Sequential Monte Carlo for Bayesian sequentially designed experiments for discrete data
In this paper we present a sequential Monte Carlo algorithm for Bayesian sequential experimental design applied to generalised non-linear models for discrete data. The approach is computationally convenient in that the information of newly observed data can be incorporated through a simple re-weighting step. We also consider a flexible parametric model for the stimulus–response relationship together with a newly developed hybrid design utility that can produce more robust estimates of the target stimulus in the presence of substantial model and parameter uncertainty. The algorithm is applied to hypothetical clinical trial or bioassay scenarios. In the discussion, potential generalisations of the algorithm are suggested to possibly extend its applicability to a wide variety of scenarios.
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.
References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Pierre Del Moral & Arnaud Doucet & Ajay Jasra, 2006. "Sequential Monte Carlo samplers," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 68(3), pages 411-436.
- Stefanie Biedermann & David C. Woods, 2011. "Optimal designs for generalized non‐linear models with application to second‐harmonic generation experiments," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 60(2), pages 281-299, 03.
- Nicolas Chopin, 2000.
"A Sequential Particle Filter Method for Static Models,"
2000-45, Centre de Recherche en Economie et Statistique.
- Nicolas Chopin, 2002. "A sequential particle filter method for static models," Biometrika, Biometrika Trust, vol. 89(3), pages 539-552, August.
- C. C. Drovandi & A. N. Pettitt, 2011. "Estimation of Parameters for Macroparasite Population Evolution Using Approximate Bayesian Computation," Biometrics, The International Biometric Society, vol. 67(1), pages 225-233, 03.
- N. Friel & A. N. Pettitt, 2008. "Marginal likelihood estimation via power posteriors," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 70(3), pages 589-607.
- Dror, Hovav A. & Steinberg, David M., 2008. "Sequential Experimental Designs for Generalized Linear Models," Journal of the American Statistical Association, American Statistical Association, vol. 103, pages 288-298, March.
When requesting a correction, please mention this item's handle: RePEc:eee:csdana:v:57:y:2013:i:1:p:320-335. See general information about how to correct material in RePEc.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Zhang, Lei)
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If references are entirely missing, you can add them using this form.
If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.
Please note that corrections may take a couple of weeks to filter through the various RePEc services.