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Science-Technology Linkages in an Emerging Research Platform: The case of Combinatorial Chemistry and Biology

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  • Malo, Stéphane
  • Geuna, Aldo

    (MERIT)

Abstract

This article focuses on issues concerning science and technology relationships posed by the emergence of a new drug discovery method, namely, combinatorial chemistry and biology. We assess the scientific content of combinatorial chemistry and biology using citations in patents to scientific journals and compare this research platform with biotechnology. We also identify the institutional affiliation of all the authors of the cited papers, which leads us to an analysis of knowledge spillovers between the main participants in the research network. Finally, we examine the relevance of localisation in the process of knowledge exchange with regard to EU countries and the US. The result of the analysis provide evidence to support the view that the inventive capacity of a country is dependent upon the basic research which is carried out, especially in universities and public research centres located in the inventor''s country.

Suggested Citation

  • Malo, Stéphane & Geuna, Aldo, 1999. "Science-Technology Linkages in an Emerging Research Platform: The case of Combinatorial Chemistry and Biology," Research Memorandum 020, Maastricht University, Maastricht Economic Research Institute on Innovation and Technology (MERIT).
  • Handle: RePEc:unm:umamer:1999020
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    File URL: https://www.merit.unu.edu/publications/rmpdf/1999/rm1999-020.pdf
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    References listed on IDEAS

    as
    1. Collins, Peter & Wyatt, Suzanne, 1988. "Citations in patents to the basic research literature," Research Policy, Elsevier, vol. 17(2), pages 65-74, April.
    2. Adam B. Jaffe & Manuel Trajtenberg & Rebecca Henderson, 1993. "Geographic Localization of Knowledge Spillovers as Evidenced by Patent Citations," The Quarterly Journal of Economics, Oxford University Press, vol. 108(3), pages 577-598.
    3. Narin, Francis & Olivastro, Dominic, 1992. "Status report: Linkage between technology and science," Research Policy, Elsevier, vol. 21(3), pages 237-249, June.
    4. Jaffe, Adam B, 1989. "Real Effects of Academic Research," American Economic Review, American Economic Association, vol. 79(5), pages 957-970, December.
    5. van Vianen, B. G. & Moed, H. F. & van Raan, A. F. J., 1990. "An exploration of the science base of recent technology," Research Policy, Elsevier, vol. 19(1), pages 61-81, February.
    6. Nathan ROSENBERG, 2009. "Why do firms do basic research (with their own money)?," World Scientific Book Chapters,in: Studies On Science And The Innovation Process Selected Works of Nathan Rosenberg, chapter 11, pages 225-234 World Scientific Publishing Co. Pte. Ltd..
    7. Thomke, Stefan & von Hippel, Eric & Franke, Roland, 1998. "Modes of experimentation: an innovation process--and competitive--variable," Research Policy, Elsevier, vol. 27(3), pages 315-332, July.
    8. Narin, Francis & Hamilton, Kimberly S. & Olivastro, Dominic, 1997. "The increasing linkage between U.S. technology and public science," Research Policy, Elsevier, vol. 26(3), pages 317-330, October.
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    Citations

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    Cited by:

    1. Arundel, Anthony & Bordoy, Catalina, 2008. "Developing internationally comparable indicators for the commercialization of publicly-funded research," MERIT Working Papers 075, United Nations University - Maastricht Economic and Social Research Institute on Innovation and Technology (MERIT).
    2. Dan Marsh, 2000. "Fostering Innovation in a Small Open Economy: The Case of the New Zealand Biotechnology Sector," Working Papers in Economics 00/01, University of Waikato.
    3. repec:spr:scient:v:81:y:2009:i:3:d:10.1007_s11192-008-2224-3 is not listed on IDEAS
    4. Hector Gonzalo Ordóñez-Matamoros & Susan E. Cozzens & Margarita Garcia, 2010. "International Co-Authorship and Research Team Performance in Colombia," Review of Policy Research, Policy Studies Organization, vol. 27(4), pages 415-431, July.
    5. Fassio, Claudio & Geuna, Aldo & Rossi, Federica, 2014. "The Contribution of Academic Knowledge to the Value of Industry Inventions: Micro level evidence from patent inventors," Department of Economics and Statistics Cognetti de Martiis LEI & BRICK - Laboratory of Economics of Innovation "Franco Momigliano", Bureau of Research in Innovation, Complexity and Knowledge, Collegio 201408, University of Turin.
    6. Stefano Brusoni & Paola Criscuolo & Aldo Geuna, 2005. "The knowledge bases of the world's largest pharmaceutical groups: what do patent citations to non-patent literature reveal?," Economics of Innovation and New Technology, Taylor & Francis Journals, vol. 14(5), pages 395-415.
    7. repec:spr:scient:v:112:y:2017:i:3:d:10.1007_s11192-017-2437-4 is not listed on IDEAS
    8. Anthony Arundel & Aldo Geuna, 2001. "Does Proximity Matter for Knowledge Transfer from Public Institutes and Universities to Firms?," SPRU Working Paper Series 73, SPRU - Science and Technology Policy Research, University of Sussex.
    9. Dan Marsh, 2004. "Biotechnology in New Zealand," Working Papers in Economics 04/01, University of Waikato.
    10. repec:kap:sbusec:v:50:y:2018:i:4:d:10.1007_s11187-017-9894-2 is not listed on IDEAS

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