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Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)

Author

Listed:
  • Yifei Zhang

    (Ruijin Hospital, Shanghai Jiao Tong University School of Medicine)

  • Yanyun Gu

    (Ruijin Hospital, Shanghai Jiao Tong University School of Medicine)

  • Huahui Ren

    (BGI-Shenzhen)

  • Shujie Wang

    (Ruijin Hospital, Shanghai Jiao Tong University School of Medicine)

  • Huanzi Zhong

    (BGI-Shenzhen)

  • Xinjie Zhao

    (Chinese Academy of Science)

  • Jing Ma

    (Shanghai Jiao Tong University School of Medicine)

  • Xuejiang Gu

    (The First Affiliated hospital of Wenzhou Medical University)

  • Yaoming Xue

    (Southern Medical University)

  • Shan Huang

    (Shanghai Jiao Tong University School of Medicine)

  • Jialin Yang

    (Central Hospital of Minhang District)

  • Li Chen

    (Qilu Hospital of Shandong University)

  • Gang Chen

    (Fujian Provincial Hospital)

  • Shen Qu

    (Shanghai Tenth People’s Hospital of Tong Ji University)

  • Jun Liang

    (Xuzhou Central Hospital)

  • Li Qin

    (Shanghai Jiao Tong University School of Medicine)

  • Qin Huang

    (Second Military Medical University)

  • Yongde Peng

    (Shanghai Jiao Tong University School of Medicine)

  • Qi Li

    (Chinese Academy of Science)

  • Xiaolin Wang

    (Chinese Academy of Science)

  • Ping Kong

    (BGI-Shenzhen)

  • Guixue Hou

    (BGI-Shenzhen)

  • Mengyu Gao

    (BGI-Shenzhen)

  • Zhun Shi

    (BGI-Shenzhen)

  • Xuelin Li

    (Ruijin Hospital, Shanghai Jiao Tong University School of Medicine)

  • Yixuan Qiu

    (Ruijin Hospital, Shanghai Jiao Tong University School of Medicine)

  • Yuanqiang Zou

    (BGI-Shenzhen)

  • Huanming Yang

    (BGI-Shenzhen
    James D. Watson Institute of Genome Sciences)

  • Jian Wang

    (BGI-Shenzhen
    James D. Watson Institute of Genome Sciences)

  • Guowang Xu

    (Chinese Academy of Science)

  • Shenghan Lai

    (Johns Hopkins University School of Medicine)

  • Junhua Li

    (BGI-Shenzhen
    South China University of Technology)

  • Guang Ning

    (Ruijin Hospital, Shanghai Jiao Tong University School of Medicine)

  • Weiqing Wang

    (Ruijin Hospital, Shanghai Jiao Tong University School of Medicine)

Abstract

Human gut microbiome is a promising target for managing type 2 diabetes (T2D). Measures altering gut microbiota like oral intake of probiotics or berberine (BBR), a bacteriostatic agent, merit metabolic homoeostasis. We hence conducted a randomized, double-blind, placebo-controlled trial with newly diagnosed T2D patients from 20 centres in China. Four-hundred-nine eligible participants were enroled, randomly assigned (1:1:1:1) and completed a 12-week treatment of either BBR-alone, probiotics+BBR, probiotics-alone, or placebo, after a one-week run-in of gentamycin pretreatment. The changes in glycated haemoglobin, as the primary outcome, in the probiotics+BBR (least-squares mean [95% CI], −1.04[−1.19, −0.89]%) and BBR-alone group (−0.99[−1.16, −0.83]%) were significantly greater than that in the placebo and probiotics-alone groups (−0.59[−0.75, −0.44]%, −0.53[−0.68, −0.37]%, P

Suggested Citation

  • Yifei Zhang & Yanyun Gu & Huahui Ren & Shujie Wang & Huanzi Zhong & Xinjie Zhao & Jing Ma & Xuejiang Gu & Yaoming Xue & Shan Huang & Jialin Yang & Li Chen & Gang Chen & Shen Qu & Jun Liang & Li Qin & , 2020. "Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18414-8
    DOI: 10.1038/s41467-020-18414-8
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    Cited by:

    1. Eryun Zhang & Alon Agua & Wendong Huang, 2023. "A gut feeling for drugs that have metabolic benefits," Nature Communications, Nature, vol. 14(1), pages 1-4, December.
    2. Martin Stocker & Claus Klingenberg & Lars Navér & Viveka Nordberg & Alberto Berardi & Salhab el Helou & Gerhard Fusch & Joseph M. Bliss & Dirk Lehnick & Varvara Dimopoulou & Nicholas Guerina & Joanna , 2023. "Less is more: Antibiotics at the beginning of life," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

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