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Acquisitions, inventors’ turnover, and innovation: Evidence from the pharmaceutical industry

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  • Ornaghi, Carmine
  • Cassi, Lorenzo

Abstract

This paper examines the relationship between the post-merger decline in patenting among pharmaceutical firms, as observed in previous firm-level studies, and the following individual-level dynamics: (i) the exit of inventors from the innovation market, (ii) the departure of inventors from target firms to other research labs, and (iii) a decline in the innovative output of inventors who remain within the acquired firms. Using a large sample of target companies, we estimate that acquisitions are associated with an increase in exit rates of inventors between 7.6 and 17.5 percentage points and of their departure rates ranging from 12.2 to18.9 percentage points. We find similar results are obtained for large and small deals and that top inventors of targets are also more likely to exit or to leave when an acquisition takes place. Our results show that, for each inventor that exits the innovation market, around 2 patents are foregone, representing more than 30 percent loss of the expected output these scientists could have produced over their careers. Inventors who relocate to a different lab also generate 2 fewer patents compared to similar control scientists, representing a 30 percent decrease in their productivity too. Finally, inventors that stay at the acquired targets also experience a decrease in output of nearly one fewer patent. These results point to a significant decline in both human capital and consumer welfare, which call for a closer scrutiny of M&As.

Suggested Citation

  • Ornaghi, Carmine & Cassi, Lorenzo, 2026. "Acquisitions, inventors’ turnover, and innovation: Evidence from the pharmaceutical industry," European Economic Review, Elsevier, vol. 184(C).
  • Handle: RePEc:eee:eecrev:v:184:y:2026:i:c:s0014292126000073
    DOI: 10.1016/j.euroecorev.2026.105263
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    1. Gehrke, Britta & Maug, Ernst & Obernberger, Stefan & Schneider, Christoph, 2021. "Post-merger Restructuring of the Labor Force," IZA Discussion Papers 14409, IZA Network @ LISER.
    2. Comanor, William S. & Scherer, F.M., 2013. "Mergers and innovation in the pharmaceutical industry," Journal of Health Economics, Elsevier, vol. 32(1), pages 106-113.
    3. David J. Ravenscraft & William F. Long, 2000. "Paths to Creating Value in Pharmaceutical Mergers," NBER Chapters, in: Mergers and Productivity, pages 287-326, National Bureau of Economic Research, Inc.
    4. Daniel Tzabbar & Bruno Cirillo & Stefano Breschi, 2022. "The Differential Impact of Intrafirm Collaboration and Technological Network Centrality on Employees’ Likelihood of Leaving the Firm," Organization Science, INFORMS, vol. 33(6), pages 2250-2273, November.
    5. Colleen Cunningham & Florian Ederer & Song Ma, 2021. "Killer Acquisitions," Journal of Political Economy, University of Chicago Press, vol. 129(3), pages 649-702.
    6. Jacobson, Louis S & LaLonde, Robert J & Sullivan, Daniel G, 1993. "Earnings Losses of Displaced Workers," American Economic Review, American Economic Association, vol. 83(4), pages 685-709, September.
    7. Manuel Trajtenberg, 1990. "A Penny for Your Quotes: Patent Citations and the Value of Innovations," RAND Journal of Economics, The RAND Corporation, vol. 21(1), pages 172-187, Spring.
    8. Weiyi Ng & Toby E. Stuart, 2022. "Acquired employees versus hired employees: Retained or turned over?," Strategic Management Journal, Wiley Blackwell, vol. 43(5), pages 1025-1045, May.
    9. Louis S. Jacobson & Robert J. LaLonde & Daniel G. Sullivan, 1993. "Long-term earnings losses of high-seniority displaced workers," Economic Perspectives, Federal Reserve Bank of Chicago, vol. 17(Nov), pages 2-20.
    10. Michele Pezzoni & Francesco Lissoni & Gianluca Tarasconi, 2014. "How to kill inventors: testing the Massacrator© algorithm for inventor disambiguation," Scientometrics, Springer;Akadémiai Kiadó, vol. 101(1), pages 477-504, October.
    11. Ornaghi, Carmine, 2009. "Mergers and innovation in big pharma," International Journal of Industrial Organization, Elsevier, vol. 27(1), pages 70-79, January.
    12. Gilbert, Richard J & Greene, Hillary, 2015. "Merging Innovation into Antitrust Agency Enforcement of the Clayton Act," Department of Economics, Working Paper Series qt8c68x088, Department of Economics, Institute for Business and Economic Research, UC Berkeley.
    13. Federico, Giulio & Langus, Gregor & Valletti, Tommaso, 2017. "A simple model of mergers and innovation," Economics Letters, Elsevier, vol. 157(C), pages 136-140.
    14. DiMasi, Joseph A. & Hansen, Ronald W. & Grabowski, Henry G. & Lasagna, Louis, 1991. "Cost of innovation in the pharmaceutical industry," Journal of Health Economics, Elsevier, vol. 10(2), pages 107-142, July.
    15. Haucap, Justus & Rasch, Alexander & Stiebale, Joel, 2019. "How mergers affect innovation: Theory and evidence," International Journal of Industrial Organization, Elsevier, vol. 63(C), pages 283-325.
    16. Carmine Ornaghi, 2009. "Positive Assortive Merging," Journal of Economics & Management Strategy, Wiley Blackwell, vol. 18(2), pages 323-346, June.
    17. Henry Grabowski & Margaret Kyle, 2008. "Mergers and Alliances in Pharmaceuticals: Effects on Innovation and R&D Productivity," Chapters, in: Klaus Gugler & B. Burcin Yurtoglu (ed.), The Economics of Corporate Governance and Mergers, chapter 11, Edward Elgar Publishing.
    18. Thomas G. Wollmann, 2019. "Stealth Consolidation: Evidence from an Amendment to the Hart-Scott-Rodino Act," American Economic Review: Insights, American Economic Association, vol. 1(1), pages 77-94, June.
    19. Bennato, Anna Rita & Davies, Stephen & Mariuzzo, Franco & Ormosi, Peter, 2021. "Mergers and innovation: Evidence from the hard disk drive market," International Journal of Industrial Organization, Elsevier, vol. 77(C).
    20. Verginer, Luca & Riccaboni, Massimo, 2025. "The impact of biotech acquisitions on inventor productivity," Journal of Business Research, Elsevier, vol. 200(C).
    21. Cloodt, Myriam & Hagedoorn, John & Van Kranenburg, Hans, 2006. "Mergers and acquisitions: Their effect on the innovative performance of companies in high-tech industries," Research Policy, Elsevier, vol. 35(5), pages 642-654, June.
    22. Michele Pezzoni & Francesco Lissoni & Gianluca Tarasconi, 2014. "How to kill inventors: testing the Massacrator© algorithm for inventor disambiguation," Scientometrics, Springer;Akadémiai Kiadó, vol. 101(1), pages 477-504, October.
    23. Denicolò, Vincenzo & Polo, Michele, 2018. "Duplicative research, mergers and innovation," Economics Letters, Elsevier, vol. 166(C), pages 56-59.
    24. Mahdiyeh Entezarkheir & Saeed Moshiri, 2018. "Mergers and innovation: evidence from a panel of US firms," Economics of Innovation and New Technology, Taylor & Francis Journals, vol. 27(2), pages 132-153, February.
    25. Luca Verginer & Federica Parisi & Jeroen Lidth de Jeude & Massimo Riccaboni, 2025. "Acquisitions as catalysts for inventor departures in the biotechnology industry," Humanities and Social Sciences Communications, Palgrave Macmillan, vol. 12(1), pages 1-12, December.
    26. Hall, Bronwyn H & Ziedonis, Rosemarie Ham, 2001. "The Patent Paradox Revisited: An Empirical Study of Patenting in the U.S. Semiconductor Industry, 1979-1995," RAND Journal of Economics, The RAND Corporation, vol. 32(1), pages 101-128, Spring.
    27. Luis R Gómez-Mejia & Leslie E Palich, 1997. "Cultural Diversity and the Performance of Multinational Firms," Journal of International Business Studies, Palgrave Macmillan;Academy of International Business, vol. 28(2), pages 309-335, June.
    28. Hussinger, Katrin, 2007. "Inventors? Response to Firm Acquisitions," ZEW Discussion Papers 07-078, ZEW - Leibniz Centre for European Economic Research.
    29. Marta Lachowska & Alexandre Mas & Stephen A. Woodbury, 2020. "Sources of Displaced Workers' Long-Term Earnings Losses," American Economic Review, American Economic Association, vol. 110(10), pages 3231-3266, October.
    30. José Luis Moraga‐González & Evgenia Motchenkova & Saish Nevrekar, 2022. "Mergers and innovation portfolios," RAND Journal of Economics, RAND Corporation, vol. 53(4), pages 641-677, December.
    31. Colombo, Massimo G. & Rabbiosi, Larissa, 2014. "Technological similarity, post-acquisition R&D reorganization, and innovation performance in horizontal acquisitions," Research Policy, Elsevier, vol. 43(6), pages 1039-1054.
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    Keywords

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    JEL classification:

    • G34 - Financial Economics - - Corporate Finance and Governance - - - Mergers; Acquisitions; Restructuring; Corporate Governance
    • L41 - Industrial Organization - - Antitrust Issues and Policies - - - Monopolization; Horizontal Anticompetitive Practices
    • J63 - Labor and Demographic Economics - - Mobility, Unemployment, Vacancies, and Immigrant Workers - - - Turnover; Vacancies; Layoffs
    • O31 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - Innovation and Invention: Processes and Incentives
    • O32 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - Management of Technological Innovation and R&D

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