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A causal proportional hazards estimator under homogeneous or heterogeneous selection in an IV setting

Author

Listed:
  • Ditte Nørbo Sørensen

    (University of Copenhagen)

  • Torben Martinussen

    (University of Copenhagen)

  • Eric Tchetgen Tchetgen

    (Wharton, University of Pennsylvania)

Abstract

In this paper we present a framework to do estimation in a structural Cox model when there may be unobserved confounding. The model is phrased in terms of a selection bias function and a baseline model that describes how covariates affect the survival time in a scenario without exposure. In this way model congeniality is ensured. The method uses an instrumental variable. Interestingly, the formulated model turns out to have similarities to the so-called Cox–Aalen survival model for the observed data. We exploit this to enhance estimation of the unknown parameters. This also allows us to derive large sample properties of the proposed estimator.

Suggested Citation

  • Ditte Nørbo Sørensen & Torben Martinussen & Eric Tchetgen Tchetgen, 2019. "A causal proportional hazards estimator under homogeneous or heterogeneous selection in an IV setting," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 25(4), pages 639-659, October.
  • Handle: RePEc:spr:lifeda:v:25:y:2019:i:4:d:10.1007_s10985-019-09476-y
    DOI: 10.1007/s10985-019-09476-y
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    References listed on IDEAS

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    1. James Robins & Andrea Rotnitzky, 2004. "Estimation of treatment effects in randomised trials with non-compliance and a dichotomous outcome using structural mean models," Biometrika, Biometrika Trust, vol. 91(4), pages 763-783, December.
    2. T. Loeys & E. Goetghebeur, 2003. "A Causal Proportional Hazards Estimator for the Effect of Treatment Actually Received in a Randomized Trial with All-or-Nothing Compliance," Biometrics, The International Biometric Society, vol. 59(1), pages 100-105, March.
    3. Imbens, Guido W & Angrist, Joshua D, 1994. "Identification and Estimation of Local Average Treatment Effects," Econometrica, Econometric Society, vol. 62(2), pages 467-475, March.
    4. Børge G Nordestgaard & Tom M Palmer & Marianne Benn & Jeppe Zacho & Anne Tybjærg-Hansen & George Davey Smith & Nicholas J Timpson, 2012. "The Effect of Elevated Body Mass Index on Ischemic Heart Disease Risk: Causal Estimates from a Mendelian Randomisation Approach," PLOS Medicine, Public Library of Science, vol. 9(5), pages 1-13, May.
    5. S. Vansteelandt & E. Goetghebeur, 2003. "Causal inference with generalized structural mean models," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 65(4), pages 817-835, November.
    6. Jack Cuzick & Peter Sasieni & Jonathan Myles & Jonathan Tyrer, 2007. "Estimating the effect of treatment in a proportional hazards model in the presence of non‐compliance and contamination," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 69(4), pages 565-588, September.
    7. Paul S. Clarke & Frank Windmeijer, 2012. "Instrumental Variable Estimators for Binary Outcomes," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 107(500), pages 1638-1652, December.
    8. Li Chen & D. Y. Lin & Donglin Zeng, 2010. "Attributable fraction functions for censored event times," Biometrika, Biometrika Trust, vol. 97(3), pages 713-726.
    9. Paul Clarke & Frank Windmeijer, 2009. "Identification of Causal Effects on Binary Outcomes Using Structural Mean Models," The Centre for Market and Public Organisation 09/217, The Centre for Market and Public Organisation, University of Bristol, UK.
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