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DNA methylation signatures in peripheral blood strongly predict all-cause mortality

Author

Listed:
  • Yan Zhang

    (German Research Cancer Research Center (DKFZ))

  • Rory Wilson

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Center for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Jonathan Heiss

    (German Research Cancer Research Center (DKFZ))

  • Lutz P. Breitling

    (German Research Cancer Research Center (DKFZ))

  • Kai-Uwe Saum

    (German Research Cancer Research Center (DKFZ))

  • Ben Schöttker

    (German Research Cancer Research Center (DKFZ)
    Network Ageing Research, University of Heidelberg)

  • Bernd Holleczek

    (Saarland Cancer Registry)

  • Melanie Waldenberger

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Center for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Annette Peters

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Center for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Hermann Brenner

    (German Research Cancer Research Center (DKFZ)
    German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT)
    German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ))

Abstract

DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we performed epigenome-wide screening and validation to identify mortality-related DNAm signatures in a general population-based cohort with up to 14 years follow-up. In the discovery panel in a case-cohort approach, 11,063 CpGs reach genome-wide significance (FDR

Suggested Citation

  • Yan Zhang & Rory Wilson & Jonathan Heiss & Lutz P. Breitling & Kai-Uwe Saum & Ben Schöttker & Bernd Holleczek & Melanie Waldenberger & Annette Peters & Hermann Brenner, 2017. "DNA methylation signatures in peripheral blood strongly predict all-cause mortality," Nature Communications, Nature, vol. 8(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14617
    DOI: 10.1038/ncomms14617
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    Cited by:

    1. Xiangwei Li & Thomas Delerue & Ben Schöttker & Bernd Holleczek & Eva Grill & Annette Peters & Melanie Waldenberger & Barbara Thorand & Hermann Brenner, 2022. "Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Matthias Wielscher & Pooja R. Mandaviya & Brigitte Kuehnel & Roby Joehanes & Rima Mustafa & Oliver Robinson & Yan Zhang & Barbara Bodinier & Esther Walton & Pashupati P. Mishra & Pascal Schlosser & Ro, 2022. "DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Jackson, Pamela & Spector, Antoinette L. & Strath, Larissa J. & Antoine, Lisa H. & Li, Peng & Goodin, Burel R. & Hidalgo, Bertha A. & Kempf, Mirjam-Colette & Gonzalez, Cesar E. & Jones, Alana C. & Fos, 2023. "Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain," Social Science & Medicine, Elsevier, vol. 331(C).
    4. Korous, Kevin M. & Surachman, Agus & Rogers, Charles R. & Cuevas, Adolfo G., 2023. "Parental education and epigenetic aging in middle-aged and older adults in the United States: A life course perspective," Social Science & Medicine, Elsevier, vol. 333(C).

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