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Determinants of biopharmaceutical R&D expenditures in China: the impact of spatiotemporal context

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  • Jiafeng Gu

    (Peking University)

Abstract

The spatiotemporal context affects corporate behavior because any corporate activity is carried out in a specific time and space. Based on an examination on the research and development (R&D) expenditures of 284 listed biopharmaceutical companies in China, this study finds that the innovation space of the biopharmaceutical industry presents a spatial “North–South” pattern. The spatial gravity center of the biopharmaceutical industry’s R&D investment has been shifting to the eastern coastal region. This spatiotemporal context will impact the R&D investment of biopharmaceutical companies. Research shows that the distance between biopharmaceutical companies and the gravity center has a direct impact on the R&D expenditures of biopharmaceutical companies. This study supports the context-sensitive thesis and shows how the spatiotemporal context affects the R&D investment of biopharmaceutical companies while controlling firm-level factors.

Suggested Citation

  • Jiafeng Gu, 2021. "Determinants of biopharmaceutical R&D expenditures in China: the impact of spatiotemporal context," Scientometrics, Springer;Akadémiai Kiadó, vol. 126(8), pages 6659-6680, August.
    • Handle: RePEc:spr:scient:v:126:y:2021:i:8:d:10.1007_s11192-021-04058-y
    DOI: 10.1007/s11192-021-04058-y
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    as
    1. Wang, Eric C., 2010. "Determinants of R&D investment: The Extreme-Bounds-Analysis approach applied to 26 OECD countries," Research Policy, Elsevier, vol. 39(1), pages 103-116, February.
    2. Cellini, Roberto & Lambertini, Luca, 2009. "Dynamic R&D with spillovers: Competition vs cooperation," Journal of Economic Dynamics and Control, Elsevier, vol. 33(3), pages 568-582, March.
    3. Dolores Añón Higón & Miguel Manjón Antolín & Juan A. Mañez, 2011. "Multinationals, R&D, and productivity: evidence for UK manufacturing firms," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 20(2), pages 641-659, April.
    4. Changying Li & Jianhu Zhang, 2013. "Dynamic Games of R&D Competition in a Differentiated Duopoly," Journal of Institutional and Theoretical Economics (JITE), Mohr Siebeck, Tübingen, vol. 169(4), pages 660-679, December.
    5. Matsumura, Toshihiro & Matsushima, Noriaki, 2012. "Welfare properties of strategic R&D investments in Hotelling models," Economics Letters, Elsevier, vol. 115(3), pages 465-468.
    6. McCutchen, William Jr., 1993. "Estimating the impact of the R&D tax credit on strategic groups in the pharmaceutical industry," Research Policy, Elsevier, vol. 22(4), pages 337-351, August.
    7. Cabrer-Borras, Bernardi & Serrano-Domingo, Guadalupe, 2007. "Innovation and R&D spillover effects in Spanish regions: A spatial approach," Research Policy, Elsevier, vol. 36(9), pages 1357-1371, November.
    8. Hudgens, Michael G. & Halloran, M. Elizabeth, 2008. "Toward Causal Inference With Interference," Journal of the American Statistical Association, American Statistical Association, vol. 103, pages 832-842, June.
    9. Beñat Bilbao‐Osorio & Andrés Rodríguez‐Pose, 2004. "From R&D to Innovation and Economic Growth in the EU," Growth and Change, Wiley Blackwell, vol. 35(4), pages 434-455, September.
    10. Marino, Marianna & Lhuillery, Stephane & Parrotta, Pierpaolo & Sala, Davide, 2016. "Additionality or crowding-out? An overall evaluation of public R&D subsidy on private R&D expenditure," Research Policy, Elsevier, vol. 45(9), pages 1715-1730.
    11. Iain M. Cockburn & Matthew J. Slaughter, 2010. "The Global Location of Biopharmaceutical Knowledge Activity: New Findings, New Questions," Innovation Policy and the Economy, University of Chicago Press, vol. 10(1), pages 129-157.
    12. Goel, Rajeev K. & Haruna, Shoji, 2007. "Cooperative and noncooperative R&D with spillovers: The case of labor-managed firms," Economic Systems, Elsevier, vol. 31(4), pages 423-440, December.
    13. Tsai-Ling Liao & Wen-Chun Lin, 2017. "Corporate Governance, Product Market Competition, and the Wealth Effect of R&D Spending Changes," Financial Management, Financial Management Association International, vol. 46(3), pages 717-742, September.
    14. Joseph Golec & John Vernon, 2010. "Financial Effects of Pharmaceutical Price Regulation on R&D Spending by EU versus US Firms," PharmacoEconomics, Springer, vol. 28(8), pages 615-628, August.
    15. Luigi Orsenigo & Fabio Pammolli & Massimo Riccaboni & Andrea Bonaccorsi & Giuseppe Turchetti, 1997. "The Evolution of Knowledge and the Dynamics of an Industry Network," Journal of Management & Governance, Springer;Accademia Italiana di Economia Aziendale (AIDEA), vol. 1(2), pages 147-175, June.
    16. René Belderbos & Elissavet Lykogianni & Reinhilde Veugelers, 2008. "Strategic R&D Location by Multinational Firms: Spillovers, Technology Sourcing, and Competition," Journal of Economics & Management Strategy, Wiley Blackwell, vol. 17(3), pages 759-779, September.
    17. Hyunseog Chung & Soomin Eum & Chulung Lee, 2019. "Firm Growth and R&D in the Korean Pharmaceutical Industry," Sustainability, MDPI, vol. 11(10), pages 1-19, May.
    18. Satoshi Hayashi & Naoki Tsuge, 2019. "Necessary and sufficient condition for equilibrium of the Hotelling model on a circle," Papers 1910.11154, arXiv.org, revised Oct 2019.
    19. Jiafeng Gu, 2021. "Spatial Dynamics between Firm Sales and Environmental Responsibility: The Mediating Role of Corporate Innovation," Sustainability, MDPI, vol. 13(4), pages 1-18, February.
    20. Bryan P. Schmutz & Rexford E. Santerre, 2013. "Examining The Link Between Cash Flow, Market Value, And Research And Development Investment Spending In The Medical Device Industry," Health Economics, John Wiley & Sons, Ltd., vol. 22(2), pages 157-167, February.
    21. Sheng-qiang Jiang & An-na Shi & Zhi-hang Peng & Xin Li, 2017. "Major factors affecting cross-city R&D collaborations in China: evidence from cross-sectional co-patent data between 224 cities," Scientometrics, Springer;Akadémiai Kiadó, vol. 111(3), pages 1251-1266, June.
    22. M. Breton & A. Turki & G. Zaccour, 2004. "Dynamic Model of R&D, Spillovers, and Efficiency of Bertrand and Cournot Equilibria," Journal of Optimization Theory and Applications, Springer, vol. 123(1), pages 1-25, October.
    23. Smrkolj, Grega & Wagener, Florian, 2016. "Dynamic R&D with spillovers: A comment," Journal of Economic Dynamics and Control, Elsevier, vol. 73(C), pages 453-457.
    24. Satoshi Hayashi & Naoki Tsuge, 2019. "Necessary and sufficient condition for equilibrium of the Hotelling model," Papers 1907.06200, arXiv.org.
    25. Gamble, John E., 2000. "Management commitment to innovation and esop stock concentration," Journal of Business Venturing, Elsevier, vol. 15(5-6), pages 433-447.
    26. Dong, Jing & Gou, Yan-nan, 2010. "Corporate governance structure, managerial discretion, and the R&D investment in China," International Review of Economics & Finance, Elsevier, vol. 19(2), pages 180-188, April.
    27. Choi, Joonhwan & Lee, Jaegul, 2017. "Repairing the R&D market failure: Public R&D subsidy and the composition of private R&D," Research Policy, Elsevier, vol. 46(8), pages 1465-1478.
    28. Calvin Atewamba & Bruno Nkuiya, 2017. "Testing the Assumptions and Predictions of the Hotelling Model," Environmental & Resource Economics, Springer;European Association of Environmental and Resource Economists, vol. 66(1), pages 169-203, January.
    29. André Spithoven & Peter Teirlinck, 2002. "The spatial dimension of the R&D expenditures in the Belgian enterprise sector," Brussels Economic Review, ULB -- Universite Libre de Bruxelles, vol. 45(4), pages 157-186.
    30. Rachel Hilliard & David Jacobson, 2011. "Cluster versus Firm-specific Factors in the Development of Dynamic Capabilities in the Pharmaceutical Industry in Ireland: A Study of Responses to Changes in Environmental Protection Regulations," Regional Studies, Taylor & Francis Journals, vol. 45(10), pages 1319-1328, November.
    31. Nightingale, Paul, 2000. "Economies of Scale in Experimentation: Knowledge and Technology in Pharmaceutical R&D," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 9(2), pages 315-359, June.
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    1. Jiafeng Gu, 2021. "Effects of Patent Policy on Outputs and Commercialization of Academic Patents in China: A Spatial Difference-in-Differences Analysis," Sustainability, MDPI, vol. 13(23), pages 1-17, December.

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