IDEAS home Printed from https://ideas.repec.org/p/dem/wpaper/wp-2023-049.html
   My bibliography  Save this paper

Genetic susceptibility to depression and the role of partnership status

Author

Listed:
  • Maria Gueltzow

    (Max Planck Institute for Demographic Research, Rostock, Germany)

  • Hannu Lahtinen
  • Maarten J. Bijlsma

    (Max Planck Institute for Demographic Research, Rostock, Germany)

  • Mikko Myrskylä

    (Max Planck Institute for Demographic Research, Rostock, Germany)

  • Pekka Martikainen

    (Max Planck Institute for Demographic Research, Rostock, Germany)

Abstract

This study explored the interplay between genetic predisposition, partnership status and depression by examining the association of a polygenic risk score (PGS) for depression with time to antidepressant purchasing and the moderating role of partnership status. We analysed data from 30,192 Finnish individuals with an accelerated failure time model. While the cumulative hazard of antidepressant purchasing varied across PGS and partnership status – with the highest cumulative hazard in the widowed group, followed by divorced, single, married and cohabiting – we found no evidence for an interaction between PGS and partnership status. Results were robust to different model specifications, gender stratification, choice of PGS, and endogenous selection. Although antidepressant purchasing correlated with both PGS and partnership status, we found no evidence that partnership status could partially offset or amplify the association between the PGS for depression and depression incidence.

Suggested Citation

  • Maria Gueltzow & Hannu Lahtinen & Maarten J. Bijlsma & Mikko Myrskylä & Pekka Martikainen, 2023. "Genetic susceptibility to depression and the role of partnership status," MPIDR Working Papers WP-2023-049, Max Planck Institute for Demographic Research, Rostock, Germany.
    • Handle: RePEc:dem:wpaper:wp-2023-049
    DOI: 10.4054/MPIDR-WP-2023-049
    as

    Download full text from publisher

    File URL: https://www.demogr.mpg.de/papers/working/wp-2023-049.pdf
    Download Restriction: no
    File URL: https://libkey.io/10.4054/MPIDR-WP-2023-049?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Andrew E. Clark & Ed Diener & Yannis Georgellis & Richard E. Lucas, 2008. "Lags And Leads in Life Satisfaction: a Test of the Baseline Hypothesis," Economic Journal, Royal Economic Society, vol. 118(529), pages 222-243, June.
    2. Julianne Holt-Lunstad & Timothy B Smith & J Bradley Layton, 2010. "Social Relationships and Mortality Risk: A Meta-analytic Review," PLOS Medicine, Public Library of Science, vol. 7(7), pages 1-1, July.
    3. Øystein Kravdal & Jonathan Wörn, 2023. "Mental and Physical Health Trajectories of Norwegian Parents and Children before and after Union Dissolution," Population and Development Review, The Population Council, Inc., vol. 49(1), pages 71-103, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Gueltzow, Maria & Lahtinen, Hannu & Bijlsma, Maarten J. & Myrskylä, Mikko & Martikainen, Pekka, 2024. "Genetic propensity to depression and the role of partnership status," Social Science & Medicine, Elsevier, vol. 351(C).
    2. Senik, Claudia, 2009. "Direct evidence on income comparisons and their welfare effects," Journal of Economic Behavior & Organization, Elsevier, vol. 72(1), pages 408-424, October.
    3. Maria Alzira Pimenta Dinis & Helder Fernando Pedrosa Sousa & Andreia de Moura & Lilian M. F. Viterbo & Ricardo J. Pinto, 2019. "Health Behaviors as a Mediator of the Association Between Interpersonal Relationships and Physical Health in a Workplace Context," IJERPH, MDPI, vol. 16(13), pages 1-9, July.
    4. Andrew E. Clark, 2018. "Four Decades of the Economics of Happiness: Where Next?," Review of Income and Wealth, International Association for Research in Income and Wealth, vol. 64(2), pages 245-269, June.
    5. Evans-Polce, Rebecca J. & Staff, Jeremy & Maggs, Jennifer L., 2016. "Alcohol abstention in early adulthood and premature mortality: Do early life factors, social support, and health explain this association?," Social Science & Medicine, Elsevier, vol. 163(C), pages 71-79.
    6. McDonald, Rebecca & Powdthavee, Nattavudh, 2018. "The Shadow Prices of Voluntary Caregiving: Using Panel Data of Well-Being to Estimate the Cost of Informal Care," IZA Discussion Papers 11545, Institute of Labor Economics (IZA).
    7. repec:hal:pseose:halshs-00566139 is not listed on IDEAS
    8. Paul Schumann & Lars Kuchinke, 2020. "Do(n’t) Worry, It’s Temporary: The Effects of Fixed-Term Employment on Affective Well-Being," Journal of Happiness Studies, Springer, vol. 21(7), pages 2557-2582, October.
    9. Rose, Damaris & Stavrova, Olga, 2019. "Does life satisfaction predict reemployment? Evidence form German panel data," Journal of Economic Psychology, Elsevier, vol. 72(C), pages 1-11.
    10. Nils Lerch, 2018. "The Causal Analysis of the Development of the Unemployment Effect on Life Satisfaction," SOEPpapers on Multidisciplinary Panel Data Research 991, DIW Berlin, The German Socio-Economic Panel (SOEP).
    11. AndrewE. Clark & Claudia Senik, 2010. "Who Compares to Whom? The Anatomy of Income Comparisons in Europe," Economic Journal, Royal Economic Society, vol. 120(544), pages 573-594, May.
    12. Santini, Ziggi Ivan & Jose, Paul E. & Koyanagi, Ai & Meilstrup, Charlotte & Nielsen, Line & Madsen, Katrine R. & Koushede, Vibeke, 2020. "Formal social participation protects physical health through enhanced mental health: A longitudinal mediation analysis using three consecutive waves of the Survey of Health, Ageing and Retirement in E," Social Science & Medicine, Elsevier, vol. 251(C).
    13. Ruta Clair & Maya Gordon & Matthew Kroon & Carolyn Reilly, 2021. "The effects of social isolation on well-being and life satisfaction during pandemic," Palgrave Communications, Palgrave Macmillan, vol. 8(1), pages 1-6, December.
    14. Winkelmann, Rainer, 2003. "Parental Separation and Well-Being of Youths," IZA Discussion Papers 894, Institute of Labor Economics (IZA).
    15. Lena Lämmle & Alexander Woll & Gert B. M. Mensink & Klaus Bös, 2013. "Distal and Proximal Factors of Health Behaviors and Their Associations with Health in Children and Adolescents," IJERPH, MDPI, vol. 10(7), pages 1-35, July.
    16. Silvia Loi & Peng Li & Mikko Myrskylä, 2022. "At the intersection of adverse life course pathways: the effects on health by nativity," MPIDR Working Papers WP-2022-018, Max Planck Institute for Demographic Research, Rostock, Germany.
    17. Fernando L Vázquez & Patricia Otero & J Antonio García-Casal & Vanessa Blanco & Ángela J Torres & Manuel Arrojo, 2018. "Efficacy of video game-based interventions for active aging. A systematic literature review and meta-analysis," PLOS ONE, Public Library of Science, vol. 13(12), pages 1-24, December.
    18. Andrew E. Clark, 2015. "SWB as a Measure of Individual Well-Being," Working Papers halshs-01134483, HAL.
    19. Van Landeghem, Bert & Vandeplas, Anneleen, 2018. "The relationship between status and happiness: Evidence from the caste system in rural India," Journal of Behavioral and Experimental Economics (formerly The Journal of Socio-Economics), Elsevier, vol. 77(C), pages 62-71.
    20. Anna Matysiak & Letizia Mencarini & Daniele Vignoli, 2016. "Work–Family Conflict Moderates the Relationship Between Childbearing and Subjective Well-Being," European Journal of Population, Springer;European Association for Population Studies, vol. 32(3), pages 355-379, August.
    21. Senik, Claudia, 2008. "Is man doomed to progress?," Journal of Economic Behavior & Organization, Elsevier, vol. 68(1), pages 140-152, October.

    More about this item

    Keywords

    ;
    ;
    ;
    ;

    JEL classification:

    • J1 - Labor and Demographic Economics - - Demographic Economics
    • Z0 - Other Special Topics - - General

    NEP fields

    This paper has been announced in the following NEP Reports:

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:dem:wpaper:wp-2023-049. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Peter Wilhelm (email available below). General contact details of provider: https://www.demogr.mpg.de/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.