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Creation of Biotech SMEs in France


  • C. Autant-Bernard


  • V. Mangematin


  • N. Massard



The paper examines the determinants of the creation of high tech SMEs at a regional level. Relations between the scientific and technical profile of a region, the size of the local market for biotech products and services, and economic development are explored in the French biotech industry during the 1990’s. Empirical analysis shows that a high level of scientific activity within a region is necessary to sustain a continuous flow of new business creation. The likelihood of firm creation depends on scientific and technological organizational factors like cooperation between academic and private organizations. Regional policies can have positive impact on firm creation, especially by promoting diversity and excellence in science. However, contrasting with the U.S. results, the size of the local market for biotech products and services matters in the industry development. Copyright Springer 2006

Suggested Citation

  • C. Autant-Bernard & V. Mangematin & N. Massard, 2006. "Creation of Biotech SMEs in France," Small Business Economics, Springer, vol. 26(2), pages 173-187, March.
  • Handle: RePEc:kap:sbusec:v:26:y:2006:i:2:p:173-187
    DOI: 10.1007/s11187-004-3578-4

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    References listed on IDEAS

    1. Paul Krugman & Anthony J. Venables, 1995. "Globalization and the Inequality of Nations," The Quarterly Journal of Economics, Oxford University Press, vol. 110(4), pages 857-880.
    2. Krugman, Paul, 1991. "Increasing Returns and Economic Geography," Journal of Political Economy, University of Chicago Press, vol. 99(3), pages 483-499, June.
    3. Lynne G. Zucker & Michael R. Darby & Maximo Torero, 2002. "Labor Mobility from Academe to Commerce," Journal of Labor Economics, University of Chicago Press, vol. 20(3), pages 629-660, July.
    4. repec:hhs:iuiwop:430 is not listed on IDEAS
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    Cited by:

    1. Calá, Carla Daniela, 2014. "Regional issues on firm entry and exit in argentina: core and peripheral regions," Nülan. Deposited Documents 2023, Universidad Nacional de Mar del Plata, Facultad de Ciencias Económicas y Sociales, Centro de Documentación.
    2. Elisabet Viladecans-Marsal & Josep-Maria Arauzo-Carod, 2012. "Can a knowledge-based cluster be created? The case of the Barcelona 22@ district," Papers in Regional Science, Wiley Blackwell, vol. 91(2), pages 377-400, June.
    3. Arauzo Carod, Josep Maria & Faggian, Alessandra & Mañé Vernet, Ferran, 2010. "Internal and External Determinants of Radical and incremental Innovation in SMEs: the case of Catalonia," Working Papers 2072/179605, Universitat Rovira i Virgili, Department of Economics.
    4. Josep-Maria Arauzo-Carod & Daniel Liviano-Solis & Miguel Manjón-Antolín, 2010. "Empirical Studies In Industrial Location: An Assessment Of Their Methods And Results," Journal of Regional Science, Wiley Blackwell, vol. 50(3), pages 685-711.
    5. Helen Lawton Smith & Saverio Romeo, 2016. "Regional Environments and Sector Developments: the Biotech Sector in Oxfordshire," Journal of the Knowledge Economy, Springer;Portland International Center for Management of Engineering and Technology (PICMET), vol. 7(4), pages 905-919, December.
    6. repec:spr:jknowl:v:8:y:2017:i:1:d:10.1007_s13132-015-0281-4 is not listed on IDEAS
    7. Cilem Hazir & Corinne Autant-Bernard, 2014. "Determinants of cross-regional R&D collaboration: some empirical evidence from Europe in biotechnology," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 53(2), pages 369-393, September.
    8. Elicia Maine & Daniel Shapiro & Aidan Vining, 2010. "The role of clustering in the growth of new technology-based firms," Small Business Economics, Springer, vol. 34(2), pages 127-146, February.
    9. Arauzo-Carod, Josep-Maria & Manjón-Antolín, Miguel & Martínez , Óscar, 2015. "The Relocation of R&D Establishments in France: An Empirical Analysis," INVESTIGACIONES REGIONALES - Journal of REGIONAL RESEARCH, Asociación Española de Ciencia Regional, issue 33, pages 97-119.
    10. João J. M. Ferreira & Cristina I. Fernandes & Mário L. Raposo & Roy Thurik & João R. Faria, 2016. "Entrepreneur location decisions across industries," International Entrepreneurship and Management Journal, Springer, vol. 12(4), pages 985-1006, December.
    11. Niklas Elert, 2014. "What determines entry? Evidence from Sweden," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 53(1), pages 55-92, August.
    12. Helen Lawton Smith & Sharmistha Bagchi-Sen & Laurel Edmunds, 2016. "Innovation capacity in the healthcare sector and historical anchors: examples from the UK, Switzerland and the US," The Journal of Technology Transfer, Springer, vol. 41(6), pages 1420-1439, December.
    13. Calá, Carla Daniela, 2009. "Spatial issues on firm demography: an analysis for Argentina," Nülan. Deposited Documents 1379, Universidad Nacional de Mar del Plata, Facultad de Ciencias Económicas y Sociales, Centro de Documentación.
    14. Frank Lasch & Frank Robert & Frédéric Roy, 2013. "Regional determinants of ICT new firm formation," Small Business Economics, Springer, vol. 40(3), pages 671-686, April.
    15. Liviano Solís, Daniel & Arauzo Carod, Josep Maria, 2011. "Industrial Location and Space: New Insights," Working Papers 2072/152137, Universitat Rovira i Virgili, Department of Economics.
    16. Josep-Maria Arauzo-Carod, 2008. "Industrial Location At A Local Level: Comments On The Territorial Level Of The Analysis," Tijdschrift voor Economische en Sociale Geografie, Royal Dutch Geographical Society KNAG, vol. 99(2), pages 193-208, April.

    More about this item


    biotechnology; creation; knowledge spillovers; SMEs; M130; Q130; L210; O30;

    JEL classification:

    • O30 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - General


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