IDEAS home Printed from https://ideas.repec.org/p/rtv/ceisrp/370.html
   My bibliography  Save this paper

Early treatment in HCV: is it a cost-effective option from the Italian perspective?

Author

Listed:

Abstract

Background: The aim of this study is to perform an economic analysis to estimate the cost-utility of the early innovative therapy in Italy for managing HCV-infected patients. Methods: The incremental cost-utility analysis was carried out to quantify the benefits of the early treatment approach in HCV subjects. A Markov simulation model including direct and indirect costs and health outcomes was developed from Italian National Healthcare Service and societal perspective. 5,000 Monte Carlo simulations were performed on two distinct scenarios: Standard of Care (SoC) which includes 14.000 Genotype 1 patients in Italy treated with innovative interferon-free in the Fibrosis stage 3 and 4 (F3-F4) vs Early-treatment Scenario (ETS) where 2.000 patients were additionally treated with simeprevir plus peginterferon and ribavirin in the Fibrosis stage 2 (F2) (based on AIFA reimbursement criteria). A systematic literature review was carried out to identify epidemiological and economic data, which were subsequently used to inform the model. Furthermore, a one-way probabilistic sensitivity was performed in order to measure the relationship between the main parameters of the model and the cost-utility results. Results: The model shows that, in terms of Incremental Cost Effectiveness Ratio (ICER) per QALY gained, ETS appeared to be the most cost-effective option compared from both perspective Societal (ICER = €11.396) and NHS (ICER = €14.733) over a time horizon of 10 years. The cost-effectiveness of ETS is more sustainable as it extends the time horizon analysis (ICER = € 6.778 per QALY to 20 years and € 4,474 per QALY to 30 years). From the societal perspective the ETS represents the dominant option at a time horizon of 30 years. If we consider the sub-group population of treated patients (16.000 patients of which 2.000 not treated in the SoC), the ETS scenario was dominant after only 5 years horizon and cost-effective at 2 years of simulation. The one-way sensitivity analysis on the main variables confirmed the robustness of the model for the early-treatment approach. Conclusions: In conclusion, our model represents a tool for policy makers and health care professionals provide information on the cost-effectiveness of early-treatment approach in patients HCV-infected in Italy. Starting innovative treatment earlier regimens keeps HCV-infected patients in better health and reduces the incidence of HCV related events; this generating a gain both in terms of health of the patients and correct resource allocation.

Suggested Citation

  • Andrea Marcellusi & Raffaella Viti & Francesco Damele & Calogero Cammà & Gloria Taliani & Francesco Saverio Mennini, 2016. "Early treatment in HCV: is it a cost-effective option from the Italian perspective?," CEIS Research Paper 370, Tor Vergata University, CEIS, revised 23 Mar 2016.
    • Handle: RePEc:rtv:ceisrp:370
    as

    Download full text from publisher

    File URL: https://ceistorvergata.it/RePEc/rpaper/RP370.pdf
    File Function: Main text
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Francesco Saverio Mennini & Andrea Marcellusi & Massimo Andreoni & Antonio Gasbarrini & Salvatore Salomone & Antonio Craxì, 2014. "Health Policy Model: Long-term Predictive Results Associated With The Management Of HCV-Induced Diseases In Italy," CEIS Research Paper 308, Tor Vergata University, CEIS, revised 17 Feb 2014.
    2. AfDB AfDB, . "Annual Report 2012," Annual Report, African Development Bank, number 461.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Andrea Marcellusi & Raffaella Viti & Loreta A. Kondili & Stefano Rosato & Stefano Vella & Francesco Saverio Mennini, 2019. "Economic Consequences of Investing in Anti-HCV Antiviral Treatment from the Italian NHS Perspective: A Real-World-Based Analysis of PITER Data," PharmacoEconomics, Springer, vol. 37(2), pages 255-266, February.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. José Antonio Rodríguez Martín & Juan Dios Jiménez Aguilera & José Antonio Salinas Fernández & José María Martín Martín, 2016. "Millennium Development Goals 4 and 5: Progress in the Least Developed Countries of Asia," Social Indicators Research: An International and Interdisciplinary Journal for Quality-of-Life Measurement, Springer, vol. 129(2), pages 489-504, November.
    2. Craig Garthwaite & Tal Gross & Matthew J. Notowidigdo, 2014. "Public Health Insurance, Labor Supply, and Employment Lock," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 129(2), pages 653-696.
    3. Tarek Roshdy Gebba & Mohamed Gamal Aboelmaged, 2016. "Corporate Governance of UAE Financial Institutions: A Comparative Study between Conventional and Islamic Banks," Journal of Applied Finance & Banking, SCIENPRESS Ltd, vol. 6(5), pages 1-7.
    4. Nelson, Ewan & Warren, Peter, 2020. "UK transport decoupling: On track for clean growth in transport?," Transport Policy, Elsevier, vol. 90(C), pages 39-51.
    5. Antonio Bassanetti & Matteo Bugamelli & Sandro Momigliano & Roberto Sabbatini & Francesco Zollino, 2014. "The policy response to macroeconomic and fiscal imbalances in Italy in the last fifteen years," PSL Quarterly Review, Economia civile, vol. 67(268), pages 55-103.
    6. Joseph I. Uduji & Elda N. Okolo-Obasi & Simplice A. Asongu, 2019. "Responsible use of crop protection products and Nigeria's growth enhancement support scheme," Development in Practice, Taylor & Francis Journals, vol. 29(4), pages 448-463, May.
    7. Peter J. Rimmer, 2014. "Asian-Pacific Rim Logistics," Books, Edward Elgar Publishing, number 12949.
    8. Clarete, Ramon L. & Villamil, Isabela Rosario G., 2015. "Readiness of the Philippine Agriculture and Fisheries Sectors for the 2015 ASEAN Economic Community: A Rapid Appraisal," Research Paper Series DP 2015-43, Philippine Institute for Development Studies.
    9. Li, Xi & Yu, Biying, 2019. "Peaking CO2 emissions for China's urban passenger transport sector," Energy Policy, Elsevier, vol. 133(C).
    10. Emanuel, Elizabeth & Alleyne, Dillon & Phillips, Willard, 2013. "An assessment of fiscal and regulatory barriers to the deployment of energy efficiency and renewable energy technologies in Saint Lucia," Sede Subregional de la CEPAL para el Caribe (Estudios e Investigaciones) 38502, Naciones Unidas Comisión Económica para América Latina y el Caribe (CEPAL).
    11. Gang Chen, 2015. "From mercantile strategy to domestic demand stimulation: changes in China's solar PV subsidies," Asia Pacific Business Review, Taylor & Francis Journals, vol. 21(1), pages 96-112, January.
    12. Cristian Pana, 2013. "The National Central Bank’S Management Of Reserve Requirements," Working papers 16, Ecological University of Bucharest, Department of Economics.
    13. Junlakarn, Siripha & Kittner, Noah & Tongsopit, Sopitsuda & Saelim, Supawan, 2021. "A cross-country comparison of compensation mechanisms for distributed photovoltaics in the Philippines, Thailand, and Vietnam," Renewable and Sustainable Energy Reviews, Elsevier, vol. 145(C).
    14. McMahon, Rob, 2020. "Co-developing digital inclusion policy and programming with indigenous partners: Interventions from Canada," Internet Policy Review: Journal on Internet Regulation, Alexander von Humboldt Institute for Internet and Society (HIIG), Berlin, vol. 9(2), pages 1-26.
    15. Wang, Jianjun & Ortiz, Theresa & Navarro, Diana & Maier, Roland & Wang, Summer & Wang, Lisa & Wang, Libing, 2016. "An empirical study of early childhood support through partnership building," Evaluation and Program Planning, Elsevier, vol. 59(C), pages 74-80.
    16. Berta Morata & Chiara Cavalieri & Agatino Rizzo & Andrea Luciani, 2020. "Territories of Extraction: Mapping Palimpsests of Appropriation," Urban Planning, Cogitatio Press, vol. 5(2), pages 132-151.
    17. Adoracion M. NAVARRO & Gilberto M. LLANTO, . "Philippines Country Report," Chapters, in: Fauziah ZEN & Michael REGAN (ed.), Financing ASEAN Connectivity, chapter 7, pages 269-330, Economic Research Institute for ASEAN and East Asia (ERIA).
    18. John V. Duca, 2013. "Regionally, Housing Rebound Depends on Jobs, Local Supply Tightness," Annual Report, Federal Reserve Bank of Dallas.
    19. Fong Kean Yan & Yap Lya Keng & Kwek Kien Teng, 2016. "Empirical Analysis of House Price Bubble: A Case Study on Malaysia," International Journal of Business and Management, Canadian Center of Science and Education, vol. 11(12), pages 127-127, November.
    20. Divya Ravindranath, 2017. "Visa regulations and labour market restrictions: implications for Indian immigrant women in the United States," The Indian Journal of Labour Economics, Springer;The Indian Society of Labour Economics (ISLE), vol. 60(2), pages 217-232, June.

    More about this item

    Keywords

    cost-utility; early treatment; HCV management;
    All these keywords.

    JEL classification:

    • I19 - Health, Education, and Welfare - - Health - - - Other

    NEP fields

    This paper has been announced in the following NEP Reports:

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:rtv:ceisrp:370. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Barbara Piazzi (email available below). General contact details of provider: https://edirc.repec.org/data/csrotit.html .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.