The Knowledge Bases of the World's Largest Pharmaceuticals Groups: what do Patent Citations to Non-Patent Literature Reveal?
This paper examines the knowledge bases of the world's largest pharmaceuticals groups by sales. It puts forward the concepts of knowledge breadth and depth as the relevant dimensions along which knowledge bases can be mapped. Breadth is studied by analysing the evolution of specialisation by scientific field over time. It hints at the widening range of bodies of scientific and technological knowledge relevant to firms' innovative activities. Depth (or integration) is studied by analysing the evolution of specialisation across different typologies of research. It hints at the complex, non-linear interdependencies that link the scientific and technological domains. We develop the analyses on the strength of an original database of 33,127 EPO patents, and of 41,931 'non patent document' citations (of which 19,494 were identified as scientific articles included in the ISI databases). The groups studied seem to have incrementally increased the breadth of their knowledge bases, moving toward the fields proper of the new bio-pharmaceutical research trajectory. At the same time, some of the groups studied exhibit remarkable depth in knowledge specialisation in particular fields such as biotechnology, biochemical research and neurosciences. Finally, this paper also provides a first methodological test of possible problems deriving from the use of 'unidentified' patent citations (i.e. added by the examiners together with those proposed by the inventor). We compare a random sample of these citations with a sample of citations explicitly added by the original inventor, and compare the results in terms of scientific specialisations.
|Date of creation:||01 Jun 2003|
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- Prencipe, Andrea, 1997. "Technological competencies and product's evolutionary dynamics a case study from the aero-engine industry," Research Policy, Elsevier, vol. 25(8), pages 1261-1276, January.
- Malo Stéphane & Geuna Aldo, 1999. "Science-Technology Linkages in an Emerging Research Platform: The case of Combinatorial Chemistry and Biology," Research Memorandum 020, Maastricht University, Maastricht Economic Research Institute on Innovation and Technology (MERIT).
- Stefano Brusoni & Paola Criscuolo & Aldo Geuna, 2005.
"The knowledge bases of the world's largest pharmaceutical groups: what do patent citations to non-patent literature reveal?,"
Economics of Innovation and New Technology,
Taylor & Francis Journals, vol. 14(5), pages 395-415.
- Stefano Brusoni & Paola Criscuolo & Aldo Geuna, 2003. "The Knowledge Bases of the World's Largest Pharmaceuticals Groups: what do Patent Citations to Non-Patent Literature Reveal?," SPRU Working Paper Series 90, SPRU - Science and Technology Policy Research, University of Sussex.
- Henderson, Rebecca., 1994. "The evolution of integrative capability : innovation in cardiovascular drug discovery," Working papers 3711-94., Massachusetts Institute of Technology (MIT), Sloan School of Management.
- Henderson, Rebecca. & Cockburn, Iain., 1994. "Measuring competence? : exploring firm effects in pharmaceutical research," Working papers 3712-94., Massachusetts Institute of Technology (MIT), Sloan School of Management.
- Rebecca Henderson & Iain Cockburn, 1996.
"Scale, Scope, and Spillovers: The Determinants of Research Productivity in Drug Discovery,"
RAND Journal of Economics,
The RAND Corporation, vol. 27(1), pages 32-59, Spring.
- Rebecca Henderson & Iain Cockburn, . "Scale, Scope and Spillovers: The Determinants of Research Productivity in Drug Discovery," Working Papers ec25/94, Department of Economics, University of Lancaster.
- Richard R. Nelson, 2003.
"On the Uneven Evolution of Human Know-How,"
LEM Papers Series
2003/25, Laboratory of Economics and Management (LEM), Sant'Anna School of Advanced Studies, Pisa, Italy.
- Meyer, Martin, 2000. "Does science push technology? Patents citing scientific literature," Research Policy, Elsevier, vol. 29(3), pages 409-434, March.
- Gambardella,Alfonso, 1995. "Science and Innovation," Cambridge Books, Cambridge University Press, number 9780521451185, june. pag.
- Soete, Luc, 1987. "The impact of technological innovation on international trade patterns: The evidence reconsidered," Research Policy, Elsevier, vol. 16(2-4), pages 101-130, August.
- Narin, Francis & Hamilton, Kimberly S. & Olivastro, Dominic, 1997. "The increasing linkage between U.S. technology and public science," Research Policy, Elsevier, vol. 26(3), pages 317-330, October.
- Arora, Ashish & Gambardella, Alfonso, 1994. "The changing technology of technological change: general and abstract knowledge and the division of innovative labour," Research Policy, Elsevier, vol. 23(5), pages 523-532, September.
- Miller, Roger, et al, 1995. "Innovation in Complex Systems Industries: The Case of Flight Simulation," Industrial and Corporate Change, Oxford University Press, vol. 4(2), pages 363-400.
- Adam B. Jaffe, 1986.
"Technological Opportunity and Spillovers of R&D: Evidence from Firms' Patents, Profits and Market Value,"
NBER Working Papers
1815, National Bureau of Economic Research, Inc.
- Jaffe, Adam B, 1986. "Technological Opportunity and Spillovers of R&D: Evidence from Firms' Patents, Profits, and Market Value," American Economic Review, American Economic Association, vol. 76(5), pages 984-1001, December.
- Wang, Q. & von Tunzelmann, N., 2000. "Complexity and the functions of the firm: breadth and depth," Research Policy, Elsevier, vol. 29(7-8), pages 805-818, August.
- Narin, Francis & Rozek, Richard P., 1988. "Bibliometric analysis of U.S. pharmaceutical industry research performance," Research Policy, Elsevier, vol. 17(3), pages 139-154, June.
- Tijssen, Robert J. W., 2002. "Science dependence of technologies: evidence from inventions and their inventors," Research Policy, Elsevier, vol. 31(4), pages 509-526, May.
- Prencipe, Andrea, 2000. "Breadth and depth of technological capabilities in CoPS: the case of the aircraft engine control system," Research Policy, Elsevier, vol. 29(7-8), pages 895-911, August.
- Manuel Trajtenberg & Rebecca Henderson & Adam Jaffe, 1997. "University Versus Corporate Patents: A Window On The Basicness Of Invention," Economics of Innovation and New Technology, Taylor & Francis Journals, vol. 5(1), pages 19-50.
- Ulrich, Karl, 1995. "The role of product architecture in the manufacturing firm," Research Policy, Elsevier, vol. 24(3), pages 419-440, May.
- Orsenigo, L. & Pammolli, F. & Riccaboni, Massimo, 2001. "Technological change and network dynamics: Lessons from the pharmaceutical industry," Research Policy, Elsevier, vol. 30(3), pages 485-508, March.
- Nightingale, Paul, 2000. "Economies of Scale in Experimentation: Knowledge and Technology in Pharmaceutical R&D," Industrial and Corporate Change, Oxford University Press, vol. 9(2), pages 315-59, June.
- Narin, Francis & Olivastro, Dominic, 1992. "Status report: Linkage between technology and science," Research Policy, Elsevier, vol. 21(3), pages 237-249, June.
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