IDEAS home Printed from https://ideas.repec.org/a/kap/jtecht/v47y2022i6d10.1007_s10961-021-09890-1.html
   My bibliography  Save this article

Biopharmaceutical innovation ecosystems: a stakeholder model and the case of Lombardy

Author

Listed:
  • Alberto Bettanti

    (University of Genoa)

  • Antonella Lanati

    (Vita-Salute San Raffaele University)

  • Alessandro Missoni

    (University of Genoa)

Abstract

The purpose of this paper is to examine biopharma innovation ecosystems (IEs) through the lenses of a stakeholder model. In doing so, this work aims to answer the following research question: which stakeholders are required in an IE within biopharma industry and what are their main roles in the IE value creation. The research strategy was designed according to the grounded theory methodology. By applying this methodology, data were collected through verbatim interviews with several stakeholders. Both data collection and data analysis phases were carried out concurrently up to saturation where all data were identified and their consistency across the many forms was reached. The thesis of the paper intends to prove that biopharma IEs consist of a multilevel and longitudinal set of key stakeholders. Furthermore, by investigating the Lombardy case study, it explains the role of each stakeholder with regards to the comparative advantages required in the engagement with the IE. In addition, arising from a holistic view of the biopharma IEs, this research traces the biopharma IE dynamics through the analysis of the IE’s driving forces. This paper represents one of the first heuristic attempts to analyze in-depth biopharma IE from a holistic perspective. The paper findings can be considered to be an impactful extension to biopharma IEs world-wide. This broader scope is well supported by expert interviews as a central part of the methodology and by the investigated scientific literature.

Suggested Citation

  • Alberto Bettanti & Antonella Lanati & Alessandro Missoni, 2022. "Biopharmaceutical innovation ecosystems: a stakeholder model and the case of Lombardy," The Journal of Technology Transfer, Springer, vol. 47(6), pages 1948-1973, December.
    • Handle: RePEc:kap:jtecht:v:47:y:2022:i:6:d:10.1007_s10961-021-09890-1
    DOI: 10.1007/s10961-021-09890-1
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s10961-021-09890-1
    File Function: Abstract
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1007/s10961-021-09890-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Elias Carayannis & Evangelos Grigoroudis, 2016. "Quadruple Innovation Helix and Smart Specialization: Knowledge Production and National Competitiveness," Foresight-Russia Форсайт, CyberLeninka;Федеральное государственное автономное образовательное учреждение высшего образования «Национальный исследовательский университет «Высшая школа экономики», vol. 10(1 (eng)), pages 31-42.
    2. Erik Stam, 2015. "Entrepreneurial Ecosystems and Regional Policy: A Sympathetic Critique," European Planning Studies, Taylor & Francis Journals, vol. 23(9), pages 1759-1769, September.
    3. Zoltán J. Ács & Erkko Autio & László Szerb, 2015. "National Systems of Entrepreneurship: Measurement issues and policy implications," Chapters, in: Global Entrepreneurship, Institutions and Incentives, chapter 28, pages 523-541, Edward Elgar Publishing.
    4. Siddharth Vedula & Phillip H Kim, 2019. "Gimme shelter or fade away: the impact of regional entrepreneurial ecosystem quality on venture survival," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 28(4), pages 827-854.
    5. David B. Audretsch & Maksim Belitski, 2017. "Entrepreneurial ecosystems in cities: establishing the framework conditions," The Journal of Technology Transfer, Springer, vol. 42(5), pages 1030-1051, October.
    6. Michael Fritsch & Viktor Slavtchev, 2011. "Determinants of the Efficiency of Regional Innovation Systems," Regional Studies, Taylor & Francis Journals, vol. 45(7), pages 905-918.
    7. Sohvi Heaton & Donald S Siegel & David J Teece, 2019. "Universities and innovation ecosystems: a dynamic capabilities perspective," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 28(4), pages 921-939.
    8. David Audretsch, 2014. "From the entrepreneurial university to the university for the entrepreneurial society," The Journal of Technology Transfer, Springer, vol. 39(3), pages 313-321, June.
    9. Maryann Feldman & Donald S Siegel & Mike Wright, 2019. "New developments in innovation and entrepreneurial ecosystems," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 28(4), pages 817-826.
    10. Casper, Steven, 2007. "How do technology clusters emerge and become sustainable?: Social network formation and inter-firm mobility within the San Diego biotechnology cluster," Research Policy, Elsevier, vol. 36(4), pages 438-455, May.
    11. Philip E. Auerswald & Lokesh Dani, 2017. "The adaptive life cycle of entrepreneurial ecosystems: the biotechnology cluster," Small Business Economics, Springer, vol. 49(1), pages 97-117, June.
    12. Granstrand, Ove & Holgersson, Marcus, 2020. "Innovation ecosystems: A conceptual review and a new definition," Technovation, Elsevier, vol. 90.
    13. Cooke, Philip, 2002. "Regional Innovation Systems: General Findings and Some New Evidence from Biotechnology Clusters," The Journal of Technology Transfer, Springer, vol. 27(1), pages 133-145, January.
    14. Jessica D. Giusti & Stefania Ferrario & Federica Belfanti & Fernando G. Alberti, 2019. "The new triple-helix policy of Lombardy region: evidence from nine innovation clusters," Global Business and Economics Review, Inderscience Enterprises Ltd, vol. 21(3/4), pages 382-408.
    15. Christopher S. Hayter, 2016. "A trajectory of early-stage spinoff success: the role of knowledge intermediaries within an entrepreneurial university ecosystem," Small Business Economics, Springer, vol. 47(3), pages 633-656, October.
    16. Erik E. Lehmann & Matthias Menter, 2016. "University–industry collaboration and regional wealth," The Journal of Technology Transfer, Springer, vol. 41(6), pages 1284-1307, December.
    17. Zoltan J. Acs & Erik Stam & David B. Audretsch & Allan O’Connor, 2017. "The lineages of the entrepreneurial ecosystem approach," Small Business Economics, Springer, vol. 49(1), pages 1-10, June.
    18. Asheim, Bjorn T & Isaksen, Arne, 2002. "Regional Innovation Systems: The Integration of Local 'Sticky' and Global 'Ubiquitous' Knowledge," The Journal of Technology Transfer, Springer, vol. 27(1), pages 77-86, January.
    19. Catarina Maia & João Claro, 2013. "The role of a Proof of Concept Center in a university ecosystem: an exploratory study," The Journal of Technology Transfer, Springer, vol. 38(5), pages 641-650, October.
    20. Vlaisavljevic, Vesna & Medina, Carmen Cabello & Van Looy, Bart, 2020. "The role of policies and the contribution of cluster agency in the development of biotech open innovation ecosystem," Technological Forecasting and Social Change, Elsevier, vol. 155(C).
    21. Elias Carayannis & Ruslan Rakhmatullin, 2014. "The Quadruple/Quintuple Innovation Helixes and Smart Specialisation Strategies for Sustainable and Inclusive Growth in Europe and Beyond," Journal of the Knowledge Economy, Springer;Portland International Center for Management of Engineering and Technology (PICMET), vol. 5(2), pages 212-239, June.
    22. Kohler, Thomas, 2016. "Corporate accelerators: Building bridges between corporations and startups," Business Horizons, Elsevier, vol. 59(3), pages 347-357.
    23. Elias Carayannis & Evangelos Grigoroudis, 2016. "Quadruple Innovation Helix and Smart Specialization: Knowledge Production and National Competitiveness," Foresight and STI Governance (Foresight-Russia till No. 3/2015), National Research University Higher School of Economics, vol. 10(1), pages 31-42.
    24. David B. Audretsch & James A. Cunningham & Donald F. Kuratko & Erik E. Lehmann & Matthias Menter, 2019. "Entrepreneurial ecosystems: economic, technological, and societal impacts," The Journal of Technology Transfer, Springer, vol. 44(2), pages 313-325, April.
    25. Oh, Deog-Seong & Phillips, Fred & Park, Sehee & Lee, Eunghyun, 2016. "Innovation ecosystems: A critical examination," Technovation, Elsevier, vol. 54(C), pages 1-6.
    26. Philip Cooke & Loet Leydesdorff, 2006. "Regional Development in the Knowledge-Based Economy: The Construction of Advantage," The Journal of Technology Transfer, Springer, vol. 31(1), pages 5-15, January.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Eva Panetti & Adele Parmentola & Marco Ferretti & Elisabeth Beck Reynolds, 2020. "Exploring the relational dimension in a smart innovation ecosystem: a comprehensive framework to define the network structure and the network portfolio," The Journal of Technology Transfer, Springer, vol. 45(6), pages 1775-1796, December.
    2. Rocha, Augusto & Brown, Ross & Mawson, Suzanne, 2021. "Capturing conversations in entrepreneurial ecosystems," Research Policy, Elsevier, vol. 50(9).
    3. Shi, Xianwei & Shi, Yongjiang, 2022. "Unpacking the process of resource allocation within an entrepreneurial ecosystem," Research Policy, Elsevier, vol. 51(9).
    4. Rocha, Augusto & Brown, Ross & Mawson, Suzanne, 2022. "Reprint of: Capturing conversations in entrepreneurial ecosystems," Research Policy, Elsevier, vol. 51(9).
    5. Daniel Sunghwan Cho & Paul Ryan & Giulio Buciuni, 2022. "Evolutionary entrepreneurial ecosystems: a research pathway," Small Business Economics, Springer, vol. 58(4), pages 1865-1883, April.
    6. Shi, Xianwei & Liang, Xingkun & Luo, Yining, 2023. "Unpacking the intellectual structure of ecosystem research in innovation studies," Research Policy, Elsevier, vol. 52(6).
    7. Abootorabi, Hooman & Wiklund, Johan & Johnson, Alan R. & Miller, Cameron D., 2021. "A holistic approach to the evolution of an entrepreneurial ecosystem: An exploratory study of academic spin-offs," Journal of Business Venturing, Elsevier, vol. 36(5).
    8. Uwe Cantner & James A. Cunningham & Erik E. Lehmann & Matthias Menter, 2021. "Entrepreneurial ecosystems: a dynamic lifecycle model," Small Business Economics, Springer, vol. 57(1), pages 407-423, June.
    9. Kapturkiewicz, Agata, 2022. "Varieties of Entrepreneurial Ecosystems: A comparative study of Tokyo and Bangalore," Research Policy, Elsevier, vol. 51(9).
    10. Maksim Belitski & Ana-Maria Grigore & Anca Bratu, 2021. "Political entrepreneurship: entrepreneurship ecosystem perspective," International Entrepreneurship and Management Journal, Springer, vol. 17(4), pages 1973-2004, December.
    11. Bessagnet, Arnauld & Crespo, Joan & Vicente, Jérôme, 2021. "Unraveling the multi-scalar and evolutionary forces of entrepreneurial ecosystems: A historical event analysis applied to IoT Valley," Technovation, Elsevier, vol. 108(C).
    12. Audretsch, David B. & Lehmann, Erik E. & Menter, Matthias & Wirsching, Katharine, 2021. "Intrapreneurship and absorptive capacities: The dynamic effect of labor mobility," Technovation, Elsevier, vol. 99(C).
    13. Jianhong Zhang & Désirée Gorp & Henk Kievit, 2023. "Digital technology and national entrepreneurship: An ecosystem perspective," The Journal of Technology Transfer, Springer, vol. 48(3), pages 1077-1105, June.
    14. Bernd Wurth & Erik Stam & Ben Spigel, 2022. "Toward an Entrepreneurial Ecosystem Research Program," Entrepreneurship Theory and Practice, , vol. 46(3), pages 729-778, May.
    15. Hannigan, Timothy R. & Briggs, Anthony R. & Valadao, Rodrigo & Seidel, Marc-David L. & Jennings, P. Devereaux, 2022. "A new tool for policymakers: Mapping cultural possibilities in an emerging AI entrepreneurial ecosystem," Research Policy, Elsevier, vol. 51(9).
    16. Massimo G. Colombo & Giovanni Battista Dagnino & Erik E. Lehmann & MariPaz Salmador, 2019. "The governance of entrepreneurial ecosystems," Small Business Economics, Springer, vol. 52(2), pages 419-428, February.
    17. Pankov, Susanne & Schneckenberg, Dirk & Velamuri, Vivek K., 2021. "Advocating sustainability in entrepreneurial ecosystems: Micro-level practices of sharing ventures," Technological Forecasting and Social Change, Elsevier, vol. 166(C).
    18. Christina Theodoraki & Alexis Catanzaro, 2022. "Widening the borders of entrepreneurial ecosystem through the international lens," The Journal of Technology Transfer, Springer, vol. 47(2), pages 383-406, April.
    19. Prokop, Daniel, 2021. "University entrepreneurial ecosystems and spinoff companies: Configurations, developments and outcomes," Technovation, Elsevier, vol. 107(C).
    20. Belitski, Maksim & Aginskaja, Anna & Marozau, Radzivon, 2019. "Commercializing university research in transition economies: Technology transfer offices or direct industrial funding?," Research Policy, Elsevier, vol. 48(3), pages 601-615.

    More about this item

    Keywords

    Biopharma industry; Innovation ecosystem; Innovation process; Breakthrough innovation; Biodrugs development; Biopharma innovative cluster;
    All these keywords.

    JEL classification:

    • O3 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:kap:jtecht:v:47:y:2022:i:6:d:10.1007_s10961-021-09890-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.