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Associations of the COMT Val158Met polymorphism with working memory and intelligence – A review and meta-analysis

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  • Geller, Susann
  • Wilhelm, Oliver
  • Wacker, Jan
  • Hamm, Alfons
  • Hildebrandt, Andrea

Abstract

The Val158Met polymorphism influences the activity of the Catechol-O-Methyl-Transferase (COMT), an enzyme involved in dopamine metabolism. Dopamine availability is vital for prefrontal functions. Therefore researchers claimed that Val158Met is causal for cognitive abilities. Published findings from single studies report mixed results. This meta-analysis examines the COMT genotype associations with working memory and intelligence in healthy populations. A systematic literature search was conducted yielding 412 studies, 58 of which could be included in the meta-analyses. There were no substantial COMT Val158Met effects on cognitive abilities, showing that either the true effect is zero or too small to be uncovered due to insufficient power of the analysis. The discussion focuses on power issues in research synthesis in general and their implications concerning the relation of Val158Met with working memory and intelligence in specific. Desiderata for research synthesis closely resemble those formulated in the open science framework: fully transparent single study design and data use of scientifically recommended methodologies.

Suggested Citation

  • Geller, Susann & Wilhelm, Oliver & Wacker, Jan & Hamm, Alfons & Hildebrandt, Andrea, 2017. "Associations of the COMT Val158Met polymorphism with working memory and intelligence – A review and meta-analysis," Intelligence, Elsevier, vol. 65(C), pages 75-92.
    • Handle: RePEc:eee:intell:v:65:y:2017:i:c:p:75-92
    DOI: 10.1016/j.intell.2017.09.002
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    References listed on IDEAS

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    1. Viechtbauer, Wolfgang, 2010. "Conducting Meta-Analyses in R with the metafor Package," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 36(i03).
    2. Sue Duval & Richard Tweedie, 2000. "Trim and Fill: A Simple Funnel-Plot–Based Method of Testing and Adjusting for Publication Bias in Meta-Analysis," Biometrics, The International Biometric Society, vol. 56(2), pages 455-463, June.
    3. Shoko Tsuchimine & Norio Yasui-Furukori & Ayako Kaneda & Sunao Kaneko, 2013. "Differential Effects of the Catechol-O-Methyltransferase Val158Met Genotype on the Cognitive Function of Schizophrenia Patients and Healthy Japanese Individuals," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
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