IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-34502-3.html
   My bibliography  Save this article

Gut microbiome-wide association study of depressive symptoms

Author

Listed:
  • Djawad Radjabzadeh

    (Erasmus Medical Center Rotterdam)

  • Jos A. Bosch

    (University of Amsterdam
    Amsterdam University Medical Centers)

  • André G. Uitterlinden

    (Erasmus Medical Center Rotterdam
    Erasmus MC University Medical Center Rotterdam)

  • Aeilko H. Zwinderman

    (Amsterdam University Medical Centers)

  • M. Arfan Ikram

    (Erasmus MC University Medical Center Rotterdam)

  • Joyce B. J. Meurs

    (Erasmus Medical Center Rotterdam)

  • Annemarie I. Luik

    (Erasmus MC University Medical Center Rotterdam)

  • Max Nieuwdorp

    (Amsterdam University Medical Centers, Location AMC)

  • Anja Lok

    (Location AMC)

  • Cornelia M. Duijn

    (Erasmus MC University Medical Center Rotterdam
    Oxford University)

  • Robert Kraaij

    (Erasmus Medical Center Rotterdam)

  • Najaf Amin

    (Erasmus MC University Medical Center Rotterdam
    Oxford University)

Abstract

Depression is one of the most poorly understood diseases due to its elusive pathogenesis. There is an urgency to identify molecular and biological mechanisms underlying depression and the gut microbiome is a novel area of interest. Here we investigate the relation of fecal microbiome diversity and composition with depressive symptoms in 1,054 participants from the Rotterdam Study cohort and validate these findings in the Amsterdam HELIUS cohort in 1,539 subjects. We identify association of thirteen microbial taxa, including genera Eggerthella, Subdoligranulum, Coprococcus, Sellimonas, Lachnoclostridium, Hungatella, Ruminococcaceae (UCG002, UCG003 and UCG005), LachnospiraceaeUCG001, Eubacterium ventriosum and Ruminococcusgauvreauiigroup, and family Ruminococcaceae with depressive symptoms. These bacteria are known to be involved in the synthesis of glutamate, butyrate, serotonin and gamma amino butyric acid (GABA), which are key neurotransmitters for depression. Our study suggests that the gut microbiome composition may play a key role in depression.

Suggested Citation

  • Djawad Radjabzadeh & Jos A. Bosch & André G. Uitterlinden & Aeilko H. Zwinderman & M. Arfan Ikram & Joyce B. J. Meurs & Annemarie I. Luik & Max Nieuwdorp & Anja Lok & Cornelia M. Duijn & Robert Kraaij, 2022. "Gut microbiome-wide association study of depressive symptoms," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34502-3
    DOI: 10.1038/s41467-022-34502-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-34502-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-34502-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Stephen Nayfach & Zhou Jason Shi & Rekha Seshadri & Katherine S. Pollard & Nikos C. Kyrpides, 2019. "New insights from uncultivated genomes of the global human gut microbiome," Nature, Nature, vol. 568(7753), pages 505-510, April.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Martin Stocker & Claus Klingenberg & Lars Navér & Viveka Nordberg & Alberto Berardi & Salhab el Helou & Gerhard Fusch & Joseph M. Bliss & Dirk Lehnick & Varvara Dimopoulou & Nicholas Guerina & Joanna , 2023. "Less is more: Antibiotics at the beginning of life," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Li Zhang & Karen R. Jonscher & Zuyuan Zhang & Yi Xiong & Ryan S. Mueller & Jacob E. Friedman & Chongle Pan, 2022. "Islet autoantibody seroconversion in type-1 diabetes is associated with metagenome-assembled genomes in infant gut microbiomes," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Adina Howe & Nejc Stopnisek & Shane K. Dooley & Fan Yang & Keara L. Grady & Ashley Shade, 2023. "Seasonal activities of the phyllosphere microbiome of perennial crops," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Bin Ma & Caiyu Lu & Yiling Wang & Jingwen Yu & Kankan Zhao & Ran Xue & Hao Ren & Xiaofei Lv & Ronghui Pan & Jiabao Zhang & Yongguan Zhu & Jianming Xu, 2023. "A genomic catalogue of soil microbiomes boosts mining of biodiversity and genetic resources," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Fiona B. Tamburini & Dylan Maghini & Ovokeraye H. Oduaran & Ryan Brewster & Michaella R. Hulley & Venesa Sahibdeen & Shane A. Norris & Stephen Tollman & Kathleen Kahn & Ryan G. Wagner & Alisha N. Wade, 2022. "Short- and long-read metagenomics of urban and rural South African gut microbiomes reveal a transitional composition and undescribed taxa," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    5. Sigal Leviatan & Saar Shoer & Daphna Rothschild & Maria Gorodetski & Eran Segal, 2022. "An expanded reference map of the human gut microbiome reveals hundreds of previously unknown species," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    6. Joe J. Lim & Christian Diener & James Wilson & Jacob J. Valenzuela & Nitin S. Baliga & Sean M. Gibbons, 2023. "Growth phase estimation for abundant bacterial populations sampled longitudinally from human stool metagenomes," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    7. Elio L Herzog & Melania Wäfler & Irene Keller & Sebastian Wolf & Martin S Zinkernagel & Denise C Zysset-Burri, 2021. "The importance of age in compositional and functional profiling of the human intestinal microbiome," PLOS ONE, Public Library of Science, vol. 16(10), pages 1-13, October.
    8. Chan Yeong Kim & Junyeong Ma & Insuk Lee, 2022. "HiFi metagenomic sequencing enables assembly of accurate and complete genomes from human gut microbiota," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    9. Ziye Wang & Ronghui You & Haitao Han & Wei Liu & Fengzhu Sun & Shanfeng Zhu, 2024. "Effective binning of metagenomic contigs using contrastive multi-view representation learning," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    10. Shuqin Zeng & Dhrati Patangia & Alexandre Almeida & Zhemin Zhou & Dezhi Mu & R. Paul Ross & Catherine Stanton & Shaopu Wang, 2022. "A compendium of 32,277 metagenome-assembled genomes and over 80 million genes from the early-life human gut microbiome," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    11. Mingyue Cheng & Shuai Luo & Peng Zhang & Guangzhou Xiong & Kai Chen & Chuanqi Jiang & Fangdian Yang & Hanhui Huang & Pengshuo Yang & Guanxi Liu & Yuhao Zhang & Sang Ba & Ping Yin & Jie Xiong & Wei Mia, 2024. "A genome and gene catalog of the aquatic microbiomes of the Tibetan Plateau," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34502-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.