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No Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Experimentally Elicited Social Preferences

Author

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  • Coren L Apicella
  • David Cesarini
  • Magnus Johannesson
  • Christopher T Dawes
  • Paul Lichtenstein
  • Björn Wallace
  • Jonathan Beauchamp
  • Lars Westberg

Abstract

Background: Oxytocin (OXT) has been implicated in a suite of complex social behaviors including observed choices in economic laboratory experiments. However, actual studies of associations between oxytocin receptor (OXTR) gene variants and experimentally elicited social preferences are rare. Methodology/Principal Findings: We test hypotheses of associations between social preferences, as measured by behavior in two economic games, and 9 single nucleotide polymorphisms (SNPs) of the OXTR gene in a sample of Swedish twins (n = 684). Two standard economic games, the dictator game and the trust game, both involving real monetary consequences, were used to elicit such preferences. After correction for multiple hypothesis testing, we found no significant associations between any of the 9 single nucleotide polymorphisms (SNPs) and behavior in either of the games. Conclusion: We were unable to replicate the most significant association reported in previous research between the amount donated in a dictator game and an OXTR genetic variant.

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  • Coren L Apicella & David Cesarini & Magnus Johannesson & Christopher T Dawes & Paul Lichtenstein & Björn Wallace & Jonathan Beauchamp & Lars Westberg, 2010. "No Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Experimentally Elicited Social Preferences," PLOS ONE, Public Library of Science, vol. 5(6), pages 1-8, June.
    • Handle: RePEc:plo:pone00:0011153
    DOI: 10.1371/journal.pone.0011153
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    1. Matthijs J H M van der Loos & Cornelius A Rietveld & Niina Eklund & Philipp D Koellinger & Fernando Rivadeneira & Gonçalo R Abecasis & Georgina A Ankra-Badu & Sebastian E Baumeister & Daniel J Benjami, 2013. "The Molecular Genetic Architecture of Self-Employment," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-15, April.
    2. Anna Dreber & David Rand & Nils Wernerfelt & Justin Garcia & Miguel Vilar & J. Lum & Richard Zeckhauser, 2011. "Dopamine and risk choices in different domains: Findings among serious tournament bridge players," Journal of Risk and Uncertainty, Springer, vol. 43(1), pages 19-38, August.
    3. Wernerfelt, Nils Christian & Rand, David Gertler & Lum, J. Koji & Zeckhauser, Richard Jay & Dreber, Anna & Garcia, Justin, 2011. "The Dopamine Receptor D4 Gene (DRD4) and Self-Reported Risk Taking in the Economic Domain," Scholarly Articles 5347066, Harvard Kennedy School of Government.
    4. Matthijs Loos & Philipp Koellinger & Patrick Groenen & Cornelius Rietveld & Fernando Rivadeneira & Frank Rooij & André Uitterlinden & Albert Hofman & A. Thurik, 2011. "Candidate gene studies and the quest for the entrepreneurial gene," Small Business Economics, Springer, vol. 37(3), pages 269-275, October.
    5. Songfa Zhong & Mikhail Monakhov & Helen P Mok & Terry Tong & Poh San Lai & Soo Hong Chew & Richard P Ebstein, 2012. "U-Shaped Relation between Plasma Oxytocin Levels and Behavior in the Trust Game," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-9, December.
    6. Verbeke, W. & Bagozzi, R.P. & van den Berg, W.E. & Lemmens, A., 2013. "Polymorphisms of the OXTR Gene to explain why sales professionals love to help customers," Other publications TiSEM c1303435-9d7f-4cc9-9fe4-f, Tilburg University, School of Economics and Management.
    7. Vanessa Mertins & Andrea B. Schote & Jobst Meyer, 2013. "Variants of the Monoamine Oxidase A Gene (MAOA) Predict Free-riding Behavior in Women in a Strategic Public Goods Experiment," IAAEU Discussion Papers 201302, Institute of Labour Law and Industrial Relations in the European Union (IAAEU).
    8. Chew, Soo Hong & Ebstein, Richard P. & Zhong, Songfa, 2013. "Sex-hormone genes and gender difference in ultimatum game: Experimental evidence from China and Israel," Journal of Economic Behavior & Organization, Elsevier, vol. 90(C), pages 28-42.
    9. Jonathan P. Beauchamp & David Cesarini & Magnus Johannesson & Matthijs J. H. M. van der Loos & Philipp D. Koellinger & Patrick J. F. Groenen & James H. Fowler & J. Niels Rosenquist & A. Roy Thurik & N, 2011. "Molecular Genetics and Economics," Journal of Economic Perspectives, American Economic Association, vol. 25(4), pages 57-82, Fall.

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