IDEAS home Printed from https://ideas.repec.org/p/egu/wpaper/1304.html
   My bibliography  Save this paper

Scientific Knowledge Dynamics and Relatedness in Bio-Tech Cities

Author

Listed:
  • Ron Boschma

    ()

  • Gaston Heimeriks

    ()

  • Pierre-Alexandre Balland

    ()

Abstract

This paper investigates the impact of scientific relatedness on knowledge dynamics in biotech at the city level during the period 1989-2008. We assess the extent to which the emergence of new research topics and the disappearance of existing topics in cities are dependent on their degree of scientific relatedness with existing topics in those cities. We make use of the rise and fall of title words in scientific publications in biotech to identify major cognitive developments within the field. We determined the degree of relatedness between 1,028 scientific topics in biotech by means of co-occurrence of pairs of topics in journal articles. We combined this relatedness indicator between topics in biotech with the scientific portfolio of cities (i.e. the topics on which they published previously) to determine how cognitively close a potentially new topic (or an existing topic) is to the scientific portfolio of a city. We analyzed knowledge dynamics at the city level by looking at the entry and exit of topics in the scientific portfolio of 276 cities in the world. We found strong and robust evidence that new scientific topics in biotech tend to emerge systematically in cities where scientifically related topics already exist, while existing scientific topics had a higher probability to disappear from a city when these were weakly related to the scientific portfolio of the city.

Suggested Citation

  • Ron Boschma & Gaston Heimeriks & Pierre-Alexandre Balland, 2013. "Scientific Knowledge Dynamics and Relatedness in Bio-Tech Cities," Papers in Evolutionary Economic Geography (PEEG) 1304, Utrecht University, Department of Human Geography and Spatial Planning, Group Economic Geography, revised Apr 2013.
  • Handle: RePEc:egu:wpaper:1304
    as

    Download full text from publisher

    File URL: http://econ.geo.uu.nl/peeg/peeg1304.pdf
    File Function: Version April 2013
    Download Restriction: no

    Other versions of this item:

    References listed on IDEAS

    as
    1. C. Antonelli, 2007. "Localized Technological Change," Chapters,in: Elgar Companion to Neo-Schumpeterian Economics, chapter 16 Edward Elgar Publishing.
    2. Frank Neffke & Martin Henning & Ron Boschma, 2011. "How Do Regions Diversify over Time? Industry Relatedness and the Development of New Growth Paths in Regions," Economic Geography, Clark University, vol. 87(3), pages 237-265, July.
    3. repec:spr:scient:v:68:y:2006:i:3:d:10.1007_s11192-006-0118-9 is not listed on IDEAS
    4. Ron Boschma & Asier Minondo & Mikel Navarro, 2013. "The Emergence of New Industries at the Regional Level in S pain: A Proximity Approach Based on Product Relatedness," Economic Geography, Clark University, vol. 89(1), pages 29-51, January.
    5. Asheim, Bjorn T & Isaksen, Arne, 2002. "Regional Innovation Systems: The Integration of Local 'Sticky' and Global 'Ubiquitous' Knowledge," The Journal of Technology Transfer, Springer, vol. 27(1), pages 77-86, January.
    6. Jarno Hoekman & Koen Frenken & Frank Oort, 2009. "The geography of collaborative knowledge production in Europe," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 43(3), pages 721-738, September.
    7. Martin, Roman & Moodysson , Jerker, 2011. "Comparing knowledge bases: on the organisation and geography of knowledge flows in the regional innovation system of Scania, southern Sweden," Papers in Innovation Studies 2011/2, Lund University, CIRCLE - Center for Innovation, Research and Competences in the Learning Economy.
    8. C. A. Hidalgo & B. Klinger & A. -L. Barabasi & R. Hausmann, 2007. "The Product Space Conditions the Development of Nations," Papers 0708.2090, arXiv.org.
    9. Hoekman, Jarno & Frenken, Koen & Tijssen, Robert J.W., 2010. "Research collaboration at a distance: Changing spatial patterns of scientific collaboration within Europe," Research Policy, Elsevier, vol. 39(5), pages 662-673, June.
    10. Lynne G. Zucker & Michael R. Darby, 2009. "Star Scientists, Innovation and Regional and National Immigration," Chapters,in: Entrepreneurship and Openness, chapter 6 Edward Elgar Publishing.
    11. Heiner, Ronald A, 1983. "The Origin of Predictable Behavior," American Economic Review, American Economic Association, vol. 73(4), pages 560-595, September.
    12. Trippl, Michaela, 2009. "Islands of Innovation and Internationally Networked Labor Markets. Magnetic Centers for Star Scientists?," SRE-Discussion Papers 138, WU Vienna University of Economics and Business.
    13. Jackie Krafft & Francesco Quatraro & Pier Paolo Saviotti, 2011. "The knowledge-base evolution in biotechnology: a social network analysis," Economics of Innovation and New Technology, Taylor & Francis Journals, vol. 20(5), pages 445-475.
    14. M. S. Gertler & Y. M. Levitte, 2005. "Local Nodes in Global Networks: The Geography of Knowledge Flows in Biotechnology Innovation," Industry and Innovation, Taylor & Francis Journals, vol. 12(4), pages 487-507.
    15. Asheim, Bjorn T. & Coenen, Lars, 2005. "Knowledge bases and regional innovation systems: Comparing Nordic clusters," Research Policy, Elsevier, vol. 34(8), pages 1173-1190, October.
    16. van Eck, N.J.P. & Waltman, L., 2009. "How to Normalize Co-Occurrence Data? An Analysis of Some Well-Known Similarity Measures," ERIM Report Series Research in Management ERS-2009-001-LIS, Erasmus Research Institute of Management (ERIM), ERIM is the joint research institute of the Rotterdam School of Management, Erasmus University and the Erasmus School of Economics (ESE) at Erasmus University Rotterdam.
    17. Gaston Heimeriks & Ron Boschma, 2014. "The path- and place-dependent nature of scientific knowledge production in biotech 1986–2008," Journal of Economic Geography, Oxford University Press, vol. 14(2), pages 339-364.
    18. Phil Cooke, 2006. "Global Bioregions: Knowledge Domains, Capabilities and Innovation System Networks," Industry and Innovation, Taylor & Francis Journals, vol. 13(4), pages 437-458.
    19. Meric S. Gertler, 2003. "Tacit knowledge and the economic geography of context, or The undefinable tacitness of being (there)," Journal of Economic Geography, Oxford University Press, vol. 3(1), pages 75-99, January.
    20. Frenken, Koen & Hardeman, Sjoerd & Hoekman, Jarno, 2009. "Spatial scientometrics: Towards a cumulative research program," Journal of Informetrics, Elsevier, vol. 3(3), pages 222-232.
    21. Dosi, Giovanni, 1993. "Technological paradigms and technological trajectories : A suggested interpretation of the determinants and directions of technical change," Research Policy, Elsevier, vol. 22(2), pages 102-103, April.
    22. Cohen, Wesley M & Levinthal, Daniel A, 1989. "Innovation and Learning: The Two Faces of R&D," Economic Journal, Royal Economic Society, vol. 99(397), pages 569-596, September.
    23. Steven Klepper, 2007. "Disagreements, Spinoffs, and the Evolution of Detroit as the Capital of the U.S. Automobile Industry," Management Science, INFORMS, vol. 53(4), pages 616-631, April.
    24. Jeffrey M. Wooldridge, 2003. "Cluster-Sample Methods in Applied Econometrics," American Economic Review, American Economic Association, vol. 93(2), pages 133-138, May.
    25. Lucio-Arias, Diana & Leydesdorff, Loet, 2009. "The dynamics of exchanges and references among scientific texts, and the autopoiesis of discursive knowledge," Journal of Informetrics, Elsevier, vol. 3(3), pages 261-271.
    26. Stefano Breschi & Francesco Lissoni, 2009. "Mobility of skilled workers and co-invention networks: an anatomy of localized knowledge flows," Journal of Economic Geography, Oxford University Press, vol. 9(4), pages 439-468, July.
    27. Todtling, Franz & Trippl, Michaela, 2005. "One size fits all?: Towards a differentiated regional innovation policy approach," Research Policy, Elsevier, vol. 34(8), pages 1203-1219, October.
    28. Ash Amin & Patrick Cohendet, 2000. "Organisational Learning and Governance Through Embedded Practices," Journal of Management & Governance, Springer;Accademia Italiana di Economia Aziendale (AIDEA), vol. 4(1), pages 93-116, March.
    29. Simone Strambach & Benjamin Klement, 2011. "Cumulative and Combinatorial Micro-dynamics of Knowledge: The Role of Space and Place in Knowledge Integration," European Planning Studies, Taylor & Francis Journals, vol. 20(11), pages 1843-1866, November.
    30. Roberta Capello, 1999. "Spatial Transfer of Knowledge in High Technology Milieux: Learning Versus Collective Learning Processes," Regional Studies, Taylor & Francis Journals, vol. 33(4), pages 353-365.
    31. Ron Boschma, 2004. "Competitiveness of Regions from an Evolutionary Perspective," Regional Studies, Taylor & Francis Journals, vol. 38(9), pages 1001-1014.
    32. Gaston Heimeriks, 2012. "Interdisciplinarity in biotechnology, genomics and nanotechnology," Science and Public Policy, Oxford University Press, vol. 40(1), pages 97-112, September.
    33. Leydesdroff, Loet, 1989. "Words and co-words as indicators of intellectual organization," Research Policy, Elsevier, vol. 18(4), pages 209-223, August.
    34. Rikard H. Eriksson, 2011. "Localized Spillovers and Knowledge Flows: How Does Proximity Influence the Performance of Plants?," Economic Geography, Clark University, vol. 87(2), pages 127-152, April.
    35. Atkinson, Anthony B & Stiglitz, Joseph E, 1969. "A New View of Technological Change," Economic Journal, Royal Economic Society, vol. 79(315), pages 573-578, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Breul Moritz & Broekel Tom & Brachert Matthias, 2015. "Die Treiber der räumlichen Emergenz und Konzentration der Photovoltaik- Industrie in Deutschland," Zeitschrift für Wirtschaftsgeographie, De Gruyter, vol. 59(3), pages 133-150, December.
    2. Ron Boschma, 2015. "Towards an Evolutionary Perspective on Regional Resilience," Regional Studies, Taylor & Francis Journals, vol. 49(5), pages 733-751, May.
    3. van Rijnsoever, Frank J. & van den Berg, Jesse & Koch, Joost & Hekkert, Marko P., 2015. "Smart innovation policy: How network position and project composition affect the diversity of an emerging technology," Research Policy, Elsevier, vol. 44(5), pages 1094-1107.
    4. Gaston Heimeriks & Pierre-Alexandre Balland, 2016. "How smart is specialisation? An analysis of specialisation patterns in knowledge production," Science and Public Policy, Oxford University Press, vol. 43(4), pages 562-574.
    5. Matthias Firgo & Peter Mayerhofer, 2015. "Wissens-Spillovers und regionale Entwicklung - welche strukturpolitische Ausrichtung optimiert des Wachstum?," Working Paper Reihe der AK Wien - Materialien zu Wirtschaft und Gesellschaft 144, Kammer für Arbeiter und Angestellte für Wien, Abteilung Wirtschaftswissenschaft und Statistik.
    6. Koen Frenken, 2016. "A Complexity-Theoretic Perspective on Innovation Policy," Papers in Evolutionary Economic Geography (PEEG) 1619, Utrecht University, Department of Human Geography and Spatial Planning, Group Economic Geography, revised Aug 2016.
    7. Guan, Jiancheng & Liu, Na, 2015. "Invention profiles and uneven growth in the field of emerging nano-energy," Energy Policy, Elsevier, vol. 76(C), pages 146-157.
    8. Alkemade, Floortje & Heimeriks, Gaston & Schoen, Antoine & Villard, Lionel & Laurens, Patricia, 2015. "Tracking the internationalization of multinational corporate inventive activity: national and sectoral characteristics," Research Policy, Elsevier, vol. 44(9), pages 1763-1772.
    9. Sandro Montresor & Francesco Quatraro, 2015. "Do Key Enabling Technologies shape regional Smart Specialization Strategies? A patent based analysis of European data," Department of Economics and Statistics Cognetti de Martiis LEI & BRICK - Laboratory of Economics of Innovation "Franco Momigliano", Bureau of Research in Innovation, Complexity and Knowledge, Collegio 201506, University of Turin.
    10. repec:spr:scient:v:113:y:2017:i:2:d:10.1007_s11192-017-2488-6 is not listed on IDEAS
    11. Sandro Montresor & Francesco Quatraro, 2015. "Smart Specialization Strategies and Key Enabling Technologies. Regional evidence from European patent data," Papers in Evolutionary Economic Geography (PEEG) 1525, Utrecht University, Department of Human Geography and Spatial Planning, Group Economic Geography, revised Aug 2015.
    12. Ron Boschma, 2014. "Constructing Regional Advantage and Smart Specialisation: Comparison of Two European Policy Concepts," SCIENZE REGIONALI, FrancoAngeli Editore, vol. 2014(1), pages 51-68.
    13. Antonelli, Cristiano & Feder, Christophe & Quatraro, Francesco, 2018. "Directed Technological Change and Technological Congruence: A New Framework for the Smart Specialization Strategy," Department of Economics and Statistics Cognetti de Martiis. Working Papers 201805, University of Turin.
    14. repec:spr:scient:v:115:y:2018:i:1:d:10.1007_s11192-018-2638-5 is not listed on IDEAS
    15. repec:spr:scient:v:112:y:2017:i:1:d:10.1007_s11192-017-2355-5 is not listed on IDEAS
    16. repec:spr:scient:v:102:y:2015:i:2:d:10.1007_s11192-014-1487-0 is not listed on IDEAS
    17. repec:wfo:wstudy:58342 is not listed on IDEAS
    18. Sandro Montresor & Francesco Quatraro,, 2018. "Green Technologies and Smart Specialisation Strategies: A European Patent-Based Analysis of the Intertwining of Technological Relatedness and Key-Enabling-Technologies," Department of Economics and Statistics Cognetti de Martiis. Working Papers 201808, University of Turin.
    19. Ron Boschma & Carlo Gianelle, 2014. "Regional Branching and Smart Specialisation Policy," JRC Working Papers JRC88242, Joint Research Centre (Seville site).
    20. Ron Boschma, 2017. "Relatedness as driver behind regional diversification: a research agenda," Papers in Evolutionary Economic Geography (PEEG) 1702, Utrecht University, Department of Human Geography and Spatial Planning, Group Economic Geography, revised Jan 2017.
    21. Ron Boschma, Lars Coenen, Koen Frenken, Bernhard Truffer & Lars Coenen & Koen Frenken & Bernhard Truffer, 2016. "Towards a theory of regional diversification," Papers in Evolutionary Economic Geography (PEEG) 1617, Utrecht University, Department of Human Geography and Spatial Planning, Group Economic Geography, revised Jul 2016.
    22. repec:taf:eurpls:v:24:y:2016:i:12:p:2097-2112 is not listed on IDEAS
    23. Jeroen Content & Koen Frenken, 2016. "Related variety and economic development: a literature review," European Planning Studies, Taylor & Francis Journals, vol. 24(12), pages 2097-2112, December.
    24. Vida Patrik, 2016. "The Potential of Biotechnology Investments in Selected Eastern European Countries: Lost Chances," Business Systems Research, De Gruyter Open, vol. 7(1), pages 16-34, March.
    25. Elekes, Zoltán, 2016. "A regionális növekedés új tényezői az evolúciós gazdaságföldrajzi kutatásokban. A változatosság és a technológiai közelség
      [The new factors of regional growth in research into evolutionary economic
      ," Közgazdasági Szemle (Economic Review - monthly of the Hungarian Academy of Sciences), Közgazdasági Szemle Alapítvány (Economic Review Foundation), vol. 0(3), pages 307-329.

    More about this item

    Keywords

    relatedness; co-occurrence analysis; knowledge dynamics; geography of biotech; title words;

    JEL classification:

    • O33 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - Technological Change: Choices and Consequences; Diffusion Processes
    • R11 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General Regional Economics - - - Regional Economic Activity: Growth, Development, Environmental Issues, and Changes
    • L65 - Industrial Organization - - Industry Studies: Manufacturing - - - Chemicals; Rubber; Drugs; Biotechnology; Plastics
    • D83 - Microeconomics - - Information, Knowledge, and Uncertainty - - - Search; Learning; Information and Knowledge; Communication; Belief; Unawareness

    NEP fields

    This paper has been announced in the following NEP Reports:

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:egu:wpaper:1304. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (). General contact details of provider: http://edirc.repec.org/data/deguunl.html .

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service hosted by the Research Division of the Federal Reserve Bank of St. Louis . RePEc uses bibliographic data supplied by the respective publishers.