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A Two-Phenotype Model of Immune Evasion by Cancer Cells

Author

Listed:
  • Bayer, Péter

    (Microeconomics & Public Economics, RS: GSBE ETBC)

  • Brown, Joel
  • Stankova, Katerina

    (DKE Scientific staff, RS: FSE DKE NSO)

Abstract

We propose a model with two types of cancer cells differentiated by their defense mechanisms against the immune system. ``Selfish'' cancer cells develop defense mechanisms that benefit the individual cell, whereas ``cooperative'' cells deploy countermeasures that increase the chance of survival of every cell. Our phenotypes capture the two main features of the tumor's efforts to avoid immune destruction, crypticity against immune cells for the selfish cells, and tumor-induced immunosuppression for the cooperative cells. We identify steady states of the system and show that only homogeneous tumors can be stable in both size and composition. We show that under generic parameter values, a tumor of selfish cells is more benign than a tumor of cooperative cells, and that a treatment against cancer crypticity may promote immunosuppression and increase cancer growth.

Suggested Citation

  • Bayer, Péter & Brown, Joel & Stankova, Katerina, 2017. "A Two-Phenotype Model of Immune Evasion by Cancer Cells," Research Memorandum 029, Maastricht University, Graduate School of Business and Economics (GSBE).
    • Handle: RePEc:unm:umagsb:2017029
    DOI: 10.26481/umagsb.2017029
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    References listed on IDEAS

    as
    1. Drew Fudenberg & Eric Maskin, 2008. "The Folk Theorem In Repeated Games With Discounting Or With Incomplete Information," World Scientific Book Chapters, in: Drew Fudenberg & David K Levine (ed.), A Long-Run Collaboration On Long-Run Games, chapter 11, pages 209-230, World Scientific Publishing Co. Pte. Ltd..
    2. Som B Ale & Joel S Brown & Amy T Sullivan, 2013. "Evolution of Cooperation: Combining Kin Selection and Reciprocal Altruism into Matrix Games with Social Dilemmas," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-8, May.
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