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Retirement Age and the Age of Onset of Alzheimer’s Disease: Results from the ICTUS Study

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  • Catherine Grotz
  • Luc Letenneur
  • Eric Bonsang
  • Hélène Amieva
  • Céline Meillon
  • Etienne Quertemont
  • Eric Salmon
  • Stéphane Adam
  • ICTUS/DSA group

Abstract

Objectives: To test whether deferred retirement is associated with delayed onset of Alzheimer’s disease (AD), and, if so, to determine whether retirement age still predicts the age at onset of AD when two potential biases are considered. Methods: The study sample was gathered from the Impact of Cholinergic Treatment Use/Data Sharing Alzheimer cohort (ICTUS/DSA), a European study of 1,380 AD patients. Information regarding retirement age, onset of symptoms and covariates was collected at baseline whereas age at diagnosis was gathered from the patient’s medical record prior to study entry. Linear mixed models, adjusted for gender, education, occupation, center, country, household income, depression and cardiovascular risk factors were conducted on 815 patients. Results: (1) The global analyses (n = 815) revealed that later age at retirement was associated with later age at diagnosis (β = 0.31, p

Suggested Citation

  • Catherine Grotz & Luc Letenneur & Eric Bonsang & Hélène Amieva & Céline Meillon & Etienne Quertemont & Eric Salmon & Stéphane Adam & ICTUS/DSA group, 2015. "Retirement Age and the Age of Onset of Alzheimer’s Disease: Results from the ICTUS Study," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-11, February.
    • Handle: RePEc:plo:pone00:0115056
    DOI: 10.1371/journal.pone.0115056
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    References listed on IDEAS

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    1. Mazzonna, Fabrizio & Peracchi, Franco, 2012. "Ageing, cognitive abilities and retirement," European Economic Review, Elsevier, vol. 56(4), pages 691-710.
    2. Bonsang, Eric & Adam, Stéphane & Perelman, Sergio, 2012. "Does retirement affect cognitive functioning?," Journal of Health Economics, Elsevier, vol. 31(3), pages 490-501.
    3. Ertel, K.A. & Glymour, M.M. & Berkman, L.F., 2008. "Effects of social integration on preserving memory function in a nationally representative US elderly population," American Journal of Public Health, American Public Health Association, vol. 98(7), pages 1215-1220.
    4. Crooks, V.C. & Lubben, J. & Petitti, D.B. & Little, D. & Chiu, V., 2008. "Social network, cognitive function, and dementia incidence among elderly women," American Journal of Public Health, American Public Health Association, vol. 98(7), pages 1221-1227.
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    Cited by:

    1. Keane, M.P. & Thorp, S., 2016. "Complex Decision Making," Handbook of the Economics of Population Aging, in: Piggott, John & Woodland, Alan (ed.), Handbook of the Economics of Population Aging, edition 1, volume 1, chapter 0, pages 661-709, Elsevier.

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