IDEAS home Printed from https://ideas.repec.org/a/eee/hepoli/v125y2021i5p553-567.html
   My bibliography  Save this article

COVID-19 vaccine challenges: What have we learned so far and what remains to be done?

Author

Listed:
  • Forman, Rebecca
  • Shah, Soleil
  • Jeurissen, Patrick
  • Jit, Mark
  • Mossialos, Elias

Abstract

Developing and distributing a safe and effective SARS-CoV-2 (COVID-19) vaccine has garnered immense global interest. Less than a year after COVID-19 was declared a pandemic, several vaccine candidates had received emergency use authorization across a range of countries. Despite this scientific breakthrough, the journey from vaccine discovery to global herd immunity against COVID-19 continues to present significant policy challenges that require a collaborative, global response. We offer a framework for understanding remaining and new policy challenges for successful global vaccine campaigns against COVID-19 as well as potential solutions to address them. Decision-makers must be aware of these challenges and strategize solutions that can be implemented at scale. These include challenges around maintaining R&D incentives, running clinical trials, authorizations, post-market surveillance, manufacturing and supply, global dissemination, allocation, uptake, and clinical system adaption. Alongside these challenges, financial and ethical concerns must also be addressed.

Suggested Citation

  • Forman, Rebecca & Shah, Soleil & Jeurissen, Patrick & Jit, Mark & Mossialos, Elias, 2021. "COVID-19 vaccine challenges: What have we learned so far and what remains to be done?," Health Policy, Elsevier, vol. 125(5), pages 553-567.
    • Handle: RePEc:eee:hepoli:v:125:y:2021:i:5:p:553-567
    DOI: 10.1016/j.healthpol.2021.03.013
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0168851021000853
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.healthpol.2021.03.013?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Aisling Irwin, 2021. "What it will take to vaccinate the world against COVID-19," Nature, Nature, vol. 592(7853), pages 176-178, April.
    2. Sebastian Neumann-Böhme & Nirosha Elsem Varghese & Iryna Sabat & Pedro Pita Barros & Werner Brouwer & Job Exel & Jonas Schreyögg & Tom Stargardt, 2020. "Once we have it, will we use it? A European survey on willingness to be vaccinated against COVID-19," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 21(7), pages 977-982, September.
    3. Brogan, David M. & Mossialos, Elias, 2016. "Systems, not pills: The options market for antibiotics seeks to rejuvenate the antibiotic pipeline," Social Science & Medicine, Elsevier, vol. 151(C), pages 167-172.
    4. Kieu C D Nguyen & Mario G Balzanelli & Pietro Distratis & Rita Lazzaro & Orazio Catucci & Angelo Cefalo & Davide Palazzo & Giuseppe D Angela & Felice Amatulli & C Isacco Gargiulo & Diego Tomassone & S, 2020. "Could Immunity Boosting Therapy help COVID-19 Patient?," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 30(1), pages 23149-23150, September.
    5. Forman, Rebecca & Atun, Rifat & McKee, Martin & Mossialos, Elias, 2020. "12 Lessons learned from the management of the coronavirus pandemic," Health Policy, Elsevier, vol. 124(6), pages 577-580.
    6. Ding, Wenzhi & Levine, Ross & Lin, Chen & Xie, Wensi, 2021. "Corporate immunity to the COVID-19 pandemic," Journal of Financial Economics, Elsevier, vol. 141(2), pages 802-830.
    7. Vincenzo Carrieri & Leonardo Madio & Francesco Principe, 2019. "Vaccine hesitancy and (fake) news: Quasi‐experimental evidence from Italy," Health Economics, John Wiley & Sons, Ltd., vol. 28(11), pages 1377-1382, November.
    8. Kanta Subbarao, 2020. "COVID-19 vaccines: time to talk about the uncertainties," Nature, Nature, vol. 586(7830), pages 475-475, October.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Fulian Yin & Meiqi Ji & Zhongliang Yang & Zhaoliang Wu & Xinyu Xia & Tongtong Xing & Yuwei She & Zhiwen Hu, 2022. "Exploring the determinants of global vaccination campaigns to combat COVID-19," Palgrave Communications, Palgrave Macmillan, vol. 9(1), pages 1-13, December.
    2. Lindsay S. Hunt & Erin E. Sullivan & Jordan Susa & Roger Chaufournier & Claudine Joseph & Russell S. Phillips & Kirsten Meisinger, 2023. "Using Rapid-Cycle Change to Improve COVID-19 Vaccination Strategy in Primary Care," IJERPH, MDPI, vol. 20(4), pages 1-9, February.
    3. Simon Munzert & Sebastian Ramirez-Ruiz & Başak Çalı & Lukas F. Stoetzer & Anita Gohdes & Will Lowe, 2022. "Prioritization preferences for COVID-19 vaccination are consistent across five countries," Palgrave Communications, Palgrave Macmillan, vol. 9(1), pages 1-10, December.
    4. Stephen A. Matlin & Alyna C. Smith & Jessica Merone & Michele LeVoy & Jalpa Shah & Frank Vanbiervliet & Stéphanie Vandentorren & Joanna Vearey & Luciano Saso, 2022. "The Challenge of Reaching Undocumented Migrants with COVID-19 Vaccination," IJERPH, MDPI, vol. 19(16), pages 1-25, August.
    5. Zéphirin Nganmeni & Roland Pongou & Bertrand Tchantcho & Jean‐Baptiste Tondji, 2022. "Vaccine and inclusion," Journal of Public Economic Theory, Association for Public Economic Theory, vol. 24(5), pages 1101-1123, October.
      • Zéphirin Nganmeni & Roland Pongou & Bertrand Tchantcho & Jean-Baptiste Tondji, 2022. "Vaccine and Inclusion," Working Papers 2202E Classification-C62,, University of Ottawa, Department of Economics.
    6. Refolo, Pietro & Bloemen, Bart & Corsano, Barbara & Grin, John & Gutierrez-Ibarluzea, Iñaki & Hofmann, Bjørn & Oortwijn, Wija & Sampietro-Colom, Laura & Sandman, Lars & van der Wilt, Gert Jan & Sacchi, 2022. "Prioritization of COVID-19 vaccination. The added value of the “VALIDATE” approach," Health Policy, Elsevier, vol. 126(8), pages 770-776.
    7. Ezgi Demir & Peter M. Bican, 2023. "Patents and Sustainable Medical Treatment in Developing Countries: Lessons from COVID-19 Vaccines," Sustainability, MDPI, vol. 15(4), pages 1-19, February.
    8. Rey, David & Hammad, Ahmed W. & Saberi, Meead, 2023. "Vaccine allocation policy optimization and budget sharing mechanism using reinforcement learning," Omega, Elsevier, vol. 115(C).
    9. Antonio Rosa de Sousa Neto & Ana Raquel Batista de Carvalho & Márcia Daiane Ferreira da Silva & Marly Marques Rêgo Neta & Inara Viviane de Oliveira Sena & Rosângela Nunes Almeida & Francidalma Soares , 2023. "Bibliometric Analysis of Global Scientific Production on COVID-19 and Vaccines," IJERPH, MDPI, vol. 20(6), pages 1-14, March.
    10. Valentin Marian Antohi & Romeo Victor Ionescu & Monica Laura Zlati & Cristian Mirica & Nicoleta Cristache, 2022. "Approaches to Health Efficiency across the European Space through the Lens of the Health Budget Effort," IJERPH, MDPI, vol. 19(5), pages 1-20, March.
    11. Wang, Binhua & Ping, Yuan, 2022. "A comparative analysis of COVID-19 vaccination certificates in 12 countries/regions around the world: Rationalising health policies for international travel and domestic social activities during the p," Health Policy, Elsevier, vol. 126(8), pages 755-762.
    12. Forman, Rebecca & Azzopardi-Muscat, Natasha & Kirkby, Victoria & Lessof, Suszy & Nathan, Naomi Limaro & Pastorino, Gabriele & Permanand, Govin & van Schalkwyk, May CI & Torbica, Aleksandra & Busse, Re, 2022. "Drawing light from the pandemic: Rethinking strategies for health policy and beyond," Health Policy, Elsevier, vol. 126(1), pages 1-6.
    13. Canoy, Nico A. & Robles, Augil Marie Q. & Roxas, Gilana Kim T., 2022. "Bodies-in-waiting as infrastructure: Assembling the Philippine Government's disciplinary quarantine response to COVID-19," Social Science & Medicine, Elsevier, vol. 294(C).
    14. Dayton,Julia M. & Edochie,Ifeanyi Nzegwu & Newhouse,David Locke & Cojocaru,Alexandru & Deudibe,Gildas Bopahbe & Kakietek,Jakub Jan & Kim,Yeon Soo & Montes,Jose, 2022. "COVID-19 Vaccine Hesitancy in 53 Developing Countries : Levels, Trends, and Reasons for Hesitancy," Policy Research Working Paper Series 10191, The World Bank.
    15. Laddawan Kaewkitipong & Charlie Chen & Peter Ractham, 2021. "Examining Factors Influencing COVID-19 Vaccine Tourism for International Tourists," Sustainability, MDPI, vol. 13(22), pages 1-18, November.
    16. Jiang, Peng & Klemeš, Jiří Jaromír & Fan, Yee Van & Fu, Xiuju & Tan, Raymond R. & You, Siming & Foley, Aoife M., 2021. "Energy, environmental, economic and social equity (4E) pressures of COVID-19 vaccination mismanagement: A global perspective," Energy, Elsevier, vol. 235(C).
    17. Ghio, Daniela & Bignami-Van Assche, Simona & Stilianakis, Nikolaos I., 2022. "Demographics of COVID-19 hospitalisations and related fatality risk patterns," Health Policy, Elsevier, vol. 126(10), pages 945-955.
    18. Milstein, Ricarda & Shatrov, Kosta & Schmutz, Lea Miranda & Blankart, Carl Rudolf, 2022. "How to pay primary care physicians for SARS-CoV-2 vaccinations: An analysis of 43 EU and OECD countries," Health Policy, Elsevier, vol. 126(6), pages 485-492.
    19. Sudhanshu Joshi & Manu Sharma, 2022. "A Literature Survey on Vaccine Supply Chain Management Amidst COVID-19: Literature Developments, Future Directions and Open Challenges for Public Health," World, MDPI, vol. 3(4), pages 1-28, October.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Sven Grüner & Felix Krüger, 2021. "The intention to be vaccinated against COVID-19: stated preferences before vaccines were available," Applied Economics Letters, Taylor & Francis Journals, vol. 28(21), pages 1847-1851, December.
    2. Kumar, Anand & Priya, Bhawna & Srivastava, Samir K., 2021. "Response to the COVID-19: Understanding implications of government lockdown policies," Journal of Policy Modeling, Elsevier, vol. 43(1), pages 76-94.
    3. Giulietti, Corrado & Vlassopoulos, Michael & Zenou, Yves, 2021. "When Reality Bites: Local Deaths and Vaccine Take-Up," GLO Discussion Paper Series 999, Global Labor Organization (GLO).
    4. Gu, Leilei & Liu, Zhongyang & Xu, Danyang, 2023. "The risk-mitigating role of corporate social responsibility in Chinese listed heavy-polluting companies: An extreme event experience perspective," Energy Economics, Elsevier, vol. 125(C).
    5. David Benjamin Billedeau & Jeffrey Wilson & Naima Samuel, 2022. "From Responsibility to Requirement: COVID, Cars, and the Future of Corporate Social Responsibility in Canada," Sustainability, MDPI, vol. 14(11), pages 1-16, May.
    6. Maneenop, Sakkakom & Kotcharin, Suntichai, 2020. "The impacts of COVID-19 on the global airline industry: An event study approach," Journal of Air Transport Management, Elsevier, vol. 89(C).
    7. Holden, Stein T. & Tione, Sarah & Tilahun, Mesfin & Katengeza, Samson, 2023. "Religion, beliefs, trust, and COVID vaccination behavior among rural people in Malawi?," CLTS Working Papers 4/23, Norwegian University of Life Sciences, Centre for Land Tenure Studies.
    8. Tine Buyl & Thomas Gehrig & Jonas Schreyögg & Andreas Wieland, 2022. "Resilience: A Critical Appraisal of the State of Research for Business and Society," Schmalenbach Journal of Business Research, Springer, vol. 74(4), pages 453-463, December.
    9. Refolo, Pietro & Bloemen, Bart & Corsano, Barbara & Grin, John & Gutierrez-Ibarluzea, Iñaki & Hofmann, Bjørn & Oortwijn, Wija & Sampietro-Colom, Laura & Sandman, Lars & van der Wilt, Gert Jan & Sacchi, 2022. "Prioritization of COVID-19 vaccination. The added value of the “VALIDATE” approach," Health Policy, Elsevier, vol. 126(8), pages 770-776.
    10. Rubio-Andrés, Mercedes & Ramos-González, Mª del Mar & Sastre-Castillo, Miguel Ángel & Gutiérrez-Broncano, Santiago, 2023. "Stakeholder pressure and innovation capacity of SMEs in the COVID-19 pandemic: Mediating and multigroup analysis," Technological Forecasting and Social Change, Elsevier, vol. 190(C).
    11. Ling, Aifan & Huang, Xinrui & Ling, Boya (Vivye), 2022. "Fund immunity to the COVID-19 pandemic: Evidence from Chinese equity funds," The North American Journal of Economics and Finance, Elsevier, vol. 63(C).
    12. Ferriani, Fabrizio, 2023. "Issuing bonds during the Covid-19 pandemic: Was there an ESG premium?," International Review of Financial Analysis, Elsevier, vol. 88(C).
    13. Sumin Hu & Qi Zhu & Xia Zhao & Ziyue Xu, 2023. "Digital Finance and Corporate Sustainability Performance: Promoting or Restricting? Evidence from China’s Listed Companies," Sustainability, MDPI, vol. 15(13), pages 1-16, June.
    14. Imen Khanchel & Naima Lassoued & Rym Gargoury, 2023. "CSR and firm value: is CSR valuable during the COVID 19 crisis in the French market?," Journal of Management & Governance, Springer;Accademia Italiana di Economia Aziendale (AIDEA), vol. 27(2), pages 575-601, June.
    15. Ștefan Cristian Gherghina & Daniel Ștefan Armeanu & Camelia Cătălina Joldeș, 2020. "Stock Market Reactions to COVID-19 Pandemic Outbreak: Quantitative Evidence from ARDL Bounds Tests and Granger Causality Analysis," IJERPH, MDPI, vol. 17(18), pages 1-35, September.
    16. Miquel-Flores, Ixart & Reghezza, Alessio & Buchetti, Bruno & Perdichizzi, Salvatore, 2024. "Greening the economy: how public-guaranteed loans influence firm-level resource allocation," Working Paper Series 2916, European Central Bank.
    17. Athira, A. & Ramesh, Vishnu K., 2023. "COVID-19 and corporate tax avoidance: International evidence," International Business Review, Elsevier, vol. 32(4).
    18. Debele, Efa Tadesse, 2021. "Social Resilience and Challenges of Covid-19," Technium Business and Management, Technium Science, vol. 1(1), pages 19-29.
    19. Ducret, Romain, 2021. "Investors' perception of business group membership during an economic crisis : Evidence from the COVID-19 pandemic," FSES Working Papers 524, Faculty of Economics and Social Sciences, University of Freiburg/Fribourg Switzerland.
    20. Felix Chopra & Ingar K. Haaland & Christopher Roth, 2021. "The Demand for Fact-Checking," CESifo Working Paper Series 9061, CESifo.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:hepoli:v:125:y:2021:i:5:p:553-567. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu or the person in charge (email available below). General contact details of provider: http://www.elsevier.com/locate/healthpol .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.