IDEAS home Printed from https://ideas.repec.org/a/wly/mgtdec/v47y2026i1p109-125.html

Research on the Driving Mechanism of Network Structure of Patent‐Intensive Industrial Clusters: Taking Biopharmaceutical Industry as an Example

Author

Listed:
  • Lanqing Ge
  • Chunyan Li
  • Deli Cheng

Abstract

Against the backdrop of profound economic restructuring, the establishment of patent‐intensive industrial cluster networks is of great significance for enhancing China's overall innovation capacity and propelling industrial transformation and upgrading. This study takes the biopharmaceutical industry as an example, utilizing patent data spanning from 2012 to 2023 to construct an innovation network. It delves into the spatial distribution characteristics of patent‐intensive industrial clusters at the urban scale. Furthermore, a temporal exponential random graph model (TERGM) is employed to uncover the multidimensional dynamics driving network evolution. The findings reveal that cities ranking high in various centrality measures within the biopharmaceutical industrial cluster network exhibit stability, with a notable concentration in the eastern coastal regions. Spatial correlations within the cluster network are primarily driven by spillover effects across sectors. The biopharmaceutical industrial cluster network demonstrates positive mediation and transitive effects, accompanied by negative agglomeration effects. Factors such as economic development, the level of openness, heterogeneity in administrative hierarchies, government support levels, and multidimensional proximity among cities all contribute to driving the formation and evolution of the network. The conclusions broaden the application of innovation network theory within the specific context of China and provide a scientific basis for decision‐making in fostering patent‐intensive industrial clusters.

Suggested Citation

  • Lanqing Ge & Chunyan Li & Deli Cheng, 2026. "Research on the Driving Mechanism of Network Structure of Patent‐Intensive Industrial Clusters: Taking Biopharmaceutical Industry as an Example," Managerial and Decision Economics, John Wiley & Sons, Ltd., vol. 47(1), pages 109-125, January.
  • Handle: RePEc:wly:mgtdec:v:47:y:2026:i:1:p:109-125
    DOI: 10.1002/mde.70028
    as

    Download full text from publisher

    File URL: https://doi.org/10.1002/mde.70028
    Download Restriction: no

    File URL: https://libkey.io/10.1002/mde.70028?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Atiyeh Safardoust & Soroush Ghazinoori & Manouchehr Manteghi & Mohammad Naghizadeh & Jahanyar Bamdad Soofi, 2024. "Network Heterogeneity and Firm Performance: the Role of Network Capability," Journal of the Knowledge Economy, Springer;Portland International Center for Management of Engineering and Technology (PICMET), vol. 15(2), pages 8020-8052, June.
    2. Yasemin Limon & Tugce Martagan & Ananth Krishnamurthy, 2024. "Contracts for biopharmaceutical manufacturing based on production cost and capabilities," International Journal of Production Research, Taylor & Francis Journals, vol. 62(7), pages 2640-2662, April.
    3. John T. Scott, 2024. "The digital commercial revolution: U.S. business sales and the entrepreneurial exploitation of information and communications technology," The Journal of Technology Transfer, Springer, vol. 49(2), pages 401-436, April.
    4. Alberto Bettanti & Antonella Lanati & Alessandro Missoni, 2022. "Biopharmaceutical innovation ecosystems: a stakeholder model and the case of Lombardy," The Journal of Technology Transfer, Springer, vol. 47(6), pages 1948-1973, December.
    5. Renliang Liu & Thanasis Stengos & Yiguo Sun, 2024. "Spatial spillovers in trade agreement memberships: Does institutional proximity matter?," Review of International Economics, Wiley Blackwell, vol. 32(3), pages 1398-1433, August.
    6. Reinhold Kosfeld & Timo Mitze, 2023. "Research and development intensive clusters and regional competitiveness," Growth and Change, Wiley Blackwell, vol. 54(4), pages 885-911, December.
    7. Asheim, Bjorn T. & Coenen, Lars, 2005. "Knowledge bases and regional innovation systems: Comparing Nordic clusters," Research Policy, Elsevier, vol. 34(8), pages 1173-1190, October.
    8. Tahi, Sofiane & Khlif, Wafa & Belghoul, Khaled & Casadella, Vanessa, 2022. "Public-private innovation networks in services: Revisiting PPPs with servitization," Technovation, Elsevier, vol. 118(C).
    9. Liping Fu & Fan Wu & Shan Zhang, 2022. "Evolutionary Path and Innovative Development of Pharmaceutical Industrial Cluster—A Case Study of Shijiazhuang, China," IJERPH, MDPI, vol. 19(5), pages 1-18, March.
    10. Kerong Zhang & Wuyi Liu, 2020. "The Current Status, Trend, and Development Strategies of Chinese Biopharmaceutical Industry With a Challenging Perspective," SAGE Open, , vol. 10(1), pages 21582440209, January.
    11. Houxing Tang & Zhenzhong Ma & Lei Jing, 2024. "Interfirm Network Structure and Innovation Creation: a Simulation Study," Journal of the Knowledge Economy, Springer;Portland International Center for Management of Engineering and Technology (PICMET), vol. 15(2), pages 7622-7646, June.
    12. Lin, Runhui & Lu, Yanhong & Zhou, Cheng & Li, Biting, 2022. "Rethinking individual technological innovation: Cooperation network stability and the contingent effect of knowledge network attributes," Journal of Business Research, Elsevier, vol. 144(C), pages 366-376.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Atiyeh Safardoust & Fereidoun Mahboudi & Soode Mirmohammadi & Mohsen Pourqasem, 2026. "Intermediaries and Development of Biopharmaceuticals: Evidence From the Innovation Policy in a Developing Country," International Journal of Health Planning and Management, Wiley Blackwell, vol. 41(1), pages 132-155, January.
    2. Przygodzki, Zbigniew, . "Terytorialny wymiar kapitału ludzkiego," Gospodarka Narodowa-The Polish Journal of Economics, Szkoła Główna Handlowa w Warszawie / SGH Warsaw School of Economics, vol. 2019(4).
    3. Jarle Aarstad & Olav Andreas Kvitastein & Stig-Erik Jakobsen, 2019. "What Drives Enterprise Product Innovation? Assessing How Regional, National, And International Inter-Firm Collaboration Complement Or Substitute For R&D Investments," International Journal of Innovation Management (ijim), World Scientific Publishing Co. Pte. Ltd., vol. 23(05), pages 1-25, June.
    4. Cristina Chaminade & Monica Plechero, 2015. "Do Regions Make a Difference? Regional Innovation Systems and Global Innovation Networks in the ICT Industry," European Planning Studies, Taylor & Francis Journals, vol. 23(2), pages 215-237, February.
    5. Jianzhuang Zheng & Muhammad Usman Khurram & Lifeng Chen, 2022. "Can Green Innovation Affect ESG Ratings and Financial Performance? Evidence from Chinese GEM Listed Companies," Sustainability, MDPI, vol. 14(14), pages 1-32, July.
    6. Barge-Gil, Andrés & López, Alberto, 2014. "R&D determinants: Accounting for the differences between research and development," Research Policy, Elsevier, vol. 43(9), pages 1634-1648.
    7. Andrés Barge-Gil & Alberto López, 2015. "R versus D: estimating the differentiated effect of research and development on innovation results," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 24(1), pages 93-129.
    8. Souzanchi Kashani, Ebrahim & Roshani, Saeed, 2019. "Evolution of innovation system literature: Intellectual bases and emerging trends," Technological Forecasting and Social Change, Elsevier, vol. 146(C), pages 68-80.
    9. Murphree, Michael & Petersen, Bui & Warrian, Peter & Gosine, Ray, 2022. "Scope and scale of technology challenge and MNE subsidiary knowledge sourcing in host countries," Technovation, Elsevier, vol. 116(C).
    10. Lara Agostini & Federico Caviggioli & Francesco Galati & Barbara Bigliardi, 2020. "A social perspective of knowledge-based innovation: mobility and agglomeration. Introduction to the special section," The Journal of Technology Transfer, Springer, vol. 45(5), pages 1309-1323, October.
    11. Nanditha Mathew & George Paily, 2022. "STI-DUI innovation modes and firm performance in the Indian capital goods industry: Do small firms differ from large ones?," The Journal of Technology Transfer, Springer, vol. 47(2), pages 435-458, April.
    12. Andrés Barge-Gil & Elena Huergo & Alberto López & Lourdes Moreno, 2018. "Empirical models of firms’ R&D," Chapters, in: Luis C. Corchón & Marco A. Marini (ed.), Handbook of Game Theory and Industrial Organization, Volume II, chapter 18, pages 475-516, Edward Elgar Publishing.
    13. Radziwon, Agnieszka & Bogers, Marcel, 2019. "Open innovation in SMEs: Exploring inter-organizational relationships in an ecosystem," Technological Forecasting and Social Change, Elsevier, vol. 146(C), pages 573-587.
    14. Fragkandreas, Thanos, 2025. "Case study research on innovation systems: Paradox, dialectical analysis and resolution," Research Policy, Elsevier, vol. 54(1).
    15. Ferretti, Marco & Guerini, Massimiliano & Panetti, Eva & Parmentola, Adele, 2022. "The partner next door? The effect of micro-geographical proximity on intra-cluster inter-organizational relationships," Technovation, Elsevier, vol. 111(C).
    16. Alexander Auer & Franz Tödtling, 2014. "Driving factors and spatial scales for cluster development - The case of environmental technologies in Upper Austria," SRE-Disc sre-disc-2014_08, Institute for Multilevel Governance and Development, Department of Socioeconomics, Vienna University of Economics and Business.
    17. Roni Blushtein-Livnon & Tal Svoray & Itai Ficshhendler & Havatzelet Yahel & Emir Galilee & Michael Dorman, 2025. "Beyond Leaders and Laggards: A Typology of Renewable Energy Adoption Trajectories with Evidence from Off-Grid Communities," Papers 2505.22456, arXiv.org, revised Jul 2025.
    18. Mario Davide Parrilli, 2010. "Heterogeneous Social Capitals: A New Window of Opportunity for Local Economies," Working Papers 2010R06, Orkestra - Basque Institute of Competitiveness.
    19. Jukka Teras & Viktor Salenius & Laura Fagerlund & Lina Stanionyte, 2018. "Smart Specialisation in Sparsely Populated European Arctic Regions," JRC Research Reports JRC114273, Joint Research Centre.
    20. Flemming Sørensen & Jan Mattsson, 2016. "Speeding Up Innovation: Building Network Structures For Parallel Innovation," International Journal of Innovation Management (ijim), World Scientific Publishing Co. Pte. Ltd., vol. 20(02), pages 1-30, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:wly:mgtdec:v:47:y:2026:i:1:p:109-125. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Wiley Content Delivery (email available below). General contact details of provider: http://www3.interscience.wiley.com/cgi-bin/jhome/7976 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.