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Association between ischemic stroke and seropositive rheumatoid arthritis in Korea: A nationwide longitudinal cohort study

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  • Dong Hyun Lee
  • Seung Hun Sheen
  • Dong-Geun Lee
  • Jae-Won Jang
  • Dong Chan Lee
  • Seung-Ho Shin
  • In-bo Han
  • Je Beom Hong
  • Hakyung Kim
  • Seil Sohn

Abstract

The purpose of this longitudinal follow-up study was to investigate the risk of ischemic stroke nationwide in patients with seropositive rheumatoid arthritis (RA) and controls who were matched in age and sex. Patient data were collected from the National Health Insurance Service (NHIS) Health Screening (HEALS) cohort. Using the International Classification of Diseases code M05 (seropositive RA), with a prescription of any disease-modifying anti-rheumatic drug (DMARD), RA was identified. A total of 2,765 patients and 13,825 control subjects were included in our study. The 12-year incidence of ischemic stroke in each group was calculated using the Kaplan–Meier method. The risk ratio of ischemic stroke was estimated using Cox proportional hazards regression. Sixty-four patients (2.31%) in the seropositive RA group and 512 (3.70%) in the control group experienced ischemic stroke (P

Suggested Citation

  • Dong Hyun Lee & Seung Hun Sheen & Dong-Geun Lee & Jae-Won Jang & Dong Chan Lee & Seung-Ho Shin & In-bo Han & Je Beom Hong & Hakyung Kim & Seil Sohn, 2021. "Association between ischemic stroke and seropositive rheumatoid arthritis in Korea: A nationwide longitudinal cohort study," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-11, May.
    • Handle: RePEc:plo:pone00:0251851
    DOI: 10.1371/journal.pone.0251851
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    2. Ho, Daniel & Imai, Kosuke & King, Gary & Stuart, Elizabeth A., 2011. "MatchIt: Nonparametric Preprocessing for Parametric Causal Inference," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 42(i08).
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