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The knowledge bases of the world's largest pharmaceutical groups: what do patent citations to non-patent literature reveal?

  • Stefano Brusoni
  • Paola Criscuolo
  • Aldo Geuna

This article examines the knowledge bases of the world's largest pharmaceutical groups by sales. It builds upon the concepts of knowledge specialisation and knowledge integration as the relevant dimensions along which knowledge bases can be mapped. The former is studied developing indicators of breadth. Breadth is measured by analysing the evolution of specialisation by scientific field over time. It hints at the widening range of bodies of scientific and technological knowledge relevant to firms' innovative activities. Knowledge integration is studied developing indicators of depth. Depth is measured by analysing the evolution of integration across different typologies of research. It hints at the complex, non-linear interdependencies that link the scientific and technological domains. We develop the analysis on the strength of an original database of 33,127 European Patent Office patents and 41,931 citations to 'non-patent document' (of which 19,494 were identified as scientific articles included in the ISI databases) of the 30 largest pharmaceuticals groups during the period 1990-1997. The groups studied seem to have incrementally increased the breadth of their knowledge bases, moving towards the fields proper to the new biopharmaceutical research trajectory. At the same time, some of the groups studied exhibit remarkable depth in knowledge integration in particular fields such as biotechnology, biochemical research and neurosciences.

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Article provided by Taylor & Francis Journals in its journal Economics of Innovation and New Technology.

Volume (Year): 14 (2005)
Issue (Month): 5 ()
Pages: 395-415

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Handle: RePEc:taf:ecinnt:v:14:y:2005:i:5:p:395-415
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  1. Adam B. Jaffe, 1986. "Technological Opportunity and Spillovers of R&D: Evidence from Firms' Patents, Profits and Market Value," NBER Working Papers 1815, National Bureau of Economic Research, Inc.
  2. Stefano Brusoni & Paola Criscuolo & Aldo Geuna, 2003. "The Knowledge Bases of the World's Largest Pharmaceuticals Groups: what do Patent Citations to Non-Patent Literature Reveal?," SPRU Working Paper Series 90, SPRU - Science and Technology Policy Research, University of Sussex.
  3. Rebecca Henderson & Iain Cockburn, 1996. "Scale, Scope, and Spillovers: The Determinants of Research Productivity in Drug Discovery," RAND Journal of Economics, The RAND Corporation, vol. 27(1), pages 32-59, Spring.
  4. Narin, Francis & Hamilton, Kimberly S. & Olivastro, Dominic, 1997. "The increasing linkage between U.S. technology and public science," Research Policy, Elsevier, vol. 26(3), pages 317-330, October.
  5. Narin, Francis & Olivastro, Dominic, 1992. "Status report: Linkage between technology and science," Research Policy, Elsevier, vol. 21(3), pages 237-249, June.
  6. Prencipe, Andrea, 2000. "Breadth and depth of technological capabilities in CoPS: the case of the aircraft engine control system," Research Policy, Elsevier, vol. 29(7-8), pages 895-911, August.
  7. Prencipe, Andrea, 1997. "Technological competencies and product's evolutionary dynamics a case study from the aero-engine industry," Research Policy, Elsevier, vol. 25(8), pages 1261-1276, January.
  8. Henderson, Rebecca. & Cockburn, Iain., 1994. "Measuring competence? : exploring firm effects in pharmaceutical research," Working papers 3712-94., Massachusetts Institute of Technology (MIT), Sloan School of Management.
  9. Manuel Trajtenberg & Rebecca Henderson & Adam Jaffe, 1997. "University Versus Corporate Patents: A Window On The Basicness Of Invention," Economics of Innovation and New Technology, Taylor & Francis Journals, vol. 5(1), pages 19-50.
  10. Narin, Francis & Rozek, Richard P., 1988. "Bibliometric analysis of U.S. pharmaceutical industry research performance," Research Policy, Elsevier, vol. 17(3), pages 139-154, June.
  11. Arora, Ashish & Gambardella, Alfonso, 1994. "The changing technology of technological change: general and abstract knowledge and the division of innovative labour," Research Policy, Elsevier, vol. 23(5), pages 523-532, September.
  12. Richard R. Nelson, 2003. "On the Uneven Evolution of Human Know-How," LEM Papers Series 2003/25, Laboratory of Economics and Management (LEM), Sant'Anna School of Advanced Studies, Pisa, Italy.
  13. Miller, Roger, et al, 1995. "Innovation in Complex Systems Industries: The Case of Flight Simulation," Industrial and Corporate Change, Oxford University Press, vol. 4(2), pages 363-400.
  14. Wang, Q. & von Tunzelmann, N., 2000. "Complexity and the functions of the firm: breadth and depth," Research Policy, Elsevier, vol. 29(7-8), pages 805-818, August.
  15. Meyer, Martin, 2000. "Does science push technology? Patents citing scientific literature," Research Policy, Elsevier, vol. 29(3), pages 409-434, March.
  16. Henderson, Rebecca., 1994. "The evolution of integrative capability : innovation in cardiovascular drug discovery," Working papers 3711-94., Massachusetts Institute of Technology (MIT), Sloan School of Management.
  17. Orsenigo, L. & Pammolli, F. & Riccaboni, Massimo, 2001. "Technological change and network dynamics: Lessons from the pharmaceutical industry," Research Policy, Elsevier, vol. 30(3), pages 485-508, March.
  18. Malo St├ęphane & Geuna Aldo, 1999. "Science-Technology Linkages in an Emerging Research Platform: The case of Combinatorial Chemistry and Biology," Research Memorandum 020, Maastricht University, Maastricht Economic Research Institute on Innovation and Technology (MERIT).
  19. Ulrich, Karl, 1995. "The role of product architecture in the manufacturing firm," Research Policy, Elsevier, vol. 24(3), pages 419-440, May.
  20. Tijssen, Robert J. W., 2002. "Science dependence of technologies: evidence from inventions and their inventors," Research Policy, Elsevier, vol. 31(4), pages 509-526, May.
  21. Nightingale, Paul, 2000. "Economies of Scale in Experimentation: Knowledge and Technology in Pharmaceutical R&D," Industrial and Corporate Change, Oxford University Press, vol. 9(2), pages 315-59, June.
  22. Soete, Luc, 1987. "The impact of technological innovation on international trade patterns: The evidence reconsidered," Research Policy, Elsevier, vol. 16(2-4), pages 101-130, August.
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