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Science-Technology Linkages in an Emerging Research Platform: The Case of Combinatorial Chemistry and Biology

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  • Stéphane Malo

    (University of Maastricht)

  • Aldo Geuna

    (University of Sussex)

Abstract

This article focuses on issues concerning science and technology relationships posed by the emergence of a new drug discovery method, namely, combinatorial chemistry and biology. We assess the scientific content of combinatorial chemistry and biology using citations in patents to scientific journals and compare this research platform with biotechnology. We also identify the institutional affiliation of all the authors of the cited papers, which leads us to an analysis of knowledge spillovers between the main participants in the research network. Finally, we examine the relevance of localisation in the process of knowledge exchange with regard to EU countries and the US. The result of the analysis provides evidence to support the view that the inventive capacity of a country is dependent upon the basic research which is carried out, especially in universities and public research centres located in the inventor's country.

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  • Stéphane Malo & Aldo Geuna, 2000. "Science-Technology Linkages in an Emerging Research Platform: The Case of Combinatorial Chemistry and Biology," Scientometrics, Springer;Akadémiai Kiadó, vol. 47(2), pages 303-321, February.
    • Handle: RePEc:spr:scient:v:47:y:2000:i:2:d:10.1023_a:1005643127551
    DOI: 10.1023/A:1005643127551
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    1. Adam B. Jaffe & Manuel Trajtenberg & Rebecca Henderson, 1993. "Geographic Localization of Knowledge Spillovers as Evidenced by Patent Citations," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 108(3), pages 577-598.
    2. Narin, Francis & Olivastro, Dominic, 1992. "Status report: Linkage between technology and science," Research Policy, Elsevier, vol. 21(3), pages 237-249, June.
    3. Jaffe, Adam B, 1989. "Real Effects of Academic Research," American Economic Review, American Economic Association, vol. 79(5), pages 957-970, December.
    4. Nathan ROSENBERG, 2009. "Why do firms do basic research (with their own money)?," World Scientific Book Chapters, in: Nathan Rosenberg (ed.), Studies On Science And The Innovation Process Selected Works of Nathan Rosenberg, chapter 11, pages 225-234, World Scientific Publishing Co. Pte. Ltd..
    5. Thomke, Stefan & von Hippel, Eric & Franke, Roland, 1998. "Modes of experimentation: an innovation process--and competitive--variable," Research Policy, Elsevier, vol. 27(3), pages 315-332, July.
    6. Surya Mahdi & Keith Pavitt, 1997. "Key National Factors in the Emergence of Computational Chemistry Firms," International Journal of Innovation Management (ijim), World Scientific Publishing Co. Pte. Ltd., vol. 1(04), pages 355-386.
    7. Narin, Francis & Hamilton, Kimberly S. & Olivastro, Dominic, 1997. "The increasing linkage between U.S. technology and public science," Research Policy, Elsevier, vol. 26(3), pages 317-330, October.
    8. Collins, Peter & Wyatt, Suzanne, 1988. "Citations in patents to the basic research literature," Research Policy, Elsevier, vol. 17(2), pages 65-74, April.
    9. van Vianen, B. G. & Moed, H. F. & van Raan, A. F. J., 1990. "An exploration of the science base of recent technology," Research Policy, Elsevier, vol. 19(1), pages 61-81, February.
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    Cited by:

    1. Arundel, Anthony & Bordoy, Catalina, 2008. "Developing internationally comparable indicators for the commercialization of publicly-funded research," MERIT Working Papers 2008-075, United Nations University - Maastricht Economic and Social Research Institute on Innovation and Technology (MERIT).
    2. Meyer, Martin, 2006. "Are patenting scientists the better scholars?: An exploratory comparison of inventor-authors with their non-inventing peers in nano-science and technology," Research Policy, Elsevier, vol. 35(10), pages 1646-1662, December.
    3. Dan Marsh, 2000. "Fostering Innovation in a Small Open Economy: The Case of the New Zealand Biotechnology Sector," Working Papers in Economics 00/01, University of Waikato.
    4. Hyun Woo Park & Jay Kang, 2009. "Patterns of scientific and technological knowledge flows based on scientific papers and patents," Scientometrics, Springer;Akadémiai Kiadó, vol. 81(3), pages 811-820, December.
    5. Hector Gonzalo Ordóñez‐Matamoros & Susan E. Cozzens & Margarita Garcia, 2010. "International Co‐Authorship and Research Team Performance in Colombia," Review of Policy Research, Policy Studies Organization, vol. 27(4), pages 415-431, July.
    6. Ugo Rizzo & Nicolò Barbieri & Laura Ramaciotti & Demian Iannantuono, 2020. "The division of labour between academia and industry for the generation of radical inventions," The Journal of Technology Transfer, Springer, vol. 45(2), pages 393-413, April.
    7. Fassio, Claudio & Geuna, Aldo & Rossi, Federica, 2014. "The Contribution of Academic Knowledge to the Value of Industry Inventions: Micro level evidence from patent inventors," Department of Economics and Statistics Cognetti de Martiis LEI & BRICK - Laboratory of Economics of Innovation "Franco Momigliano", Bureau of Research in Innovation, Complexity and Knowledge, Collegio 201408, University of Turin.
    8. Malo, Stéphane, 2009. "The contribution of (not so) public research to commercial innovations in the field of combinatorial chemistry," Research Policy, Elsevier, vol. 38(6), pages 957-970, July.
    9. Stefano Brusoni & Paola Criscuolo & Aldo Geuna, 2005. "The knowledge bases of the world's largest pharmaceutical groups: what do patent citations to non-patent literature reveal?," Economics of Innovation and New Technology, Taylor & Francis Journals, vol. 14(5), pages 395-415.
    10. Lili Wang & Zexia Li, 2021. "Knowledge flows from public science to industrial technologies," The Journal of Technology Transfer, Springer, vol. 46(4), pages 1232-1255, August.
    11. Tijssen, Robert J. W., 2002. "Science dependence of technologies: evidence from inventions and their inventors," Research Policy, Elsevier, vol. 31(4), pages 509-526, May.
    12. Robert Tomaszewski, 2017. "Citations to chemical resources in scholarly articles: CRC Handbook of Chemistry and Physics and The Merck Index," Scientometrics, Springer;Akadémiai Kiadó, vol. 112(3), pages 1865-1879, September.
    13. Anthony Arundel & Aldo Geuna, 2001. "Does Proximity Matter for Knowledge Transfer from Public Institutes and Universities to Firms?," SPRU Working Paper Series 73, SPRU - Science Policy Research Unit, University of Sussex Business School.
    14. Brusoni, Stefano & Geuna, Aldo, 2003. "An international comparison of sectoral knowledge bases: persistence and integration in the pharmaceutical industry," Research Policy, Elsevier, vol. 32(10), pages 1897-1912, December.
    15. Larsen, Maria Theresa, 2011. "The implications of academic enterprise for public science: An overview of the empirical evidence," Research Policy, Elsevier, vol. 40(1), pages 6-19, February.
    16. Dan Marsh, 2004. "Biotechnology in New Zealand," Working Papers in Economics 04/01, University of Waikato.
    17. John Hagedoorn & Boris Lokshin & Stéphane Malo, 2018. "Alliances and the innovation performance of corporate and public research spin-off firms," Small Business Economics, Springer, vol. 50(4), pages 763-781, April.

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