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The Effect Of Diabetes Complications On Health‐Related Quality Of Life: The Importance Of Longitudinal Data To Address Patient Heterogeneity

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  • Maria Alva
  • Alastair Gray
  • Borislava Mihaylova
  • Philip Clarke

Abstract

We estimate the impact of six diabetes‐related complications (myocardial infarction, ischaemic heart disease, stroke, heart failure, amputation and visual acuity) on quality of life, using seven rounds of EQ‐5D questionnaires administered between 1997 and 2007 in the UK Prospective Diabetes Study. The use of cross‐sectional data to make such estimates is widespread in the literature, being less expensive and easier to collect than repeated‐measures data. However, analysis of this dataset suggests that cross‐sectional analysis could produce biased estimates of the effect of complications on QoL. Using fixed effects estimators, we show that variation in the quality of life between patients is strongly influenced by time‐invariant patient characteristics. Our results highlight the importance of studying quality‐of‐life changes over time to distinguish between time‐invariant determinants of QoL and the effect on QoL of specific events such as diabetes complications. © 2013 The Authors. Health Economics Published by John Wiley & Sons Ltd.

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  • Maria Alva & Alastair Gray & Borislava Mihaylova & Philip Clarke, 2014. "The Effect Of Diabetes Complications On Health‐Related Quality Of Life: The Importance Of Longitudinal Data To Address Patient Heterogeneity," Health Economics, John Wiley & Sons, Ltd., vol. 23(4), pages 487-500, April.
    • Handle: RePEc:wly:hlthec:v:23:y:2014:i:4:p:487-500
    DOI: 10.1002/hec.2930
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    References listed on IDEAS

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    3. Tessa Peasgood & Alan Brennan & Peter Mansell & Jackie Elliott & Hasan Basarir & Jen Kruger, 2016. "The Impact of Diabetes-Related Complications on Preference-Based Measures of Health-Related Quality of Life in Adults with Type I Diabetes," Medical Decision Making, , vol. 36(8), pages 1020-1033, November.
    4. Katharina Kähm & Michael Laxy & Udo Schneider & Rolf Holle, 2019. "Exploring Different Strategies of Assessing the Economic Impact of Multiple Diabetes-Associated Complications and Their Interactions: A Large Claims-Based Study in Germany," PharmacoEconomics, Springer, vol. 37(1), pages 63-74, January.
    5. Joan Gil & Antoni Sicras-Mainar & Eugenio Zucchelli, 2018. "Uncontrolled diabetes and health care utilisation: panel data evidence from Spain," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 19(6), pages 785-795, July.
    6. Muhammad Irfan & Michael P. Cameron & Gazi Hassan, 2023. "The Causal Impact of Solid Fuel Use on Mortality A Cross- Country Panel Analysis," International Journal of Energy Economics and Policy, Econjournals, vol. 13(1), pages 144-153, January.
    7. Zwar, Larissa & König, Hans-Helmut & Hajek, André, 2018. "The impact of different types of informal caregiving on cognitive functioning of older caregivers: Evidence from a longitudinal, population-based study in Germany," Social Science & Medicine, Elsevier, vol. 214(C), pages 12-19.
    8. Joan Gil & Antonio Sicras-Mainar & Eugenio Zucchelli, 2016. "The effects of non-adherence on health care utilisation: panel data evidence on uncontrolled diabetes," Working Papers 2016-06, FEDEA.
    9. John Yfantopoulos & Athanasios Chantzaras, 2020. "Health-related quality of life and health utilities in insulin-treated type 2 diabetes: the impact of related comorbidities/complications," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 21(5), pages 729-743, July.
    10. Inigo Bermejo & Paul Tappenden & Ji-Hee Youn, 2017. "Replicating Health Economic Models: Firm Foundations or a House of Cards?," PharmacoEconomics, Springer, vol. 35(11), pages 1113-1121, November.
    11. Mengjun Wu & John Brazier & Benjamin Kearns & Clare Relton & Christine Smith & Cindy Cooper, 2015. "Examining the impact of 11 long-standing health conditions on health-related quality of life using the EQ-5D in a general population sample," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 16(2), pages 141-151, March.
    12. Chirok Han & Goeun Lee, 2017. "Efficient Estimation of Linear Panel Data Models with Sample Selection and Fixed Effects," Discussion Paper Series 1707, Institute of Economic Research, Korea University.
    13. Johanna Katharina Hohls & Hans-Helmut König & Eleanor Quirke & André Hajek, 2021. "Anxiety, Depression and Quality of Life—A Systematic Review of Evidence from Longitudinal Observational Studies," IJERPH, MDPI, vol. 18(22), pages 1-26, November.
    14. Laura Bojke & Andrea Manca & Miqdad Asaria & Ronan Mahon & Shijie Ren & Stephen Palmer, 2017. "How to Appropriately Extrapolate Costs and Utilities in Cost-Effectiveness Analysis," PharmacoEconomics, Springer, vol. 35(8), pages 767-776, August.
    15. Yu shin Park & Soo Young Kim & Eun-Cheol Park & Sung-In Jang, 2022. "Screening for Diabetes Complications during the COVID-19 Outbreak in South Korea," IJERPH, MDPI, vol. 19(9), pages 1-12, April.
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    17. Paolo Nicola Barbieri & Hieu Nguyen, 2022. "Diabetes and Young Adults’ Labor Supply: Evidence from a Novel Instrumental Variable Strategy," Journal of Labor Research, Springer, vol. 43(1), pages 1-23, March.

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