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Less is more: Antibiotics at the beginning of life

Author

Listed:
  • Martin Stocker

    (Children’s Hospital Lucerne)

  • Claus Klingenberg

    (UiT-The Arctic University of Norway
    University Hospital of North Norway)

  • Lars Navér

    (Karolinska University Hospital
    Karolinska Institutet)

  • Viveka Nordberg

    (Karolinska University Hospital
    Karolinska Institutet)

  • Alberto Berardi

    (Policlinico University Hospital)

  • Salhab el Helou

    (McMaster University, Hamilton Health Sciences)

  • Gerhard Fusch

    (McMaster University, Hamilton Health Sciences)

  • Joseph M. Bliss

    (Warren Alpert Medical School of Brown University)

  • Dirk Lehnick

    (University of Lucerne)

  • Varvara Dimopoulou

    (Lausanne University Hospital and University of Lausanne)

  • Nicholas Guerina

    (Warren Alpert Medical School of Brown University)

  • Joanna Seliga-Siwecka

    (Medical University of Warsaw)

  • Pierre Maton

    (Clinique CHC-Montlegia, groupe santé CHC)

  • Donatienne Lagae

    (CHIREC-Delta Hospital)

  • Judit Mari

    (University of Szeged)

  • Jan Janota

    (Motol University Hospital Prague
    Thomayer University Hospital Prague)

  • Philipp K. A. Agyeman

    (Bern University Hospital, University of Bern)

  • Riccardo Pfister

    (Geneva University Hospitals and Geneva University)

  • Giuseppe Latorre

    (Ecclesiastical General Hospital F. Miulli)

  • Gianfranco Maffei

    (Policlinico Riuniti Foggia)

  • Nichola Laforgia

    (University of Bari)

  • Enikő Mózes

    (Semmelweis University)

  • Ketil Størdal

    (University of Oslo and Oslo University Hospital)

  • Tobias Strunk

    (King Edward Memorial Hospital)

  • Eric Giannoni

    (Lausanne University Hospital and University of Lausanne)

Abstract

Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver for antibiotic overtreatment early in life. Bias (a systemic deviation towards overtreatment) and noise (a random scatter) affect the decision-making process. In this perspective, we advocate for a factual approach quantifying the burden of treatment in relation to the burden of disease balancing antimicrobial stewardship and effective sepsis management.

Suggested Citation

  • Martin Stocker & Claus Klingenberg & Lars Navér & Viveka Nordberg & Alberto Berardi & Salhab el Helou & Gerhard Fusch & Joseph M. Bliss & Dirk Lehnick & Varvara Dimopoulou & Nicholas Guerina & Joanna , 2023. "Less is more: Antibiotics at the beginning of life," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38156-7
    DOI: 10.1038/s41467-023-38156-7
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    References listed on IDEAS

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