IDEAS home Printed from https://ideas.repec.org/p/hal/journl/hal-00660923.html
   My bibliography  Save this paper

Adherence to and effectiveness of Highly Active Antiretroviral Treatment for HIV infection: assessing the bidirectional relationship

Author

Listed:
  • Karine Lamiraud

    (Economics Department - Essec Business School)

  • Jean-Paul Moatti

    (SESSTIM - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale - IRD - Institut de Recherche pour le Développement - AMU - Aix Marseille Université - ORS PACA - INSERM - Institut National de la Santé et de la Recherche Médicale)

  • François Raffi

    (Maladies infectieuses et tropicales)

  • Maria Patrizia Carrieri

    (SESSTIM - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale - IRD - Institut de Recherche pour le Développement - AMU - Aix Marseille Université - ORS PACA - INSERM - Institut National de la Santé et de la Recherche Médicale)

  • Camelia Protopopescu

    (SESSTIM - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale - IRD - Institut de Recherche pour le Développement - AMU - Aix Marseille Université - ORS PACA - INSERM - Institut National de la Santé et de la Recherche Médicale)

  • Christian Michelet

    (Service des maladies infectieuses et réanimation médicale - UR1 - Université de Rennes 1 - UNIV-RENNES - Université de Rennes - Hôpital Pontchaillou)

  • Luminita Schneider

    (Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière] - Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Pitié-Salpêtrière [APHP])

  • Fidéline Collin

    (Epidémiologie et Biostatistique [Bordeaux] - Université Bordeaux Segalen - Bordeaux 2 - Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED) - INSERM - Institut National de la Santé et de la Recherche Médicale)

  • Catherine Leport

    (Laboratoire de recherche en pathologie infectieuse - Assistance publique - Hôpitaux de Paris (AP-HP) - AP-HP - Hôpital Bichat - Claude Bernard [Paris] - UPD7 - Université Paris Diderot - Paris 7)

  • Bruno Spire

    (SESSTIM - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale - IRD - Institut de Recherche pour le Développement - AMU - Aix Marseille Université - ORS PACA - INSERM - Institut National de la Santé et de la Recherche Médicale)

Abstract

It is well-established that high adherence to HAART is a major determinant of virological and immunological success. Furthermore, psycho-social research has identified a wide range of adherence factors. Our objective was to assess the bi-directional relationship between adherence and response to treatment among patients enrolled in the ANRS CO8 APROCOCOPILOTE study. An econometric approach was implemented through a bivariate twoequation simultaneous system, studying the factors associated with both adherence and undetectability of HIV plasma viral load. Our results highlight that good biological results induced by adherence reinforce continued adherence. This strengthens the argument that patients who do not experience rapid improvements in their immunological and clinical statuses after HAART initiation should be prioritized when developing adherence support interventions. Furthermore, it rules out the hypothesis that HAART leads to "false reassurance" among HIV infected patients.

Suggested Citation

  • Karine Lamiraud & Jean-Paul Moatti & François Raffi & Maria Patrizia Carrieri & Camelia Protopopescu & Christian Michelet & Luminita Schneider & Fidéline Collin & Catherine Leport & Bruno Spire, 2011. "Adherence to and effectiveness of Highly Active Antiretroviral Treatment for HIV infection: assessing the bidirectional relationship," Post-Print hal-00660923, HAL.
  • Handle: RePEc:hal:journl:hal-00660923
    Note: View the original document on HAL open archive server: https://hal-essec.archives-ouvertes.fr/hal-00660923
    as

    Download full text from publisher

    File URL: https://hal-essec.archives-ouvertes.fr/hal-00660923/document
    Download Restriction: no

    Other versions of this item:

    References listed on IDEAS

    as
    1. Jeffrey M. Wooldridge, 2005. "Simple solutions to the initial conditions problem in dynamic, nonlinear panel data models with unobserved heterogeneity," Journal of Applied Econometrics, John Wiley & Sons, Ltd., vol. 20(1), pages 39-54.
    2. Guilkey, David K. & Murphy, James L., 1993. "Estimation and testing in the random effects probit model," Journal of Econometrics, Elsevier, vol. 59(3), pages 301-317, October.
    Full references (including those not matched with items on IDEAS)

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:hal:journl:hal-00660923. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (CCSD). General contact details of provider: https://hal.archives-ouvertes.fr/ .

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service hosted by the Research Division of the Federal Reserve Bank of St. Louis . RePEc uses bibliographic data supplied by the respective publishers.