A scoping review on metrics to quantify reproducibility: a multitude of questions leads to a multitude of metrics

*Background:* Reproducibility is recognized as essential to scientific progress and integrity. Replication studies and large-scale replication projects, aiming to quantify different aspects of reproducibility, have become more common. Since no standardized approach to measuring reproducibility exists,a diverse set of metrics has emerged and a comprehensive overview is needed. *Methods:* We conducted a scoping review to identify large-scale replication projects that used metrics and methodological papers that proposed or discussed metrics. The project list was compiled by the authors. For the methodological papers, we searched Scopus, MedLine, PsycINFO andEconLit. Records were screened in duplicate against predefined inclusion criteria. Demographic information on included records and information on reproducibility metrics used, suggested or discussed was extracted. *Results:* We identified 49 large-scale projects and 97 methodological papers, and extracted 50 metrics. The metrics were characterized based on type (formulas and/or statistical models, frameworks, graphical representations, studies and questionnaires, algorithms), input required, and appropriate application scenarios. Each metric addresses a distinct question. *Conclusions:* Our review provides a comprehensive resource in the form of a “live”, interactive table for future replication teams and meta-researchers, offering support in how to select the most appropriate metrics that are aligned with research questions and project goals.