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A Study of Gene-Environment Interactions In Entrepreneurship

Author

Listed:
  • Quaye Lydia

    (King’s College London)

  • Nicolaou Nicos

    (University of Cyprus & Cass Business School, City University)

  • Shane Scott

    (Case Western Reserve University)

  • Harris Juliette

    (King’s College London)

Abstract

We examined the interactions between four genes associated with dyslexia (ROBO1, KIAA0319, DCDC2, DYX1C1) and education on the tendency to become an entrepreneur. We used a two-staged design consisting of a discovery sample of 692 individuals, and a replication sample of 797 participants from the TwinsUK cohort. Associations were identified between entrepreneurship and interactions of education and ROBO1 rs654867 and KIAA0319 rs6902039 with the stage 1 samples. However these were not independently replicated and the associations were no longer significant when the samples from the 2 stages were combined. A tagging SNP approach was used to investigate the effect of the interactions between education and 191 tagging SNPs from the candidate genes on entrepreneurship. While we found several significant interactions (DCDC2, KIAA0319 and ROBO1), none passed the stringent threshold for significance of a Bonferroni correction. Similar to the case with other behavioural genetics phenotypes, large sample sizes will be required to identify significant gene-environment interactions in entrepreneurship after making Bonferroni corrections.

Suggested Citation

  • Quaye Lydia & Nicolaou Nicos & Shane Scott & Harris Juliette, 2012. "A Study of Gene-Environment Interactions In Entrepreneurship," Entrepreneurship Research Journal, De Gruyter, vol. 2(2), pages 1-20, March.
    • Handle: RePEc:bpj:erjour:v:2:y:2012:i:2:n:1
    DOI: 10.1515/2157-5665.1053
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    References listed on IDEAS

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    Cited by:

    1. Nicos Nicolaou & Phillip H. Phan & Ute Stephan, 2021. "The Biological Perspective in Entrepreneurship Research," Entrepreneurship Theory and Practice, , vol. 45(1), pages 3-17, January.
    2. Shane, Scott & Nicolaou, Nicos, 2015. "Creative personality, opportunity recognition and the tendency to start businesses: A study of their genetic predispositions," Journal of Business Venturing, Elsevier, vol. 30(3), pages 407-419.
    3. Krammer, Sorin M.S. & Gören, Erkan, 2021. "Wired in? Genetic traits and entrepreneurship around the world," Technological Forecasting and Social Change, Elsevier, vol. 168(C).
    4. Nicos Nicolaou & Pankaj C. Patel & Marcus T. Wolfe, 2018. "Testosterone and Tendency to Engage in Self-Employment," Management Science, INFORMS, vol. 64(4), pages 1825-1841, April.
    5. Graciela Kuechle, 2019. "The contribution of behavior genetics to entrepreneurship: An evolutionary perspective," Journal of Evolutionary Economics, Springer, vol. 29(4), pages 1263-1284, September.

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