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Amyotrophic Lateral Sclerosis Risk, Family Income, and Fish Consumption Estimates of Mercury and Omega-3 PUFAs in the United States

Author

Listed:
  • Hannah I. Hoffman

    (Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA)

  • Walter G. Bradley

    (Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33146, USA)

  • Celia Y. Chen

    (Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA)

  • Erik P. Pioro

    (ALS and Neuromuscular Disease Center, Cleveland Clinic, Cleveland, OH 44195, USA)

  • Elijah W. Stommel

    (Department of Neurology, Geisel School of Medicine, Lebanon, NH 03756, USA)

  • Angeline S. Andrew

    (Department of Neurology, Geisel School of Medicine, Lebanon, NH 03756, USA)

Abstract

Most amyotrophic lateral sclerosis (ALS) cases are considered sporadic, without a known genetic basis, and lifestyle factors are suspected to play an etiologic role. We previously observed increased risk of ALS associated with high nail mercury levels as an exposure biomarker and thus hypothesized that mercury exposure via fish consumption patterns increases ALS risk. Lifestyle surveys were obtained from ALS patients ( n = 165) and n = 330 age- and sex-matched controls without ALS enrolled in New Hampshire, Vermont, or Ohio, USA. We estimated their annual intake of mercury and omega-3 polyunsaturated fatty acid (PUFA) via self-reported seafood consumption habits, including species and frequency. In our multivariable model, family income showed a significant positive association with ALS risk ( p = 0.0003, adjusted for age, sex, family history, education, and race). Neither the estimated annual mercury nor omega-3 PUFA intakes via seafood were associated with ALS risk. ALS incidence is associated with socioeconomic status; however, consistent with a prior international study, this relationship is not linked to mercury intake estimated via fish or seafood consumption patterns.

Suggested Citation

  • Hannah I. Hoffman & Walter G. Bradley & Celia Y. Chen & Erik P. Pioro & Elijah W. Stommel & Angeline S. Andrew, 2021. "Amyotrophic Lateral Sclerosis Risk, Family Income, and Fish Consumption Estimates of Mercury and Omega-3 PUFAs in the United States," IJERPH, MDPI, vol. 18(9), pages 1-10, April.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:9:p:4528-:d:542676
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    References listed on IDEAS

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    1. Jane A. Parkin Kullmann & Roger Pamphlett, 2018. "A Comparison of Mercury Exposure from Seafood Consumption and Dental Amalgam Fillings in People with and without Amyotrophic Lateral Sclerosis (ALS): An International Online Case-Control Study," IJERPH, MDPI, vol. 15(12), pages 1-14, December.
    2. Ho, Daniel E. & Imai, Kosuke & King, Gary & Stuart, Elizabeth A., 2007. "Matching as Nonparametric Preprocessing for Reducing Model Dependence in Parametric Causal Inference," Political Analysis, Cambridge University Press, vol. 15(3), pages 199-236, July.
    3. Dana K. Sackett & W. Gregory Cope & James A. Rice & D. Derek Aday, 2013. "The Influence of Fish Length on Tissue Mercury Dynamics: Implications for Natural Resource Management and Human Health Risk," IJERPH, MDPI, vol. 10(2), pages 1-22, February.
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    1. Katya Peycheva & Veselina Panayotova & Rositsa Stancheva & Lubomir Makedonski & Albena Merdzhanova & Nicola Cicero & Vincenzo Parrino & Francesco Fazio, 2021. "Trace Elements and Omega-3 Fatty Acids of Wild and Farmed Mussels ( Mytilus galloprovincialis ) Consumed in Bulgaria: Human Health Risks," IJERPH, MDPI, vol. 18(19), pages 1-15, September.

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