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Persistence of innovation, technological change and quality-adjusted patents in the US Pharmaceutical industry

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  • Gautier Duflos

    (CES - Centre d'économie de la Sorbonne - UP1 - Université Paris 1 Panthéon-Sorbonne - CNRS - Centre National de la Recherche Scientifique, CREST-LEI - ENPC - École des Ponts ParisTech)

Abstract

This paper analyzes American pharmaceutical firms' persistence in innovating prior to the wave of mergers and acquisitions that accompanied the "Biotech revolution". We evaluate the impact of past innovative activity on firms' innovation propensities using a non-linear GMM estimator for exponential models that allows for predetermined regressors and linear feedback. We find that innovative activity at the firm level depends strongly on the technological importance of past innovations. In particular, breakthroughs depend largely on past innovations' scope, and this effect is likely to deter further pioneering behaviors rather than strengthen incentives to invest on non cumulative R&D. The results also shed light on the importance of small firms for the technological change in pharmaceuticals, and suggest that large firms may persist in using patents strategically to retain sales.

Suggested Citation

  • Gautier Duflos, 2006. "Persistence of innovation, technological change and quality-adjusted patents in the US Pharmaceutical industry," Université Paris1 Panthéon-Sorbonne (Post-Print and Working Papers) halshs-00113499, HAL.
    • Handle: RePEc:hal:cesptp:halshs-00113499
    Note: View the original document on HAL open archive server: https://shs.hal.science/halshs-00113499v2
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    References listed on IDEAS

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    1. Reinganum, Jennifer F, 1983. "Uncertain Innovation and the Persistence of Monopoly," American Economic Review, American Economic Association, vol. 73(4), pages 741-748, September.
    2. Wooldridge, Jeffrey M., 1997. "Multiplicative Panel Data Models Without the Strict Exogeneity Assumption," Econometric Theory, Cambridge University Press, vol. 13(5), pages 667-678, October.
    3. Sutton, John, 1996. "Technology and market structure," European Economic Review, Elsevier, vol. 40(3-5), pages 511-530, April.
    4. Mark Schankerman, 1998. "How Valuable is Patent Protection? Estimates by Technology Field," RAND Journal of Economics, The RAND Corporation, vol. 29(1), pages 77-107, Spring.
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    Cited by:

    1. Christian Le Bas & Nicolas Poussing, 2014. "Are Complex Innovators More Persistent Than Single Innovators? An Empirical Analysis Of Innovation Persistence Drivers," International Journal of Innovation Management (ijim), World Scientific Publishing Co. Pte. Ltd., vol. 18(01), pages 1-21.
    2. Choi, Joonhwan & Lee, Jaegul, 2017. "Repairing the R&D market failure: Public R&D subsidy and the composition of private R&D," Research Policy, Elsevier, vol. 46(8), pages 1465-1478.
    3. Christian Le Bas & Caroline Mothe & Thuc Uyen Nguyen-Thi, 2011. "Technological innovation persistence : Literature survey and exploration of the role of organizational innovation," Working Papers halshs-00649095, HAL.
    4. Christian Le Bas & Caroline Mothe & Thuc Uyen Nguyen-Thi, 2015. "The differentiated impacts of organizational innovation practices on technological innovation persistence," Post-Print hal-01301433, HAL.
    5. Christian Le Bas & Caroline Mothe & Thuc Uyen Nguyen-Thi, 2015. "The differentiated impacts of organizational innovation practices on technological innovation persistence," Post-Print halshs-01497289, HAL.

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