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Mixed-Effects Models for Conditional Quantiles with Longitudinal Data

Author

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  • Liu Yuan

    (Medical University of South Carolina)

  • Bottai Matteo

    (University of South Carolina)

Abstract

We propose a regression method for the estimation of conditional quantiles of a continuous response variable given a set of covariates when the data are dependent. Along with fixed regression coefficients, we introduce random coefficients which we assume to follow a form of multivariate Laplace distribution. In a simulation study, the proposed quantile mixed-effects regression is shown to model the dependence among longitudinal data correctly and estimate the fixed effects efficiently. It performs similarly to the linear mixed model at the central location when the regression errors are symmetrically distributed, but provides more efficient estimates when the errors are over-dispersed. At the same time, it allows the estimation at different locations of conditional distribution, which conveys a comprehensive understanding of data. We illustrate an application to clinical data where the outcome variable of interest is bounded within a closed interval.

Suggested Citation

  • Liu Yuan & Bottai Matteo, 2009. "Mixed-Effects Models for Conditional Quantiles with Longitudinal Data," The International Journal of Biostatistics, De Gruyter, vol. 5(1), pages 1-24, November.
  • Handle: RePEc:bpj:ijbist:v:5:y:2009:i:1:n:28
    DOI: 10.2202/1557-4679.1186
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    References listed on IDEAS

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    2. Christian E. Galarza & Luis M. Castro & Francisco Louzada & Victor H. Lachos, 2020. "Quantile regression for nonlinear mixed effects models: a likelihood based perspective," Statistical Papers, Springer, vol. 61(3), pages 1281-1307, June.
    3. Georges Bresson & Guy Lacroix & Mohammad Arshad Rahman, 2021. "Bayesian panel quantile regression for binary outcomes with correlated random effects: an application on crime recidivism in Canada," Empirical Economics, Springer, vol. 60(1), pages 227-259, January.
    4. Yves S. Schüler, 2014. "Asymmetric Effects of Uncertainty over the Business Cycle: A Quantile Structural Vector Autoregressive Approach," Working Paper Series of the Department of Economics, University of Konstanz 2014-02, Department of Economics, University of Konstanz.
    5. Luca Merlo & Lea Petrella & Nikos Tzavidis, 2022. "Quantile mixed hidden Markov models for multivariate longitudinal data: An application to children's Strengths and Difficulties Questionnaire scores," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 71(2), pages 417-448, March.
    6. Elena Fabrizi & Alessio Farcomeni & Valerio Gatta, 2012. "Modelling work history patterns in the Italian labour market," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 21(2), pages 227-247, June.
    7. Chen, Xuerong & Tang, Niansheng & Zhou, Yong, 2016. "Quantile regression of longitudinal data with informative observation times," Journal of Multivariate Analysis, Elsevier, vol. 144(C), pages 176-188.
    8. Chenxi Li & N. Maritza Dowling & Rick Chappell, 2015. "Quantile regression with a change‐point model for longitudinal data: An application to the study of cognitive changes in preclinical alzheimer's disease," Biometrics, The International Biometric Society, vol. 71(3), pages 625-635, September.
    9. Machado, José A.F. & Santos Silva, J.M.C. & Wei, Kehai, 2016. "Quantiles, corners, and the extensive margin of trade," European Economic Review, Elsevier, vol. 89(C), pages 73-84.
    10. Xiaoming Lu & Zhaozhi Fan, 2020. "Generalized linear mixed quantile regression with panel data," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-16, August.
    11. Yuzhu Tian & Manlai Tang & Yanchao Zang & Maozai Tian, 2018. "Quantile regression for linear models with autoregressive errors using EM algorithm," Computational Statistics, Springer, vol. 33(4), pages 1605-1625, December.
    12. Xiaoming Lu & Zhaozhi Fan, 2015. "Weighted quantile regression for longitudinal data," Computational Statistics, Springer, vol. 30(2), pages 569-592, June.
    13. Mohammad Arshad Rahman & Angela Vossmeyer, 2019. "Estimation and Applications of Quantile Regression for Binary Longitudinal Data," Advances in Econometrics, in: Topics in Identification, Limited Dependent Variables, Partial Observability, Experimentation, and Flexible Modeling: Part B, volume 40, pages 157-191, Emerald Group Publishing Limited.
    14. Schüler, Yves S., 2020. "The impact of uncertainty and certainty shocks," Discussion Papers 14/2020, Deutsche Bundesbank.
    15. Maria Marino & Marco Alfó, 2015. "Latent drop-out based transitions in linear quantile hidden Markov models for longitudinal responses with attrition," Advances in Data Analysis and Classification, Springer;German Classification Society - Gesellschaft für Klassifikation (GfKl);Japanese Classification Society (JCS);Classification and Data Analysis Group of the Italian Statistical Society (CLADAG);International Federation of Classification Societies (IFCS), vol. 9(4), pages 483-502, December.
    16. Yuzhu Tian & Er’qian Li & Maozai Tian, 2016. "Bayesian joint quantile regression for mixed effects models with censoring and errors in covariates," Computational Statistics, Springer, vol. 31(3), pages 1031-1057, September.
    17. Fu, Liya & Wang, You-Gan, 2012. "Quantile regression for longitudinal data with a working correlation model," Computational Statistics & Data Analysis, Elsevier, vol. 56(8), pages 2526-2538.
    18. Maria Marino & Alessio Farcomeni, 2015. "Linear quantile regression models for longitudinal experiments: an overview," METRON, Springer;Sapienza Università di Roma, vol. 73(2), pages 229-247, August.
    19. Yuzhu Tian & Manlai Tang & Maozai Tian, 2018. "Joint modeling for mixed-effects quantile regression of longitudinal data with detection limits and covariates measured with error, with application to AIDS studies," Computational Statistics, Springer, vol. 33(4), pages 1563-1587, December.

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