski & Theo S. Eicher & Adrian E. Raftery, 2014. "Two-Stage Bayesian Model Averaging in Endogenous Variable Models," Econometric Reviews, Taylor & Francis Journals, vol. 33(1-4), pages 122-151, June.
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