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Sequential Monte Carlo for Bayesian sequentially designed experiments for discrete data

Listed author(s):
  • Drovandi, Christopher C.
  • McGree, James M.
  • Pettitt, Anthony N.
Registered author(s):

    In this paper we present a sequential Monte Carlo algorithm for Bayesian sequential experimental design applied to generalised non-linear models for discrete data. The approach is computationally convenient in that the information of newly observed data can be incorporated through a simple re-weighting step. We also consider a flexible parametric model for the stimulus–response relationship together with a newly developed hybrid design utility that can produce more robust estimates of the target stimulus in the presence of substantial model and parameter uncertainty. The algorithm is applied to hypothetical clinical trial or bioassay scenarios. In the discussion, potential generalisations of the algorithm are suggested to possibly extend its applicability to a wide variety of scenarios.

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    Article provided by Elsevier in its journal Computational Statistics & Data Analysis.

    Volume (Year): 57 (2013)
    Issue (Month): 1 ()
    Pages: 320-335

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    Handle: RePEc:eee:csdana:v:57:y:2013:i:1:p:320-335
    DOI: 10.1016/j.csda.2012.05.014
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    1. C. C. Drovandi & A. N. Pettitt, 2011. "Estimation of Parameters for Macroparasite Population Evolution Using Approximate Bayesian Computation," Biometrics, The International Biometric Society, vol. 67(1), pages 225-233, March.
    2. Pierre Del Moral & Arnaud Doucet & Ajay Jasra, 2006. "Sequential Monte Carlo samplers," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 68(3), pages 411-436.
    3. Stefanie Biedermann & David C. Woods, 2011. "Optimal designs for generalized non‐linear models with application to second‐harmonic generation experiments," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 60(2), pages 281-299, March.
    4. Nicolas Chopin, 2002. "A sequential particle filter method for static models," Biometrika, Biometrika Trust, vol. 89(3), pages 539-552, August.
    5. N. Friel & A. N. Pettitt, 2008. "Marginal likelihood estimation via power posteriors," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 70(3), pages 589-607.
    6. Dror, Hovav A. & Steinberg, David M., 2008. "Sequential Experimental Designs for Generalized Linear Models," Journal of the American Statistical Association, American Statistical Association, vol. 103, pages 288-298, March.
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