IDEAS home Printed from https://ideas.repec.org/a/gam/jdataj/v7y2022i11p164-d976387.html
   My bibliography  Save this article

CoviRx: A User-Friendly Interface for Systematic Down-Selection of Repurposed Drug Candidates for COVID-19

Author

Listed:
  • Hardik A. Jain

    (Birla Institute of Technology and Science, Department of Electrical and Electronics Engineering, Pilani 333031, Rajasthan, India)

  • Vinti Agarwal

    (Birla Institute of Technology and Science, Department of Computer Science and Information Systems, Pilani 333031, Rajasthan, India)

  • Chaarvi Bansal

    (Birla Institute of Technology and Science, Department of Computer Science and Information Systems, Pilani 333031, Rajasthan, India
    School of Mathematics and Statistics, University of New South Wales, Sydney, NSW 1466, Australia)

  • Anupama Kumar

    (Commonwealth Scientific and Industrial Research Organisation, Land and Water, Waite Campus, Urrbrae, SA 5064, Australia)

  • Faheem

    (Birla Institute of Technology and Science, Department of Pharmacy, Pilani 333031, Rajasthan, India
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA)

  • Muzaffar-Ur-Rehman Mohammed

    (Birla Institute of Technology and Science, Department of Pharmacy, Pilani 333031, Rajasthan, India)

  • Sankaranarayanan Murugesan

    (Birla Institute of Technology and Science, Department of Pharmacy, Pilani 333031, Rajasthan, India)

  • Moana M. Simpson

    (Compounds Australia, Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD 4111, Australia)

  • Avinash V. Karpe

    (Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia
    Commonwealth Scientific and Industrial Research Organisation, Land and Water, Dutton Park, QLD 4102, Australia)

  • Rohitash Chandra

    (School of Mathematics and Statistics, University of New South Wales, Sydney, NSW 1466, Australia)

  • Christopher A. MacRaild

    (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3800, Australia)

  • Ian K. Styles

    (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3800, Australia)

  • Amanda L. Peterson

    (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3800, Australia
    Bio21 Institute, University of Melbourne, Parkville, VIC 3052, Australia)

  • Matthew A. Cooper

    (Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia)

  • Carl M. J. Kirkpatrick

    (Centre for Medicine Use and Safety, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia)

  • Rohan M. Shah

    (Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia)

  • Enzo A. Palombo

    (Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia)

  • Natalie L. Trevaskis

    (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3800, Australia)

  • Darren J. Creek

    (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3800, Australia)

  • Seshadri S. Vasan

    (Commonwealth Scientific and Industrial Research Organisation, Australian Centre for Disease Preparedness, Geelong, VIC 3220, Australia
    Department of Health, 189 Royal Street, East Perth, WA 6004, Australia
    Department of Health Sciences, University of York, York YO10 5DD, UK)

Abstract

Although various vaccines are now commercially available, they have not been able to stop the spread of COVID-19 infection completely. An excellent strategy to get safe, effective, and affordable COVID-19 treatments quickly is to repurpose drugs that are already approved for other diseases. The process of developing an accurate and standardized drug repurposing dataset requires considerable resources and expertise due to numerous commercially available drugs that could be potentially used to address the SARS-CoV-2 infection. To address this bottleneck, we created the CoviRx.org platform. CoviRx is a user-friendly interface that allows analysis and filtering of large quantities of data, which is onerous to curate manually for COVID-19 drug repurposing. Through CoviRx, the curated data have been made open source to help combat the ongoing pandemic and encourage users to submit their findings on the drugs they have evaluated, in a uniform format that can be validated and checked for integrity by authenticated volunteers. This article discusses the various features of CoviRx, its design principles, and how its functionality is independent of the data it displays. Thus, in the future, this platform can be extended to include any other disease beyond COVID-19.

Suggested Citation

  • Hardik A. Jain & Vinti Agarwal & Chaarvi Bansal & Anupama Kumar & Faheem & Muzaffar-Ur-Rehman Mohammed & Sankaranarayanan Murugesan & Moana M. Simpson & Avinash V. Karpe & Rohitash Chandra & Christoph, 2022. "CoviRx: A User-Friendly Interface for Systematic Down-Selection of Repurposed Drug Candidates for COVID-19," Data, MDPI, vol. 7(11), pages 1-19, November.
    • Handle: RePEc:gam:jdataj:v:7:y:2022:i:11:p:164-:d:976387
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/2306-5729/7/11/164/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/2306-5729/7/11/164/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Melitz, Jacques & Toubal, Farid, 2014. "Native language, spoken language, translation and trade," Journal of International Economics, Elsevier, vol. 93(2), pages 351-363.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Magnus Lodefalk & Fredrik Sjöholm & Aili Tang, 2022. "International trade and labour market integration of immigrants," The World Economy, Wiley Blackwell, vol. 45(6), pages 1650-1689, June.
    2. Lin, Wenlian & Cao, Jerry & Zhou, Sili & Li, Yong, 2024. "Political affinity, multilateralism, and foreign direct investment worldwide," Journal of International Financial Markets, Institutions and Money, Elsevier, vol. 94(C).
    3. Lo Turco, Alessia & Maggioni, Daniela, 2018. "Effects of Islamic religiosity on bilateral trust in trade: The case of Turkish exports," Journal of Comparative Economics, Elsevier, vol. 46(4), pages 947-965.
    4. Tamara Gurevich & Peter R. Herman & Farid Toubal & Y. Yotov, 2024. "The Domestic and International Common Language Database," Université Paris1 Panthéon-Sorbonne (Post-Print and Working Papers) hal-04682625, HAL.
    5. Victor Ginsburgh & Shlomo Weber, 2020. "The Economics of Language," Journal of Economic Literature, American Economic Association, vol. 58(2), pages 348-404, June.
    6. Victor Ginsburgh & Jacques Melitz & Farid Toubal, 2014. "Foreign Language Learning : An Econometric Analysis," Working Papers 2014-21, Center for Research in Economics and Statistics.
    7. Wessel, Jan, 2019. "Evaluating the transport-mode-specific trade effects of different transport infrastructure types," Transport Policy, Elsevier, vol. 78(C), pages 42-57.
    8. David M. Kemme & Bhavik Parikh & Tanja Steigner, 2017. "Tax Havens, Tax Evasion and Tax Information Exchange Agreements in the OECD," European Financial Management, European Financial Management Association, vol. 23(3), pages 519-542, June.
    9. Jing Yan, 2018. "Do Merger Laws Deter Cross‐Border Mergers and Acquisitions?," Australian Economic Papers, Wiley Blackwell, vol. 57(3), pages 376-393, September.
    10. Marchal, Léa & Naiditch, Claire, 2016. "A micro-funded theory of multilateral resistance to migration," Kiel Working Papers 2051, Kiel Institute for the World Economy (IfW Kiel).
    11. Joan Llull, 2018. "The Effect of Immigration on Wages: Exploiting Exogenous Variation at the National Level," Journal of Human Resources, University of Wisconsin Press, vol. 53(3), pages 608-662.
    12. Gianluca Orefice & Hillel Rapoport & Gianluca Santoni, 2021. "How Do Immigrants Promote Exports? Networks, Knowledge, Diversity," CESifo Working Paper Series 9288, CESifo.
    13. Karen Jackson & Oleksandr Shepotylo, 2021. "An examination of EU trade disintegration scenarios," The World Economy, Wiley Blackwell, vol. 44(1), pages 2-20, January.
    14. Paola Bertoli & Veronica Grembi & The Linh Bao Nguyen, 2023. "Birth outcomes in hard times among minority ethnic groups," Journal of Population Economics, Springer;European Society for Population Economics, vol. 36(1), pages 263-294, January.
    15. Liu, Tong & Lan, Bo, 2024. "On the conflict of natural resources abundance and export upgrading in upper-middle and high-income countries," Resources Policy, Elsevier, vol. 89(C).
    16. Xiwen Bai & Jesús Fernández-Villaverde & Yiliang Li & Francesco Zanetti, 2024. "The Causal Effects of Global Supply Chain Disruptions on Macroeconomic Outcomes: Evidence and Theory," Economics Series Working Papers 1033, University of Oxford, Department of Economics.
    17. Clémence Lenoir & Julien Martin & Isabelle Mejean, 2023. "Search Frictions in International Goods Markets," Journal of the European Economic Association, European Economic Association, vol. 21(1), pages 326-366.
    18. Daniel Hain & Sofia Johan & Daojuan Wang, 2016. "Determinants of Cross-Border Venture Capital Investments in Emerging and Developed Economies: The Effects of Relational and Institutional Trust," Journal of Business Ethics, Springer, vol. 138(4), pages 743-764, November.
    19. Krolikowski, Pawel M. & McCallum, Andrew H., 2021. "Goods-market frictions and international trade," Journal of International Economics, Elsevier, vol. 129(C).
    20. Arundhati Sinha Roy & Anwesha Aditya & Siddhartha Chattopadhyay & Sugata Marjit, 2024. "Comparative Advantage in the 24/7 Economy: Time-Zone Differences and Service Trade Flows," CESifo Working Paper Series 11290, CESifo.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jdataj:v:7:y:2022:i:11:p:164-:d:976387. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.