IDEAS home Printed from https://ideas.repec.org/a/eee/socmed/v331y2023ics0277953623004458.html
   My bibliography  Save this article

Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain

Author

Listed:
  • Jackson, Pamela
  • Spector, Antoinette L.
  • Strath, Larissa J.
  • Antoine, Lisa H.
  • Li, Peng
  • Goodin, Burel R.
  • Hidalgo, Bertha A.
  • Kempf, Mirjam-Colette
  • Gonzalez, Cesar E.
  • Jones, Alana C.
  • Foster, Thomas C.
  • Peterson, Jessica A.
  • Quinn, Tammie
  • Huo, Zhiguang
  • Fillingim, Roger
  • Cruz-Almeida, Yenisel
  • Aroke, Edwin N.

Abstract

An estimated 250 million people worldwide suffer from knee osteoarthritis (KOA), with older adults having greater risk. Like other age-related diseases, residents of high-deprivation neighborhoods experience worse KOA pain outcomes compared to their more affluent neighbors. The purpose of this study was to examine the relationship between neighborhood deprivation and pain severity in KOA and the influence of epigenetic age acceleration (EpAA) on that relationship. The sample of 128 participants was mostly female (60.9%), approximately half non-Hispanic Black (49.2%), and had a mean age of 58 years. Spearman bivariate correlations revealed that pain severity positively correlated with EpAA (ρ = 0.47, p ≤ 0.001) and neighborhood deprivation (ρ = 0.25, p = 0.004). We found a positive significant relationship between neighborhood deprivation and EpAA (ρ = 0.47, p ≤ 0.001). Results indicate a mediating relationship between neighborhood deprivation (predictor), EpAA (mediator), and pain severity (outcome variable). There was a significant indirect effect of neighborhood deprivation on pain severity through EpAA, as the mediator accounted for a moderate portion of the total effect, PM = 0.44. Epigenetic age acceleration may act as a mechanism through which neighborhood deprivation leads to worse KOA pain outcomes and may play a role in the well-documented relationship between the neighborhood of residence and age-related diseases.

Suggested Citation

  • Jackson, Pamela & Spector, Antoinette L. & Strath, Larissa J. & Antoine, Lisa H. & Li, Peng & Goodin, Burel R. & Hidalgo, Bertha A. & Kempf, Mirjam-Colette & Gonzalez, Cesar E. & Jones, Alana C. & Fos, 2023. "Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain," Social Science & Medicine, Elsevier, vol. 331(C).
    • Handle: RePEc:eee:socmed:v:331:y:2023:i:c:s0277953623004458
    DOI: 10.1016/j.socscimed.2023.116088
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0277953623004458
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.socscimed.2023.116088?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Yan Zhang & Rory Wilson & Jonathan Heiss & Lutz P. Breitling & Kai-Uwe Saum & Ben Schöttker & Bernd Holleczek & Melanie Waldenberger & Annette Peters & Hermann Brenner, 2017. "DNA methylation signatures in peripheral blood strongly predict all-cause mortality," Nature Communications, Nature, vol. 8(1), pages 1-11, April.
    2. Sawyer, P.J. & Major, B. & Casad, B.J. & Townsend, S.S.M. & Mendes, W.B., 2012. "Discrimination and the stress response: Psychological and physiological consequences of anticipating prejudice in interethnic interactions," American Journal of Public Health, American Public Health Association, vol. 102(5), pages 1020-1026.
    3. Man-Kit Lei & Ronald L Simons & Steven R H Beach & Robert A Philibert & Philippa Clarke, 2019. "Neighborhood Disadvantage and Biological Aging: Using Marginal Structural Models to Assess the Link Between Neighborhood Census Variables and Epigenetic Aging," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 74(7), pages 50-59.
    4. Dylan Shane Connor & Michael Storper, 2020. "The changing geography of social mobility in the United States," Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, vol. 117(48), pages 30309-30317, December.
    5. Singh, G.K., 2003. "Area Deprivation and Widening Inequalities in US Mortality, 1969-1998," American Journal of Public Health, American Public Health Association, vol. 93(7), pages 1137-1143.
    6. Evans, Linnea & Engelman, Michal & Mikulas, Alex & Malecki, Kristen, 2021. "How are social determinants of health integrated into epigenetic research? A systematic review," Social Science & Medicine, Elsevier, vol. 273(C).
    7. Cheryl R Clark & Mark J Ommerborn & DeMarc A Hickson & Kya N Grooms & Mario Sims & Herman A Taylor & Michelle A Albert, 2013. "Neighborhood Disadvantage, Neighborhood Safety and Cardiometabolic Risk Factors in African Americans: Biosocial Associations in the Jackson Heart Study," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-10, May.
    8. Teresa N. Brockie & Morgan Heinzelmann & Jessica Gill, 2013. "A Framework to Examine the Role of Epigenetics in Health Disparities among Native Americans," Nursing Research and Practice, Hindawi, vol. 2013, pages 1-9, December.
    9. Simons, Ronald L. & Lei, Man-Kit & Klopack, Eric & Beach, Steven R.H. & Gibbons, Frederick X. & Philibert, Robert A., 2021. "The effects of social adversity, discrimination, and health risk behaviors on the accelerated aging of African Americans: Further support for the weathering hypothesis," Social Science & Medicine, Elsevier, vol. 282(C).
    10. Lei, Man-Kit & Berg, Mark T. & Simons, Ronald L. & Beach, Steven R.H., 2022. "Neighborhood structural disadvantage and biological aging in a sample of Black middle age and young adults," Social Science & Medicine, Elsevier, vol. 293(C).
    11. Simons, Ronald L. & Lei, Man Kit & Beach, Steven R.H. & Philibert, Robert A. & Cutrona, Carolyn E. & Gibbons, Frederick X. & Barr, Ashley, 2016. "Economic hardship and biological weathering: The epigenetics of aging in a U.S. sample of black women," Social Science & Medicine, Elsevier, vol. 150(C), pages 192-200.
    12. Xinshu Zhao & John G. Lynch & Qimei Chen, 2010. "Reconsidering Baron and Kenny: Myths and Truths about Mediation Analysis," Journal of Consumer Research, Journal of Consumer Research Inc., vol. 37(2), pages 197-206, August.
    13. Cohen, Deborah A. & Han, Bing & Derose, Kathryn Pitkin & Williamson, Stephanie & Marsh, Terry & Rudick, Jodi & McKenzie, Thomas L., 2012. "Neighborhood poverty, park use, and park-based physical activity in a Southern California city," Social Science & Medicine, Elsevier, vol. 75(12), pages 2317-2325.
    14. Ana Isabel Ribeiro & Joana Amaro & Cosima Lisi & Silvia Fraga, 2018. "Neighborhood Socioeconomic Deprivation and Allostatic Load: A Scoping Review," IJERPH, MDPI, vol. 15(6), pages 1-15, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lei, Man-Kit & Berg, Mark T. & Simons, Ronald L. & Beach, Steven R.H., 2022. "Neighborhood structural disadvantage and biological aging in a sample of Black middle age and young adults," Social Science & Medicine, Elsevier, vol. 293(C).
    2. Berg, Mark T. & Rogers, Ethan M. & Riley, Kendall & Lei, Man-Kit & Simons, Ronald L., 2022. "Incarceration exposure and epigenetic aging in neighborhood context," Social Science & Medicine, Elsevier, vol. 310(C).
    3. Liat Ayalon, 2018. "Perceived Age Discrimination: A Precipitator or a Consequence of Depressive Symptoms?," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 73(5), pages 860-869.
    4. FeCheng Ma & Farhan Khan & Kashif Ullah Khan & Si XiangYun, 2021. "Investigating the Impact of Information Technology, Absorptive Capacity, and Dynamic Capabilities on Firm Performance: An Empirical Study," SAGE Open, , vol. 11(4), pages 21582440211, November.
    5. Nosheena Yasir & Nasir Mahmood & Hafiz Shakir Mehmood & Osama Rashid & An Liren, 2021. "The Integrated Role of Personal Values and Theory of Planned Behavior to Form a Sustainable Entrepreneurial Intention," Sustainability, MDPI, vol. 13(16), pages 1-21, August.
    6. Mia M. Vainio & Daiva Daukantaitė, 2016. "Grit and Different Aspects of Well-Being: Direct and Indirect Relationships via Sense of Coherence and Authenticity," Journal of Happiness Studies, Springer, vol. 17(5), pages 2119-2147, October.
    7. Yu Ding & Wayne S. DeSarbo & Dominique M. Hanssens & Kamel Jedidi & John G. Lynch & Donald R. Lehmann, 2020. "The past, present, and future of measurement and methods in marketing analysis," Marketing Letters, Springer, vol. 31(2), pages 175-186, September.
    8. Lefroy, Kathryn & Tsarenko, Yelena, 2014. "Dependence and effectiveness in the nonprofit-corporate alliance: The mediating effect of objectives achievement," Journal of Business Research, Elsevier, vol. 67(9), pages 1959-1966.
    9. Thuy-Van Tran & Sinikka Lepistö & Janne Järvinen, 2021. "The relationship between subjectivity in managerial performance evaluation and the three dimensions of justice perception," Journal of Management Control: Zeitschrift für Planung und Unternehmenssteuerung, Springer, vol. 32(3), pages 369-399, September.
    10. Anxin Xu & Chenwen Wei & Manhua Zheng & Lili Sun & Decong Tang, 2022. "Influence of Perceived Value on Repurchase Intention of Green Agricultural Products: From the Perspective of Multi-Group Analysis," Sustainability, MDPI, vol. 14(22), pages 1-17, November.
    11. Xiangwei Li & Thomas Delerue & Ben Schöttker & Bernd Holleczek & Eva Grill & Annette Peters & Melanie Waldenberger & Barbara Thorand & Hermann Brenner, 2022. "Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    12. Alessia Acampora & Michele Preziosi & Maria Claudia Lucchetti & Roberto Merli, 2022. "The Role of Hotel Environmental Communication and Guests’ Environmental Concern in Determining Guests’ Behavioral Intentions," Sustainability, MDPI, vol. 14(18), pages 1-23, September.
    13. Arne K. Albrecht & Gianfranco Walsh & Simon Brach & Dwayne D. Gremler & Erica Herpen, 2017. "The influence of service employees and other customers on customer unfriendliness: a social norms perspective," Journal of the Academy of Marketing Science, Springer, vol. 45(6), pages 827-847, November.
    14. Yi He & Qimei Chen & Dana L. Alden, 2016. "Time will tell: managing post-purchase changes in brand attitude," Journal of the Academy of Marketing Science, Springer, vol. 44(6), pages 791-805, November.
    15. Abu Elnasr E. Sobaih & Ahmed Hasanein & Ibrahim Elshaer, 2020. "Influences of Green Human Resources Management on Environmental Performance in Small Lodging Enterprises: The Role of Green Innovation," Sustainability, MDPI, vol. 12(24), pages 1-19, December.
    16. Chen, Yuanyuan & Wang, Haining & Cheng, Zhiming & Smyth, Russell, 2023. "Education and Migrant Health in China," Economic Modelling, Elsevier, vol. 121(C).
    17. Hanen Khemakhem & Paulina Arroyo & Julio Montecinos, 2023. "Gender diversity on board committees and ESG disclosure: evidence from Canada," Journal of Management & Governance, Springer;Accademia Italiana di Economia Aziendale (AIDEA), vol. 27(4), pages 1397-1422, December.
    18. Connie Bateman & Sean Valentine & Terri Rittenburg, 2013. "Ethical Decision Making in a Peer-to-Peer File Sharing Situation: The Role of Moral Absolutes and Social Consensus," Journal of Business Ethics, Springer, vol. 115(2), pages 229-240, June.
    19. Juan Sandoval-Reyes & Sandra Idrovo-Carlier & Edison Jair Duque-Oliva, 2021. "Remote Work, Work Stress, and Work–Life during Pandemic Times: A Latin America Situation," IJERPH, MDPI, vol. 18(13), pages 1-12, July.
    20. Inés López López & Salvador Ruiz de Maya, 2012. "When hedonic products help regulate my mood," Marketing Letters, Springer, vol. 23(3), pages 701-717, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:socmed:v:331:y:2023:i:c:s0277953623004458. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/wps/find/journaldescription.cws_home/315/description#description .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.