IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0179222.html

Reduction in all-cause otitis media-related outpatient visits in children after PCV10 introduction in Brazil

Author

Listed:
  • Ana L Sartori
  • Ruth Minamisava
  • Ana L Bierrenbach
  • Cristiana M Toscano
  • Eliane T Afonso
  • Otaliba L Morais-Neto
  • José L F Antunes
  • Elier B Cristo
  • Ana Lucia Andrade

Abstract

Few studies have reported the effect of 10-valent pneumococcal conjugate vaccine (PCV10) on otitis media (OM) in infants. In particular, no population-based study in upper-middle income countries is available. In 2010, Brazil introduced PCV10 into its routine National Immunization Program using a 3+1 schedule. We measured the impact of PCV10 on all-cause OM in children. An interrupted time-series analysis was conducted in Goiânia/Brazil considering monthly rates (per 100,000) of all-cause OM outpatient visits in children aged 2–23 months. We used case-based data from the Outpatient Visits Information System of the Unified Health System coded for ICD-10 diagnosis for the period of August/2008 to July/2015. As a comparator, we used rates of outpatient visits due to all-other causes. The relative reduction of all-cause OM and all-other causes of outpatient visits were calculated as the difference between the predicted and observed cumulative rates of the PCV10 post-vaccination period. We then subtracted the relative reduction of all-other causes of outpatient visits from all-cause OM to obtain the impact of PCV10 on OM. In total, 6,401 OM outpatient visits were recorded in 4,793 children aged 2–23 months. Of these, 922 (19.2%) children had more than one OM episode. A significant reduction in all-cause OM visits was observed (50.7%; 95%CI: 42.2–59.2%; p = 0.013), while the reduction in visits due to all-other causes was 7.7% (95% CI 0.8–14.7%; p

Suggested Citation

  • Ana L Sartori & Ruth Minamisava & Ana L Bierrenbach & Cristiana M Toscano & Eliane T Afonso & Otaliba L Morais-Neto & José L F Antunes & Elier B Cristo & Ana Lucia Andrade, 2017. "Reduction in all-cause otitis media-related outpatient visits in children after PCV10 introduction in Brazil," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-13, June.
    • Handle: RePEc:plo:pone00:0179222
    DOI: 10.1371/journal.pone.0179222
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179222
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0179222&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0179222?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Romero Rocha & Rodrigo R. Soares, 2010. "Evaluating the impact of community‐based health interventions: evidence from Brazil's Family Health Program," Health Economics, John Wiley & Sons, Ltd., vol. 19(S1), pages 126-158, September.
    2. Ferreira Filho, Joaquim Bento de Souza & Horridge, Mark Jonathan, 2006. "Economic Integration, Poverty and Regional Inequality in Brazil," Revista Brasileira de Economia - RBE, EPGE Brazilian School of Economics and Finance - FGV EPGE (Brazil), vol. 60(4), February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Arief Anshory Yusuf, 2008. "INDONESIA-E3: An Indonesian Applied General Equilibrium Model for Analyzing the Economy, Equity, and the Environment," Working Papers in Economics and Development Studies (WoPEDS) 200804, Department of Economics, Padjadjaran University, revised Sep 2008.
    2. David Roodman, 2020. "The impact of life-saving interventions on fertility," Papers 2007.11388, arXiv.org.
    3. Sun, Yucheng & Li, Jiaolong & Shen, Xiuheng & Pan, Zhewen, 2025. "Early-life access to primary healthcare and educational attainment: Evidence from community health centers in China," Social Science & Medicine, Elsevier, vol. 380(C).
    4. Resul Cesur & Pinar Mine Gunes & Erdal Tekin & Aydogan Ulker, 2023. "Socialized Healthcare and Women’s Fertility Decisions," Journal of Human Resources, University of Wisconsin Press, vol. 58(3), pages 1028-1055.
    5. Wittwer, Glyn, 2022. "Preparing a multi-country, sub-national CGE model: EuroTERM including Ukraine," Conference papers 333470, Purdue University, Center for Global Trade Analysis, Global Trade Analysis Project.
    6. Marie Daumal, 2013. "The Impact of Trade Openness on Regional Inequality: The Cases of India and Brazil," The International Trade Journal, Taylor & Francis Journals, vol. 27(3), pages 243-280, August.
    7. Ricardo Argüello & Daniel Valderrama-Gonzalez, 2015. "Sectoral and poverty impacts of agricultural policy adjustments in Colombia," Agricultural Economics, International Association of Agricultural Economists, vol. 46(2), pages 259-280, March.
    8. Vânia Cristina Campelo Barroso Carneiro & Paulo de Tarso Ribeiro de Oliveira & Saul Rassy Carneiro & Marinalva Cardoso Maciel & Janari da Silva Pedroso, 2021. "Evidence of the effect of primary care expansion on hospitalizations: Panel analysis of 143 municipalities in the Brazilian Amazon," PLOS ONE, Public Library of Science, vol. 16(4), pages 1-14, April.
    9. Bratta, Barbara & Carta, Silvia & Di Caro, Paolo & Manzo, Marco & Orecchia, Carlo, 2025. "Welfare and equity impact of consumption tax policies: A micro-macro-economic approach applied to Italy," Economic Systems, Elsevier, vol. 49(3).
    10. Marcelo Castro & Enlinson Mattos & Fernanda Patriota, 2021. "The effects of health spending on the propagation of infectious diseases," Health Economics, John Wiley & Sons, Ltd., vol. 30(10), pages 2323-2344, September.
    11. Bhalotra, Sonia & Rocha, Rudi & R. Soares, Rodigo, 2016. "Does universalization of health work? Evidence from health systems restructuring and maternal and child health in Brazil," ISER Working Paper Series 2016-16, Institute for Social and Economic Research.
    12. Bancalari, Antonella & Berlinski, Samuel & Buitrago, Giancarlo & García, María Fernanda & Mata, Dolores de la & Vera-Hernández, Marcos, 2023. "Health Inequalities in Latin American and the Caribbean: Child, Adolescent, Reproductive, Metabolic Syndrome and Mental Health," IDB Publications (Working Papers) 13158, Inter-American Development Bank.
    13. Singhal, Sonica & Correa, Rejane & Quiñonez, Carlos, 2013. "The impact of dental treatment on employment outcomes: A systematic review," Health Policy, Elsevier, vol. 109(1), pages 88-96.
    14. Gleiton Lima Araújo & Fábio Ferreira Amorim & Rafaela Cristina Pereira Santos de Miranda & Flávio Ferreira Pontes Amorim & Levy Aniceto Santana & Leila Bernarda Donato Göttems, 2022. "Patient safety culture in primary health care: Medical office survey on patient safety culture in a Brazilian family health strategy setting," PLOS ONE, Public Library of Science, vol. 17(7), pages 1-16, July.
    15. Mateus Dias & Luiz Felipe Fontes, 2024. "The Effects of a Large-Scale Mental Health Reform: Evidence from Brazil," American Economic Journal: Economic Policy, American Economic Association, vol. 16(3), pages 257-289, August.
    16. Bhalotra, Sonia & Nunes, Letícia & Rocha, Rudi, 2026. "Emergency care centers, hospital performance and population health," Journal of Public Economics, Elsevier, vol. 255(C).
    17. repec:dau:papers:123456789/4295 is not listed on IDEAS
    18. Vinícius Halmenschlager & Alexandre Nunes de Almeida & Felipe Garcia Ribeiro & Carolina Silva da Trindade, 2025. "The Effects of Hydrological Disasters on the Population's Health in the Northeast Region of Brazil," Health Economics, John Wiley & Sons, Ltd., vol. 34(5), pages 855-868, May.
    19. Bhalotra, Sonia R. & Rocha, Rudi & Soares, Rodrigo R., 2019. "Does Universalization of Health Work? Evidence from Health Systems Restructuring and Expansion in Brazil," IZA Discussion Papers 12111, IZA Network @ LISER.
    20. Mrejen, Matías & Rocha, Rudi, 2025. "Hiring mental health professionals: Evidence from a large-scale policy in Brazil," Labour Economics, Elsevier, vol. 94(C).
    21. Mattos, Enlinson & Mazetto, Debora, 2019. "Assessing the impact of more doctors’ program on healthcare indicators in Brazil," World Development, Elsevier, vol. 123(C), pages 1-1.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0179222. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.