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A systematic review and meta-analysis of experimental methods for modulating intrusive memories following lab-analogue trauma exposure in non-clinical populations

Author

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  • Mohith M. Varma

    (Hong Kong Baptist University
    The University of Hong Kong)

  • Shengzi Zeng

    (The University of Hong Kong
    The University of Hong Kong
    Beth Israel Deaconess Medical Center
    Harvard Medical School)

  • Laura Singh

    (Uppsala University
    Swedish Collegium for Advanced Study)

  • Emily A. Holmes

    (Uppsala University)

  • Jingyun Huang

    (Sun Yat-sen University)

  • Man Hey Chiu

    (The University of Hong Kong)

  • Xiaoqing Hu

    (The University of Hong Kong
    The University of Hong Kong
    HKU-Shenzhen Institute of Research and Innovation)

Abstract

Experiencing trauma leads to intrusive memories (IMs), a hallmark symptom of post-traumatic stress disorder (PTSD), which also occurs transdiagnostically. Understanding why IMs increase or decrease is pivotal in developing interventions to support mental health. In this preregistered meta-analysis (PROSPERO: CRD42021224835), we included 134 articles (131 techniques, 606 effect sizes and 12,074 non-clinical participants) to investigate how experimental techniques alter IM frequency, intrusion-related distress and symptoms arising from lab-analogue trauma exposure. Eligible articles were identified by searching eight databases until 12 December 2023. To test potential publication biases, we employed methods including Egger’s test and three-parameter selection models. We employed three-level multilevel modelling and meta-regressions to examine whether and how experimental techniques would modulate IM frequency and associated outcomes. Results showed that techniques (behavioural, pharmacological, neuromodulation) significantly reduced intrusion frequency (g = 0.16, 95% confidence interval [0.09, 0.23]). Notably, techniques aimed to reduce IMs also ameliorated intrusion-related distress and symptoms, while techniques that increased IMs exacerbated these related outcomes, thus highlighting IM’s centrality in PTSD-like symptoms. Techniques tapping into mental imagery processing (for example, trauma reminder followed by playing Tetris) reduced intrusions when administered immediately after, or at a delayed time after trauma. Although our meta-analysis is limited to symptoms induced by lab-analogue trauma exposure, some lab-based results have now generalized to real-world trauma and IMs, highlighting the promising utility of lab-analogue trauma paradigms for intervention development.

Suggested Citation

  • Mohith M. Varma & Shengzi Zeng & Laura Singh & Emily A. Holmes & Jingyun Huang & Man Hey Chiu & Xiaoqing Hu, 2024. "A systematic review and meta-analysis of experimental methods for modulating intrusive memories following lab-analogue trauma exposure in non-clinical populations," Nature Human Behaviour, Nature, vol. 8(10), pages 1968-1987, October.
    • Handle: RePEc:nat:nathum:v:8:y:2024:i:10:d:10.1038_s41562-024-01956-y
    DOI: 10.1038/s41562-024-01956-y
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    References listed on IDEAS

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